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The map label for this gene is ptsG

Identifier: 62390243

GI number: 62390243

Start: 1424684

End: 1426735

Strand: Direct

Name: ptsG

Synonym: cg1537

Alternate gene names: 62390243

Gene position: 1424684-1426735 (Clockwise)

Preceding gene: 62390242

Following gene: 62390244

Centisome position: 43.4

GC content: 52.19

Gene sequence:

>2052_bases
ATGGCGTCCAAACTGACGACGACATCGCAACATATTCTGGAAAACCTTGGTGGACCAGACAATATTACTTCGATGACTCA
CTGTGCGACTCGCCTTCGCTTCCAAGTGAAGGATCAATCCATTGTTGATCAACAAGAAATTGACTCCGACCCATCAGTTC
TTGGCGTAGTACCCCAAGGATCCACCGGTATGCAGGTGGTGATGGGTGGATCTGTTGCAAACTATTACCAAGAAATCCTC
AAACTTGATGGAATGAAGCACTTCGCCGACGGTGAAGCTACAGAGAGTTCATCCAAGAAGGAATACGGCGGAGTCCGTGG
CAAGTACTCGTGGATTGACTACGCCTTCGAGTTCTTGTCTGATACTTTCCGACCAATCCTGTGGGCCCTGCTTGGTGCCT
CACTGATTATTACCTTGTTGGTTCTTGCGGATACTTTCGGTTTGCAAGACTTCCGCGCTCCAATGGATGAGCAGCCTGAT
ACTTATGTATTCCTGCACTCCATGTGGCGCTCGGTCTTCTACTTCCTGCCAATTATGGTTGGTGCCACCGCAGCTCGAAA
GCTCGGCGCAAACGAGTGGATTGGTGCAGCTATTCCAGCCGCACTTCTTACTCCAGAATTCTTGGCACTGGGTTCTGCCG
GCGATACCGTCACAGTCTTTGGCCTGCCAATGGTTCTGAATGACTACTCCGGACAGGTATTCCCACCGCTGATTGCAGCA
ATTGGTCTGTACTGGGTGGAAAAGGGACTGAAGAAGATCATCCCTGAAGCAGTCCAAATGGTGTTCGTCCCATTCTTCTC
CCTGCTGATTATGATCCCAGCGACCGCATTCCTGCTTGGACCTTTCGGCATCGGTGTTGGTAACGGAATTTCCAACCTGC
TTGAAGCGATTAACAACTTCAGCCCATTTATTCTTTCCATCGTTATCCCATTGCTCTACCCATTCTTGGTTCCACTTGGA
TTGCACTGGCCACTAAACGCCATCATGATCCAGAACATCAACACCCTGGGTTACGACTTCATTCAGGGACCAATGGGTGC
CTGGAACTTCGCCTGCTTCGGCCTGGTCACCGGCGTGTTCTTGCTCTCCATTAAGGAACGAAACAAGGCCATGCGTCAGG
TTTCCCTGGGTGGCATGTTGGCTGGTTTGCTCGGCGGCATTTCCGAGCCTTCCCTCTACGGTGTTCTGCTCCGATTCAAG
AAGACCTACTTCCGCCTCCTGCCGGGTTGTTTGGCAGGCGGTATCGTGATGGGCATCTTCGACATCAAGGCGTACGCTTT
CGTGTTCACCTCCTTGCTTACCATCCCAGCAATGGACCCATGGTTGGGCTACACCATTGGTATCGCAGTTGCATTCTTCG
TTTCCATGTTCCTTGTTCTCGCACTGGACTACCGTTCCAACGAAGAGCGCGATGAGGCACGTGCAAAGGTTGCTGCTGAC
AAGCAGGCAGAAGAAGATCTGAAGGCAGAAGCTAATGCAACTCCTGCAGCTCCAGTAGCTGCTGCAGGTGCGGGAGCCGG
TGCAGGTGCAGGAGCCGCTGCTGGCGCTGCAACCGCCGTGGCAGCTAAGCCGAAGCTGGCCGCTGGGGAAGTAGTGGACA
TTGTTTCCCCACTCGAAGGCAAGGCAATTCCACTTTCTGAAGTACCTGACCCAATCTTTGCAGCAGGCAAGCTTGGACCA
GGCATTGCAATCCAACCAACTGGAAACACCGTTGTTGCTCCAGCAGACGCTACTGTCATCCTTGTCCAGAAATCTGGACA
CGCAGTGGCATTGCGCTTAGATAGCGGAGTTGAAATCCTTGTCCACGTTGGATTGGACACCGTGCAATTGGGCGGCGAAG
GCTTCACCGTTCACGTTGAGCGCAGGCAGCAAGTCAAGGCGGGGGATCCACTGATCACTTTTGACGCTGACTTCATTCGA
TCCAAGGATCTACCTTTGATCACCCCAGTTGTGGTGTCTAACGCCGCGAAATTCGGTGAAATTGAAGGTATTCCTGCAGA
TCAGGCAAATTCTTCCACGACTGTGATCAAGGTCAACGGCAAGAACGAGTAA

Upstream 100 bases:

>100_bases
CCGATTCTTTTTCGGCCCAATTCGTAACGGCGATCCTCTTAAGTGGACAAGAAAGTCTCTTGCCCGCGGGAGACAGACCC
TACGTTTAGAAAGGTTTGAC

Downstream 100 bases:

>100_bases
CCTGGGATCCATGTTGCGCATTGGACTAACAGGAGGGATCGGCAGCGGTAAATCTACCGTTGCCGATCTTTTGTCATCTG
AAGGATTTCTCATCGTCGAC

Product: glucose-specific enzyme II BC component of PTS

Products: NA

Alternate protein names: EII-Man/EIII-Man; EIIBCA-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MASKLTTTSQHILENLGGPDNITSMTHCATRLRFQVKDQSIVDQQEIDSDPSVLGVVPQGSTGMQVVMGGSVANYYQEIL
KLDGMKHFADGEATESSSKKEYGGVRGKYSWIDYAFEFLSDTFRPILWALLGASLIITLLVLADTFGLQDFRAPMDEQPD
TYVFLHSMWRSVFYFLPIMVGATAARKLGANEWIGAAIPAALLTPEFLALGSAGDTVTVFGLPMVLNDYSGQVFPPLIAA
IGLYWVEKGLKKIIPEAVQMVFVPFFSLLIMIPATAFLLGPFGIGVGNGISNLLEAINNFSPFILSIVIPLLYPFLVPLG
LHWPLNAIMIQNINTLGYDFIQGPMGAWNFACFGLVTGVFLLSIKERNKAMRQVSLGGMLAGLLGGISEPSLYGVLLRFK
KTYFRLLPGCLAGGIVMGIFDIKAYAFVFTSLLTIPAMDPWLGYTIGIAVAFFVSMFLVLALDYRSNEERDEARAKVAAD
KQAEEDLKAEANATPAAPVAAAGAGAGAGAGAAAGAATAVAAKPKLAAGEVVDIVSPLEGKAIPLSEVPDPIFAAGKLGP
GIAIQPTGNTVVAPADATVILVQKSGHAVALRLDSGVEILVHVGLDTVQLGGEGFTVHVERRQQVKAGDPLITFDADFIR
SKDLPLITPVVVSNAAKFGEIEGIPADQANSSTTVIKVNGKNE

Sequences:

>Translated_683_residues
MASKLTTTSQHILENLGGPDNITSMTHCATRLRFQVKDQSIVDQQEIDSDPSVLGVVPQGSTGMQVVMGGSVANYYQEIL
KLDGMKHFADGEATESSSKKEYGGVRGKYSWIDYAFEFLSDTFRPILWALLGASLIITLLVLADTFGLQDFRAPMDEQPD
TYVFLHSMWRSVFYFLPIMVGATAARKLGANEWIGAAIPAALLTPEFLALGSAGDTVTVFGLPMVLNDYSGQVFPPLIAA
IGLYWVEKGLKKIIPEAVQMVFVPFFSLLIMIPATAFLLGPFGIGVGNGISNLLEAINNFSPFILSIVIPLLYPFLVPLG
LHWPLNAIMIQNINTLGYDFIQGPMGAWNFACFGLVTGVFLLSIKERNKAMRQVSLGGMLAGLLGGISEPSLYGVLLRFK
KTYFRLLPGCLAGGIVMGIFDIKAYAFVFTSLLTIPAMDPWLGYTIGIAVAFFVSMFLVLALDYRSNEERDEARAKVAAD
KQAEEDLKAEANATPAAPVAAAGAGAGAGAGAAAGAATAVAAKPKLAAGEVVDIVSPLEGKAIPLSEVPDPIFAAGKLGP
GIAIQPTGNTVVAPADATVILVQKSGHAVALRLDSGVEILVHVGLDTVQLGGEGFTVHVERRQQVKAGDPLITFDADFIR
SKDLPLITPVVVSNAAKFGEIEGIPADQANSSTTVIKVNGKNE
>Mature_682_residues
ASKLTTTSQHILENLGGPDNITSMTHCATRLRFQVKDQSIVDQQEIDSDPSVLGVVPQGSTGMQVVMGGSVANYYQEILK
LDGMKHFADGEATESSSKKEYGGVRGKYSWIDYAFEFLSDTFRPILWALLGASLIITLLVLADTFGLQDFRAPMDEQPDT
YVFLHSMWRSVFYFLPIMVGATAARKLGANEWIGAAIPAALLTPEFLALGSAGDTVTVFGLPMVLNDYSGQVFPPLIAAI
GLYWVEKGLKKIIPEAVQMVFVPFFSLLIMIPATAFLLGPFGIGVGNGISNLLEAINNFSPFILSIVIPLLYPFLVPLGL
HWPLNAIMIQNINTLGYDFIQGPMGAWNFACFGLVTGVFLLSIKERNKAMRQVSLGGMLAGLLGGISEPSLYGVLLRFKK
TYFRLLPGCLAGGIVMGIFDIKAYAFVFTSLLTIPAMDPWLGYTIGIAVAFFVSMFLVLALDYRSNEERDEARAKVAADK
QAEEDLKAEANATPAAPVAAAGAGAGAGAGAAAGAATAVAAKPKLAAGEVVDIVSPLEGKAIPLSEVPDPIFAAGKLGPG
IAIQPTGNTVVAPADATVILVQKSGHAVALRLDSGVEILVHVGLDTVQLGGEGFTVHVERRQQVKAGDPLITFDADFIRS
KDLPLITPVVVSNAAKFGEIEGIPADQANSSTTVIKVNGKNE

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain

Homologues:

Organism=Escherichia coli, GI1790159, Length=676, Percent_Identity=29.1420118343195, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI48994906, Length=488, Percent_Identity=28.2786885245902, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI2367362, Length=434, Percent_Identity=26.7281105990783, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1788757, Length=147, Percent_Identity=41.4965986394558, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1786894, Length=129, Percent_Identity=40.3100775193798, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1788769, Length=427, Percent_Identity=27.1662763466042, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTN3B_CORGL (Q46072)

Other databases:

- EMBL:   L18874
- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600576.1
- RefSeq:   YP_225645.1
- ProteinModelPortal:   Q46072
- GeneID:   1019335
- GeneID:   3344282
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1537
- KEGG:   cgl:NCgl1305
- HOGENOM:   HBG673521
- OMA:   LENNNAP
- PhylomeDB:   Q46072
- ProtClustDB:   CLSK633359
- BioCyc:   CGLU196627:CG1537-MONOMER
- BRENDA:   2.7.1.69
- InterPro:   IPR011055
- InterPro:   IPR018113
- InterPro:   IPR001127
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- Gene3D:   G3DSA:3.30.1360.60
- TIGRFAMs:   TIGR00830

Pfam domain/function: PF00358 PTS_EIIA_1; PF00367 PTS_EIIB; PF02378 PTS_EIIC; SSF51261 Dup_hybrid_motif; SSF55604 PTS_EIIB

EC number: =2.7.1.69

Molecular weight: Translated: 72572; Mature: 72441

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS51093 PTS_EIIA_TYPE_1; PS00371 PTS_EIIA_TYPE_1_HIS; PS51098 PTS_EIIB_TYPE_1; PS01035 PTS_EIIB_TYPE_1_CYS; PS51103 PTS_EIIC_TYPE_1

Important sites: ACT_SITE 28-28 ACT_SITE 602-602

Signals:

None

Transmembrane regions:

HASH(0x1373be50)-; HASH(0x403dc4f0)-; HASH(0x10a18ab8)-; HASH(0x10627220)-; HASH(0x139711e8)-; HASH(0x106d2db8)-; HASH(0x1344d8b4)-; HASH(0x121e78fc)-; HASH(0x13337588)-; HASH(0x11d656c4)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKLTTTSQHILENLGGPDNITSMTHCATRLRFQVKDQSIVDQQEIDSDPSVLGVVPQG
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCHHHCCHHHCCCCCCEEEEECCC
STGMQVVMGGSVANYYQEILKLDGMKHFADGEATESSSKKEYGGVRGKYSWIDYAFEFLS
CCCCEEEECCHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHH
DTFRPILWALLGASLIITLLVLADTFGLQDFRAPMDEQPDTYVFLHSMWRSVFYFLPIMV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GATAARKLGANEWIGAAIPAALLTPEFLALGSAGDTVTVFGLPMVLNDYSGQVFPPLIAA
HHHHHHHCCCCCCHHHHHHHHHHCHHHHEECCCCCEEEEEECHHHEECCCCCCHHHHHHH
IGLYWVEKGLKKIIPEAVQMVFVPFFSLLIMIPATAFLLGPFGIGVGNGISNLLEAINNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SPFILSIVIPLLYPFLVPLGLHWPLNAIMIQNINTLGYDFIQGPMGAWNFACFGLVTGVF
CHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCHHCHHHHCCCCCCHHHHHHHHHHHHH
LLSIKERNKAMRQVSLGGMLAGLLGGISEPSLYGVLLRFKKTYFRLLPGCLAGGIVMGIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKAYAFVFTSLLTIPAMDPWLGYTIGIAVAFFVSMFLVLALDYRSNEERDEARAKVAAD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KQAEEDLKAEANATPAAPVAAAGAGAGAGAGAAAGAATAVAAKPKLAAGEVVDIVSPLEG
HHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCHHCHHHHHHCCCCCCCCCHHHHHCCCCC
KAIPLSEVPDPIFAAGKLGPGIAIQPTGNTVVAPADATVILVQKSGHAVALRLDSGVEIL
CCCCHHHCCCCCEECCCCCCCEEEECCCCEEEECCCEEEEEEECCCCEEEEEECCCCEEE
VHVGLDTVQLGGEGFTVHVERRQQVKAGDPLITFDADFIRSKDLPLITPVVVSNAAKFGE
EEECCCEEEECCCCEEEEECCHHHCCCCCCEEEECHHHHCCCCCCEECHHHHHCCHHCCC
IEGIPADQANSSTTVIKVNGKNE
CCCCCCCCCCCCEEEEEECCCCH
>Mature Secondary Structure 
ASKLTTTSQHILENLGGPDNITSMTHCATRLRFQVKDQSIVDQQEIDSDPSVLGVVPQG
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCHHHCCHHHCCCCCCEEEEECCC
STGMQVVMGGSVANYYQEILKLDGMKHFADGEATESSSKKEYGGVRGKYSWIDYAFEFLS
CCCCEEEECCHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHH
DTFRPILWALLGASLIITLLVLADTFGLQDFRAPMDEQPDTYVFLHSMWRSVFYFLPIMV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GATAARKLGANEWIGAAIPAALLTPEFLALGSAGDTVTVFGLPMVLNDYSGQVFPPLIAA
HHHHHHHCCCCCCHHHHHHHHHHCHHHHEECCCCCEEEEEECHHHEECCCCCCHHHHHHH
IGLYWVEKGLKKIIPEAVQMVFVPFFSLLIMIPATAFLLGPFGIGVGNGISNLLEAINNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SPFILSIVIPLLYPFLVPLGLHWPLNAIMIQNINTLGYDFIQGPMGAWNFACFGLVTGVF
CHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCHHCHHHHCCCCCCHHHHHHHHHHHHH
LLSIKERNKAMRQVSLGGMLAGLLGGISEPSLYGVLLRFKKTYFRLLPGCLAGGIVMGIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKAYAFVFTSLLTIPAMDPWLGYTIGIAVAFFVSMFLVLALDYRSNEERDEARAKVAAD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KQAEEDLKAEANATPAAPVAAAGAGAGAGAGAAAGAATAVAAKPKLAAGEVVDIVSPLEG
HHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCHHCHHHHHHCCCCCCCCCHHHHHCCCCC
KAIPLSEVPDPIFAAGKLGPGIAIQPTGNTVVAPADATVILVQKSGHAVALRLDSGVEIL
CCCCHHHCCCCCEECCCCCCCEEEECCCCEEEECCCEEEEEEECCCCEEEEEECCCCEEE
VHVGLDTVQLGGEGFTVHVERRQQVKAGDPLITFDADFIRSKDLPLITPVVVSNAAKFGE
EEECCCEEEECCCCEEEEECCHHHCCCCCCEEEECHHHHCCCCCCEECHHHHHCCHHCCC
IEGIPADQANSSTTVIKVNGKNE
CCCCCCCCCCCCEEEEEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8039653; 12948626