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The map label for this gene is uvrB [H]

Identifier: 62390254

GI number: 62390254

Start: 1435509

End: 1437671

Strand: Direct

Name: uvrB [H]

Synonym: cg1550

Alternate gene names: 62390254

Gene position: 1435509-1437671 (Clockwise)

Preceding gene: 62390253

Following gene: 62390255

Centisome position: 43.73

GC content: 53.81

Gene sequence:

>2163_bases
TTGCTTGCACGCTGTTTTGCTGCGGGCCGCAACGTGTCCACCCTGTGGCGTATCCTAGAATGCATGGCTTTTGCTGCTGA
ACATCCTGTCCTGTCCCACTCTGAGCACCGCCCGGTTGGTGAAATCGAGCGTAGCGATGACAAATTTGTTGTCGTTAGTG
AATTTGAGCCTGCGGGTGACCAGCCTGCGGCTATTAAAGAGCTCGATGAGCGCTTGGATCGCGGTGAGCGGGACGTCGTT
TTGATGGGTGCTACTGGTACGGGTAAGTCCGCGACTGCGGCGTGGTTGATCGAAAAGCAGCAGCGCCCCGCTTTGGTGAT
GGCGCCGAATAAGACGCTGGCTGCGCAGTTGGCTAATGAATTGCGGCAGCTGTTGCCCAATAACGCGGTGGAGTATTTCG
TGTCTTATTACGATTACTACCAGCCAGAAGCGTATATCGCGCAGACTGATACCTATATTGAAAAGGACTCCTCGATTAAT
GAGGATGTGGAGCGTCTGCGTCACTCGGCGACGTCGTCTTTGCTGAGTAGGCGAGACGTCGTGGTTGTTAGTTCGGTGTC
GTGTATTTATGGCTTGGGCACTCCACAGTCTTATCTTGACCGTTCCGTTGTGTTGAACGTGGGGGAGGAGATCGACCGCG
ATCGCTTTTTGCGCCTATTGGTAGATATTCAATACGAACGCAATGATGTGGGCTTTACTCGTGGTGCTTTCCGCGTGAAG
GGCGATACCGTGGACATCATCCCGGCCTATGAGGAATTGGCGGTGCGCATTGAGTTTTTCGGTGATGAAATTGATGCGTT
GTACTACATCCATCCCCTGACTGGTGACACCATCCGGCAGGTGAATGAGATCCGTATTTTCCCAGCTACGCACTATGTTG
CGGGACCTGAGCGGATGGAAAAGGCAGTCGCTGATATTAAGGCGGAGTTGGAAGTGCGCCTGGCTGATTTGGAGAACCGT
GGCAAGTTATTGGAAGCGCAGCGTCTTAGGATGCGTACTGAATATGACTTAGAAATGATCGAGCAGGTTGGTTTCTGTTC
GGGCATTGAGAACTATTCTCGCCACATTGATGGACGTGGGGAGGGAACCGCACCGGCCACGCTGATTGACTATTTCCCAG
AGGATTTCCTCACCATCATCGATGAGTCTCACGTGACAGTCCCGCAGATCGGCGGCATGTTTGAGGGCGATATGTCCCGT
AAACGTAACCTCGTAGAATTCGGTTTCCGCCTGCCATCCGCGATGGATAACCGCCCATTGACCTGGGAGGAGTTCGATGA
ACGCCGTGGCCAAACGGTGTTCATGTCTGCAACTCCAGGCAAGTTTGAGATCGCTGCTGCTGATGGTGAGTTTGTGGAGC
AGGTCATTCGCCCAACAGGTCTGGTGGATCCAAAGGTCACCGTCAAGCCAACGAAGGGGCAGATTGATGATCTGATCCAT
GAAATTCGCCAACGCACCGATAAAGATGAGCGCGTTTTGGTCACCACATTGACCAAGAAAATGGCTGAGGATCTTACTGA
TTACCTGCTGGAAAACGGCATCCGCGTGCGCTACCTGCACTCAGATATTGATACCTTGCAGCGTGTGGAATTGCTGCGTC
AGCTTCGCCTGGGCGAATACGATGTGTTGGTAGGTATTAACCTGCTGCGTGAGGGCCTTGACCTGCCAGAAGTCTCTCTG
GTTGCGATTCTCGACGCCGACAAGGAAGGCTTCCTGCGCTCCACCACCTCACTGATTCAGACCATTGGCCGCGCCGCCCG
AAATGTGTCCGGCGAGGTCATCATGTACGCCGACAAGATCACTGATTCGATGCAGTATGCCATCGAGGAAACCGATCGAC
GCCGTGAAAAGCAGGTCGCTTATAACAAGGAACACGGCATCGATCCGCAGCCGCTTCGAAAGAAAATCGCGGACATCCTC
GACCAGGTCTATGACAATTCCGCTGATGGAGCAGGACCTTCTGCCTCTGGCGATGCGGCAGTCGTGGCTAAACCTGACGT
GTCTAGCATGCCCGCCAAAGAAGTGCAAAAGCTTATCGACGACCTCAGCGCTCAGATGGCTGCGGCCGCGCGGGAGCTCA
AGTTCGAGCTGGCAGGGCGTCTGCGAGATGAGATCTTCGAGCTCAAGAAGGAACTGAGAGGTATCAAGGATGCCGGCATC
TAA

Upstream 100 bases:

>100_bases
GTTGCATCGAGTCCGCGGGTTTCGCACGCTTGATCTAAATTCTTGAGGGTTTTCCGGCCGTTGTTTGCGCTAAACGTAGG
GGTCAAGCGTCGAAAAGCGC

Downstream 100 bases:

>100_bases
GTCAGCTTGCTCACTTAAAGCTTCGAAATAAGCCCTTAAACTCTCATTCTTTTGTTAGACTTGTTCACTAATTACAGACA
TCCAGGGGCTTAGATTTTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MLARCFAAGRNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGDQPAAIKELDERLDRGERDVV
LMGATGTGKSATAAWLIEKQQRPALVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSIN
EDVERLRHSATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERMEKAVADIKAELEVRLADLENR
GKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRGEGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSR
KRNLVEFGFRLPSAMDNRPLTWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSL
VAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKITDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADIL
DQVYDNSADGAGPSASGDAAVVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI

Sequences:

>Translated_720_residues
MLARCFAAGRNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGDQPAAIKELDERLDRGERDVV
LMGATGTGKSATAAWLIEKQQRPALVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSIN
EDVERLRHSATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERMEKAVADIKAELEVRLADLENR
GKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRGEGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSR
KRNLVEFGFRLPSAMDNRPLTWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSL
VAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKITDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADIL
DQVYDNSADGAGPSASGDAAVVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI
>Mature_720_residues
MLARCFAAGRNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGDQPAAIKELDERLDRGERDVV
LMGATGTGKSATAAWLIEKQQRPALVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSIN
EDVERLRHSATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERMEKAVADIKAELEVRLADLENR
GKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRGEGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSR
KRNLVEFGFRLPSAMDNRPLTWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSL
VAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKITDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADIL
DQVYDNSADGAGPSASGDAAVVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=56.2874251497006, Blast_Score=736, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=212, Percent_Identity=23.5849056603774, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 81050; Mature: 81050

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLARCFAAGRNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGD
CCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
QPAAIKELDERLDRGERDVVLMGATGTGKSATAAWLIEKQQRPALVMAPNKTLAAQLANE
CCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHH
LRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSSLLSRRDV
HHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
VVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
EEEECCHHHEECCCCHHHHCHHHHHHCHHHCCHHHHHHHHHHHEECCCCCCCCCCEEEEC
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERME
CCEEEEEECHHHHEEEEEEECCCCCEEEEEECCCCHHHHHHHHEEEEECCCCCCCHHHHH
KAVADIKAELEVRLADLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRG
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCC
EGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSAMDNRPL
CCCCCHHHHHHCCHHHHHHHCCCCCCHHCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCCC
TWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
CHHHHHHHCCCEEEEECCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEY
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCC
DVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKI
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
TDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADILDQVYDNSADGAGPSASGDAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
VVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLARCFAAGRNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGD
CCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
QPAAIKELDERLDRGERDVVLMGATGTGKSATAAWLIEKQQRPALVMAPNKTLAAQLANE
CCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHH
LRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSSLLSRRDV
HHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
VVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
EEEECCHHHEECCCCHHHHCHHHHHHCHHHCCHHHHHHHHHHHEECCCCCCCCCCEEEEC
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERME
CCEEEEEECHHHHEEEEEEECCCCCEEEEEECCCCHHHHHHHHEEEEECCCCCCCHHHHH
KAVADIKAELEVRLADLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRG
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCC
EGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSAMDNRPL
CCCCCHHHHHHCCHHHHHHHCCCCCCHHCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCCC
TWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
CHHHHHHHCCCEEEEECCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEY
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCC
DVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKI
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
TDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADILDQVYDNSADGAGPSASGDAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
VVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]