Click here to switch to the map view.

The map label for this gene is folP2 [H]

Identifier: 62390001

GI number: 62390001

Start: 1159144

End: 1159995

Strand: Direct

Name: folP2 [H]

Synonym: cg1262

Alternate gene names: 62390001

Gene position: 1159144-1159995 (Clockwise)

Preceding gene: 62390000

Following gene: 62390002

Centisome position: 35.31

GC content: 56.69

Gene sequence:

>852_bases
GTGGCTACATTAGGTGTTATGAGTTCTTTGCCGGTCATCATGGCCATCGTCAATCGCACCCCGGATTCTTTCTATGACAA
GGGTGCGACATTTGAGGACACCGCTGCGCTAAACAGGGCAGCGGAGGTCATTGAACAAGGCGCCGGCATTGTCGATATCG
GTGGGGTGAAAGCCGGCCCGGGGGATTTCGTGTCGGCGGAGGAAGAGATCGACCGCGTGGTGCCAATCATCGCTGCGGTG
CGAGAACGTTTTCCTGACATTGATATTTCTGTTGATACCTGGCGGGCGTCGGTGGCTGATGTCGCAGTGGCGCATGGAGC
AACGCTGATCAATGACACTTGGGCCGGCCATGATCATGAGTTGGTGCAGGTAGCAGGGCAGCACAAGGTGGGTTATGTCT
GCTCGCACACCGGCGGGGTGATTCCAAGAACGCGACCATATCGGGTGCATTTCGATGACATCGTGGCCGATGTAATTACG
GAGACCACCAAATTGGCAGAGCAAGCTGTTCGTGCCGGGGTGCCAGAGGAACGGGTGTTTATTGATCCCACCCATGATTT
CGGGAAAAACACCTTCCACGGACTGGAGCTTTTACGACGGATCGATGAGGTGGTTGCCACGGGCTGGCCGGTGCTGATGG
CCTTGAGTAATAAGGATTTCATTGGGGAAACTTTGGAAAGGGGCGTCGATAAGCGTGTTGCTGGCACGCTTGCTGCCACT
GCCTGGGCGGCGGCGCGCGGCGTTGCGGCTTTTCGCGTGCATGAAGTTGCGGAAACCTTTGACGTTTTGCAGATGACGGC
GGCGATTATGGGCGATGTGGCGCCACTTAACACCATTCGGGGGCTTGCGTGA

Upstream 100 bases:

>100_bases
TGTTGACCGGATGTTGGTCACTGATGACCTGGATCAGGCCGTCAAATTCATCGTCGATGCACACGCTGGATTGGACGTAG
CGCGTCGCCACAATTAAGCA

Downstream 100 bases:

>100_bases
GCAGCGTAAGCGTGGTGATTCCTGCGCTCAACGAAGCTCCAACCGTGGCCAAAGTCGTGGAGGCGGTCCTCGCTGACAAC
CCACTGGAAGTGCTGGTCAT

Product: dihydropteroate synthase

Products: diphosphate; dihydropteroate

Alternate protein names: DHPS 2; Dihydropteroate pyrophosphorylase 2 [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MATLGVMSSLPVIMAIVNRTPDSFYDKGATFEDTAALNRAAEVIEQGAGIVDIGGVKAGPGDFVSAEEEIDRVVPIIAAV
RERFPDIDISVDTWRASVADVAVAHGATLINDTWAGHDHELVQVAGQHKVGYVCSHTGGVIPRTRPYRVHFDDIVADVIT
ETTKLAEQAVRAGVPEERVFIDPTHDFGKNTFHGLELLRRIDEVVATGWPVLMALSNKDFIGETLERGVDKRVAGTLAAT
AWAAARGVAAFRVHEVAETFDVLQMTAAIMGDVAPLNTIRGLA

Sequences:

>Translated_283_residues
MATLGVMSSLPVIMAIVNRTPDSFYDKGATFEDTAALNRAAEVIEQGAGIVDIGGVKAGPGDFVSAEEEIDRVVPIIAAV
RERFPDIDISVDTWRASVADVAVAHGATLINDTWAGHDHELVQVAGQHKVGYVCSHTGGVIPRTRPYRVHFDDIVADVIT
ETTKLAEQAVRAGVPEERVFIDPTHDFGKNTFHGLELLRRIDEVVATGWPVLMALSNKDFIGETLERGVDKRVAGTLAAT
AWAAARGVAAFRVHEVAETFDVLQMTAAIMGDVAPLNTIRGLA
>Mature_282_residues
ATLGVMSSLPVIMAIVNRTPDSFYDKGATFEDTAALNRAAEVIEQGAGIVDIGGVKAGPGDFVSAEEEIDRVVPIIAAVR
ERFPDIDISVDTWRASVADVAVAHGATLINDTWAGHDHELVQVAGQHKVGYVCSHTGGVIPRTRPYRVHFDDIVADVITE
TTKLAEQAVRAGVPEERVFIDPTHDFGKNTFHGLELLRRIDEVVATGWPVLMALSNKDFIGETLERGVDKRVAGTLAATA
WAAARGVAAFRVHEVAETFDVLQMTAAIMGDVAPLNTIRGLA

Specific function: Has very low affinity for the DHPS substrate 6- hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=263, Percent_Identity=34.2205323193916, Blast_Score=145, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=29.8412698412698, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: 2.5.1.15

Molecular weight: Translated: 30346; Mature: 30215

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLGVMSSLPVIMAIVNRTPDSFYDKGATFEDTAALNRAAEVIEQGAGIVDIGGVKAGP
CCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GDFVSAEEEIDRVVPIIAAVRERFPDIDISVDTWRASVADVAVAHGATLINDTWAGHDHE
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEECCCCCCCCHH
LVQVAGQHKVGYVCSHTGGVIPRTRPYRVHFDDIVADVITETTKLAEQAVRAGVPEERVF
HHHHHCCCCCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
IDPTHDFGKNTFHGLELLRRIDEVVATGWPVLMALSNKDFIGETLERGVDKRVAGTLAAT
ECCCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHH
AWAAARGVAAFRVHEVAETFDVLQMTAAIMGDVAPLNTIRGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
ATLGVMSSLPVIMAIVNRTPDSFYDKGATFEDTAALNRAAEVIEQGAGIVDIGGVKAGP
CCHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GDFVSAEEEIDRVVPIIAAVRERFPDIDISVDTWRASVADVAVAHGATLINDTWAGHDHE
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEECCCCCCCCHH
LVQVAGQHKVGYVCSHTGGVIPRTRPYRVHFDDIVADVITETTKLAEQAVRAGVPEERVF
HHHHHCCCCCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
IDPTHDFGKNTFHGLELLRRIDEVVATGWPVLMALSNKDFIGETLERGVDKRVAGTLAAT
ECCCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHH
AWAAARGVAAFRVHEVAETFDVLQMTAAIMGDVAPLNTIRGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.0015 {4-aminobenzoate}} [C]

Substrates: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate; 4-aminobenzoate

Specific reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate

General reaction: Aryl group transfer [C]

Inhibitor: Sulfaguanidine; Sulfanilamide; Sulfathiazole; Sulfonamides [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]