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The map label for this gene is argH [H]

Identifier: 62390286

GI number: 62390286

Start: 1472944

End: 1474377

Strand: Direct

Name: argH [H]

Synonym: cg1588

Alternate gene names: 62390286

Gene position: 1472944-1474377 (Clockwise)

Preceding gene: 62390285

Following gene: 62390287

Centisome position: 44.87

GC content: 59.34

Gene sequence:

>1434_bases
ATGGAACAGCACGGAACCAATGAAGGTGCGCTGTGGGGCGGCCGCTTCTCCGGTGGACCCTCCGAGGCCATGTTCGCCTT
GAGTGTCTCCACTCATTTCGACTGGGTTTTGGCCCCTTATGATGTGTTGGCCTCCAAGGCACACGCCAAGGTTTTGCACC
AAGCAGATCTACTTTCTGATGAAGATCTAGCCACCATGCTGGCTGGGCTTGATCAGCTGGGCAAGGATGTCGCCGACGGA
ACCTTCGGTCCGCTGCCTTCTGATGAGGATGTGCACGGCGCGATGGAACGCGGTCTGATTGACCGCGTTGGTCCTGAGGT
GGGCGGCCGTCTGCGCGCTGGTCGTTCCCGCAACGACCAGGTGGCAACCCTGTTCCGCATGTGGGTCCGCGACGCAGTGC
GCGACATCGCGCTGGGAACAACCGAGCTTGTCGACGCCCTCAGCGCCCAAGCTAAGGCACATGCAGGCGCGATCATGCCA
GGCAAGACCCACTTCCAGGCAGCTCAGCCGGTCCTTCTGGCACACCAGCTGCTGGCACACGCACAGCCTTTGCTGCGCGA
TATTGATCGTATCCGTGACCTGGACAAGCGTCTTGCGGTGTCTCCTTACGGTTCCGGCGCACTTGCTGGTTCCTCTTTGA
AGCTCAACCCTGAAGCAATCGCTGAAGAACTCGGCTTTGATTCCGCAGCAGATAACTCCATTGATGCCACCAGCTCCCGC
GATTTCGCATCTGAAACCGCCTTCGTGCTGGCGCAGCTTGCAGTGGATATGTCCCGCTTGGCTGAAGAAATCATCGCATG
GTGCACCCCAGAATTTGGTTACATCACCTTGTCTGATTCCTGGTCCACAGGCAGCTCAATCATGCCGCAGAAGAAGAACC
CTGACGTGGCAGAGCTGACCCGTGGCAAGTCTGGTCGCTTGATCGGTAACCTCACCGGTCTGCTGGCTACCCTGAAGGCA
CAGCCTTTAGCGTACAACCGCGACCTGCAGGAAGATAAGGAACCAATCGTAGATTCCGTGGCGCAGCTCAACCTGCTGCT
CCCTGCAATGACTGGTTTGGTTTCCACCTTGACCTTCAACACCGAGCGCATGCGTGAACTTGCACCAGCAGGTTTCACCC
TTGCCACCGACTTGGCTGAGTGGATGGTGCGCCAGGGCGTTCCATTCCGTGAGGCACACGAAGCATCCGGCGCTTGCGTG
CGGATCGCGGAGTCCAGGGGAGTGGACCTTATCGATCTCACTGATGAAGAACTCAGTGGCGTTGATGCACGTCTGACCCC
AGAGGTACGGGAAGTGCTCACCATTGATGGTGCAGTGGCTTCCCGTGCAACGCGCGGTGGAACCGCGGGCGTGCGGGTTG
CGGAGCAACGCGCACGTGTCGATGCCGCAAGTACCGCTCACGCGGAGTGGGCACGTGCGGGGGTACGTCGATAA

Upstream 100 bases:

>100_bases
GATCGCTAACAAGCGCGATCGCGAAGCTGGCAACAACTAAGCCACCTTTTCAAGCATCCAGACTAGAACTTCAAGTATTT
AGAAAGTAGAAGAACACCAC

Downstream 100 bases:

>100_bases
GCATTAGTTTATGGCCTGTGCTGCTTTCCGATTGCGGGAGTTGCACAGGCCATTTATTATCAATTCATGAATGGTTCCCC
TGATTACTCAAGAAAATCTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQADLLSDEDLATMLAGLDQLGKDVADG
TFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRDIALGTTELVDALSAQAKAHAGAIMP
GKTHFQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELTRGKSGRLIGNLTGLLATLKA
QPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFNTERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVDLIDLTDEELSGVDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR

Sequences:

>Translated_477_residues
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQADLLSDEDLATMLAGLDQLGKDVADG
TFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRDIALGTTELVDALSAQAKAHAGAIMP
GKTHFQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELTRGKSGRLIGNLTGLLATLKA
QPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFNTERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVDLIDLTDEELSGVDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR
>Mature_477_residues
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQADLLSDEDLATMLAGLDQLGKDVADG
TFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRDIALGTTELVDALSAQAKAHAGAIMP
GKTHFQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELTRGKSGRLIGNLTGLLATLKA
QPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFNTERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVDLIDLTDEELSGVDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=42.3580786026201, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=42.3580786026201, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=39.9563318777293, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=39.7379912663755, Blast_Score=314, Evalue=1e-85,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=41.6107382550336, Blast_Score=317, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=42.4107142857143, Blast_Score=347, Evalue=3e-96,
Organism=Drosophila melanogaster, GI221473854, Length=446, Percent_Identity=41.0313901345291, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI78706858, Length=446, Percent_Identity=41.0313901345291, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51042; Mature: 51042

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQADLLSD
CCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHCCCC
EDLATMLAGLDQLGKDVADGTFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHH
VATLFRMWVRDAVRDIALGTTELVDALSAQAKAHAGAIMPGKTHFQAAQPVLLAHQLLAH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHH
AQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCC
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
RGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFN
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACVRIAESRGVDLIDLTDEELSG
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCEEEECCCHHHCC
VDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR
CCCCCCHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQADLLSD
CCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHCCCC
EDLATMLAGLDQLGKDVADGTFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHH
VATLFRMWVRDAVRDIALGTTELVDALSAQAKAHAGAIMPGKTHFQAAQPVLLAHQLLAH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHH
AQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCC
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
RGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFN
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACVRIAESRGVDLIDLTDEELSG
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCEEEECCCHHHCC
VDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR
CCCCCCHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA