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The map label for this gene is argG [H]

Identifier: 62390285

GI number: 62390285

Start: 1471678

End: 1472883

Strand: Direct

Name: argG [H]

Synonym: cg1586

Alternate gene names: 62390285

Gene position: 1471678-1472883 (Clockwise)

Preceding gene: 62390284

Following gene: 62390286

Centisome position: 44.83

GC content: 56.8

Gene sequence:

>1206_bases
ATGACTAACCGCATCGTTCTTGCATACTCCGGCGGTCTGGACACCACTGTGGCAATTCCATACCTGAAGAAGATGATTGA
TGGTGAAGTCATCGCAGTTTCCCTCGACCTGGGCCAGGGTGGAGAGAACATGGACAACGTTCGCCAGCGTGCATTGGATG
CCGGTGCAGCTGAGTCCATCGTTGTTGATGCAAAGGATGAGTTCGCTGAGGAGTACTGCCTGCCAACCATCAAGGCAAAC
GGCATGTACATGAAGCAGTACCCACTGGTTTCTGCAATCTCCCGCCCACTGATCGTCAAGCACCTCGTTGAGGCTGGCAA
GCAGTTCAACGGTACCCACGTTGCACACGGCTGCACTGGTAAGGGCAACGACCAGGTTCGTTTCGAGGTCGGCTTCATGG
ACACCGATCCAAACCTGGAGATCATTGCACCTGCTCGTGACTTCGCATGGACCCGCGACAAGGCTATCGCCTTCGCCGAG
GAGAACAACGTTCCAATCGAGCAGTCCGTGAAGTCCCCATTCTCCATCGACCAGAACGTCTGGGGCCGCGCTATTGAGAC
CGGTTACCTGGAAGATCTGTGGAATGCTCCAACCAAGGACATCTACGCATACACCGAGGATCCAGCTCTGGGTAACGCTC
CAGATGAGGTCATCATCTCCTTCGAGGGTGGCAAGCCAGTCTCCATCGATGGCCGTCCAGTCTCCGTACTGCAGGCTATT
GAAGAGCTGAACCGTCGTGCAGGCGCACAGGGCGTTGGCCGCCTTGACATGGTTGAGGACCGTCTCGTGGGCATCAAGTC
CCGCGAAATCTACGAAGCACCAGGCGCAATCGCACTGATTAAGGCTCACGAGGCTTTGGAAGATGTCACCATCGAGCGCG
AACTGGCTCGCTACAAGCGCGGCGTTGACGCACGTTGGGCTGAGGAAGTATACGACGGCCTGTGGTTCGGACCTCTGAAG
CGCTCCCTGGACGCGTTCATTGATTCCACCCAGGAGCACGTCACCGGCGATATCCGCATGGTTCTGCACGCAGGTTCCAT
CACCATCAATGGTCGTCGTTCCAGCCACTCCCTGTACGACTTCAACCTGGCTACCTACGACACCGGCGACACCTTCGACC
AGACCCTGGCTAAGGGCTTTGTCCAGCTGCACGGTCTGTCCTCCAAGATCGCTAACAAGCGCGATCGCGAAGCTGGCAAC
AACTAA

Upstream 100 bases:

>100_bases
TTTTCGAGGAATACCAACCCTTTCAACACAATAATTTTCTTTAAACATCCTTGCTGTCCACCACGGCTGGCAAGGAACTT
AAAATGAAGGAGCACACCTC

Downstream 100 bases:

>100_bases
GCCACCTTTTCAAGCATCCAGACTAGAACTTCAAGTATTTAGAAAGTAGAAGAACACCACATGGAACAGCACGGAACCAA
TGAAGGTGCGCTGTGGGGCG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENMDNVRQRALDAGAAESIVVDAKDEFAEEYCLPTIKAN
GMYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTGKGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAE
ENNVPIEQSVKSPFSIDQNVWGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAI
EELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKRGVDARWAEEVYDGLWFGPLK
RSLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYDFNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGN
N

Sequences:

>Translated_401_residues
MTNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENMDNVRQRALDAGAAESIVVDAKDEFAEEYCLPTIKAN
GMYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTGKGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAE
ENNVPIEQSVKSPFSIDQNVWGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAI
EELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKRGVDARWAEEVYDGLWFGPLK
RSLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYDFNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGN
N
>Mature_400_residues
TNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENMDNVRQRALDAGAAESIVVDAKDEFAEEYCLPTIKANG
MYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTGKGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAEE
NNVPIEQSVKSPFSIDQNVWGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAIE
ELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKRGVDARWAEEVYDGLWFGPLKR
SLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYDFNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGNN

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=396, Percent_Identity=36.1111111111111, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI16950633, Length=396, Percent_Identity=36.1111111111111, Blast_Score=238, Evalue=9e-63,
Organism=Escherichia coli, GI1789563, Length=398, Percent_Identity=29.3969849246231, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324514, Length=420, Percent_Identity=32.6190476190476, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21358151, Length=400, Percent_Identity=34.5, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44135; Mature: 44004

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENMDNVRQRALDAGAAESI
CCCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEE
VVDAKDEFAEEYCLPTIKANGMYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTG
EEECHHHHHHHHCCCEEECCCEEEECCCHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCC
KGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAEENNVPIEQSVKSPFSIDQNV
CCCCEEEEEEEEECCCCCEEEEECCHHCCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHH
WGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAI
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHH
EELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKR
HHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GVDARWAEEVYDGLWFGPLKRSLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYD
CCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCEEEEEEECEEEECCCCCCCCEEE
FNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGNN
EEEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TNRIVLAYSGGLDTTVAIPYLKKMIDGEVIAVSLDLGQGGENMDNVRQRALDAGAAESI
CCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEE
VVDAKDEFAEEYCLPTIKANGMYMKQYPLVSAISRPLIVKHLVEAGKQFNGTHVAHGCTG
EEECHHHHHHHHCCCEEECCCEEEECCCHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCC
KGNDQVRFEVGFMDTDPNLEIIAPARDFAWTRDKAIAFAEENNVPIEQSVKSPFSIDQNV
CCCCEEEEEEEEECCCCCEEEEECCHHCCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHH
WGRAIETGYLEDLWNAPTKDIYAYTEDPALGNAPDEVIISFEGGKPVSIDGRPVSVLQAI
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHH
EELNRRAGAQGVGRLDMVEDRLVGIKSREIYEAPGAIALIKAHEALEDVTIERELARYKR
HHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GVDARWAEEVYDGLWFGPLKRSLDAFIDSTQEHVTGDIRMVLHAGSITINGRRSSHSLYD
CCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCCEEEEEEECEEEECCCCCCCCEEE
FNLATYDTGDTFDQTLAKGFVQLHGLSSKIANKRDREAGNN
EEEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA