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The map label for this gene is coaE

Identifier: 62390244

GI number: 62390244

Start: 1426746

End: 1427348

Strand: Direct

Name: coaE

Synonym: cg1538

Alternate gene names: 62390244

Gene position: 1426746-1427348 (Clockwise)

Preceding gene: 62390243

Following gene: 62390245

Centisome position: 43.46

GC content: 52.4

Gene sequence:

>603_bases
ATGTTGCGCATTGGACTAACAGGAGGGATCGGCAGCGGTAAATCTACCGTTGCCGATCTTTTGTCATCTGAAGGATTTCT
CATCGTCGACGCGGACCAAGTTGCCCGCGATATCGTCGAACCCGGACAACCGGCATTAGCAGAGCTAGCTGAAGCTTTTG
GCCAAGACATCTTAAAACCCGACGGCACTCTAGACCGCGCGGGATTAGCAGCCAAAGCATTTGTCAGCGAAGAACAAACA
GCGCTGCTCAATGCCATTACCCACCCTCGTATCGCCGAAGAGTCAGCTCGTCGATTCAACGAAGCCGAAGATCAAGGCGC
CAAAGTTGCGGTTTATGACATGCCTTTGCTTGTAGAAAAAGGCCTTGACCGCAAGATGGACCTTGTCGTCGTAGTTGATG
TTGACGTAGAGGAACGCGTCCGCAGACTTGTGGAAAAACGTGGCCTCACAGAGGACGACGTGCGGCGTCGAATCGCTTCT
CAAGTGCCCGACGACGTCAGACTTAAAGCCGCTGACATCGTTGTGGACAATAACGGCACGCTAGAGGACCTTCATGCTGA
AGCAAGCAAGCTGATTGCTGAGATTCTTAGTCGCGTGAATTAG

Upstream 100 bases:

>100_bases
GCCGCGAAATTCGGTGAAATTGAAGGTATTCCTGCAGATCAGGCAAATTCTTCCACGACTGTGATCAAGGTCAACGGCAA
GAACGAGTAACCTGGGATCC

Downstream 100 bases:

>100_bases
CACTAAAACATCGTCAAAGTCGATCTACCAAGAAAGCCCTCGGAACAATGCAATTACATCAGTTCCGAGGGCTTTTTCGT
TTGAGTGCTGGTGATGAACG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MLRIGLTGGIGSGKSTVADLLSSEGFLIVDADQVARDIVEPGQPALAELAEAFGQDILKPDGTLDRAGLAAKAFVSEEQT
ALLNAITHPRIAEESARRFNEAEDQGAKVAVYDMPLLVEKGLDRKMDLVVVVDVDVEERVRRLVEKRGLTEDDVRRRIAS
QVPDDVRLKAADIVVDNNGTLEDLHAEASKLIAEILSRVN

Sequences:

>Translated_200_residues
MLRIGLTGGIGSGKSTVADLLSSEGFLIVDADQVARDIVEPGQPALAELAEAFGQDILKPDGTLDRAGLAAKAFVSEEQT
ALLNAITHPRIAEESARRFNEAEDQGAKVAVYDMPLLVEKGLDRKMDLVVVVDVDVEERVRRLVEKRGLTEDDVRRRIAS
QVPDDVRLKAADIVVDNNGTLEDLHAEASKLIAEILSRVN
>Mature_200_residues
MLRIGLTGGIGSGKSTVADLLSSEGFLIVDADQVARDIVEPGQPALAELAEAFGQDILKPDGTLDRAGLAAKAFVSEEQT
ALLNAITHPRIAEESARRFNEAEDQGAKVAVYDMPLLVEKGLDRKMDLVVVVDVDVEERVRRLVEKRGLTEDDVRRRIAS
QVPDDVRLKAADIVVDNNGTLEDLHAEASKLIAEILSRVN

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=180, Percent_Identity=36.6666666666667, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI191252795, Length=180, Percent_Identity=36.6666666666667, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI110227607, Length=182, Percent_Identity=34.0659340659341, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI110227605, Length=182, Percent_Identity=34.0659340659341, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI110227603, Length=182, Percent_Identity=34.0659340659341, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI110227601, Length=182, Percent_Identity=34.0659340659341, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI205277394, Length=182, Percent_Identity=34.0659340659341, Blast_Score=101, Evalue=4e-22,
Organism=Escherichia coli, GI1786292, Length=193, Percent_Identity=38.860103626943, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17554944, Length=197, Percent_Identity=37.0558375634518, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25143409, Length=197, Percent_Identity=29.4416243654822, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=37, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24644728, Length=194, Percent_Identity=36.5979381443299, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24658602, Length=189, Percent_Identity=32.8042328042328, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE1_CORGL (P58897)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600577.1
- RefSeq:   YP_225646.1
- ProteinModelPortal:   P58897
- SMR:   P58897
- GeneID:   1019336
- GeneID:   3344150
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1538
- KEGG:   cgl:NCgl1306
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   P58897
- ProtClustDB:   PRK14734
- BioCyc:   CGLU196627:CG1538-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21663; Mature: 21663

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIGLTGGIGSGKSTVADLLSSEGFLIVDADQVARDIVEPGQPALAELAEAFGQDILKP
CEEEEECCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
DGTLDRAGLAAKAFVSEEQTALLNAITHPRIAEESARRFNEAEDQGAKVAVYDMPLLVEK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHC
GLDRKMDLVVVVDVDVEERVRRLVEKRGLTEDDVRRRIASQVPDDVRLKAADIVVDNNGT
CCCCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
LEDLHAEASKLIAEILSRVN
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRIGLTGGIGSGKSTVADLLSSEGFLIVDADQVARDIVEPGQPALAELAEAFGQDILKP
CEEEEECCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
DGTLDRAGLAAKAFVSEEQTALLNAITHPRIAEESARRFNEAEDQGAKVAVYDMPLLVEK
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHC
GLDRKMDLVVVVDVDVEERVRRLVEKRGLTEDDVRRRIASQVPDDVRLKAADIVVDNNGT
CCCCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
LEDLHAEASKLIAEILSRVN
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626