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The map label for this gene is pth1

Identifier: 62389829

GI number: 62389829

Start: 996312

End: 996845

Strand: Reverse

Name: pth1

Synonym: cg1071

Alternate gene names: 62389829

Gene position: 996845-996312 (Counterclockwise)

Preceding gene: 62389830

Following gene: 62389825

Centisome position: 30.37

GC content: 52.43

Gene sequence:

>534_bases
GTGAATAACTCTCCCCTTTTAGTTGTTGGCCTGGGAAATCCCGGCCCGAAATACGTTGGCACCCGCCACAATATTGGCTT
TGAGGTTGCAGAAGAACTAGTGTCGCGCAGCTTTGGATCATTTAGTGTGCACAAGCGCTCCAACACCGATATCGCGCAGC
TTCCTGGGCTAATTGTGGCCAAGCCGCGCAGCTTTATGAACCTGTCGGGAACTCCGATTCGGGCGCTGTGTGACTTCTTT
AAGATTTCCCCAGCCAATGTCATCGTGGTGCATGATGAATTGGAGCTTGATTTCGGCTCAGTGAAGCTACGTCAGGGTGG
CGGGGATCATGGGCACAATGGTCTGAAATCCACGTCCAAATCTTTGGGAACTAAGGACTATTGGAAGCTCAGCATGGGTA
TCGGTAGGCCACCGGGTCGGATGGATCCGGCAAGTTTTGTGTTGAAGCCTTTTGGCAAGCAAGAACTGGCGGATATTCCC
ATCATGGCGGCTGACGCTGCAGATCTCGTCGAAAAGCATTTGCAGCAGGGCTAG

Upstream 100 bases:

>100_bases
AAATTTAAAGTGATGACAGTGCACGATCATCATGGAGGTTTCCTCACATGGTGGCGGGGCCTGTTTTTGCTTGTGGTGGA
CTCATGGTTGGATGGGGGAT

Downstream 100 bases:

>100_bases
CTACTTGCGCCGCGCCTCTTTGAGGCGGCGCGGCAGGTCGGCGTCGTCGTTTTCTAAGACCCCGGATTTGAGTAAGCGTG
TGTACACCACTGGGCAGTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH 1

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MNNSPLLVVGLGNPGPKYVGTRHNIGFEVAEELVSRSFGSFSVHKRSNTDIAQLPGLIVAKPRSFMNLSGTPIRALCDFF
KISPANVIVVHDELELDFGSVKLRQGGGDHGHNGLKSTSKSLGTKDYWKLSMGIGRPPGRMDPASFVLKPFGKQELADIP
IMAADAADLVEKHLQQG

Sequences:

>Translated_177_residues
MNNSPLLVVGLGNPGPKYVGTRHNIGFEVAEELVSRSFGSFSVHKRSNTDIAQLPGLIVAKPRSFMNLSGTPIRALCDFF
KISPANVIVVHDELELDFGSVKLRQGGGDHGHNGLKSTSKSLGTKDYWKLSMGIGRPPGRMDPASFVLKPFGKQELADIP
IMAADAADLVEKHLQQG
>Mature_177_residues
MNNSPLLVVGLGNPGPKYVGTRHNIGFEVAEELVSRSFGSFSVHKRSNTDIAQLPGLIVAKPRSFMNLSGTPIRALCDFF
KISPANVIVVHDELELDFGSVKLRQGGGDHGHNGLKSTSKSLGTKDYWKLSMGIGRPPGRMDPASFVLKPFGKQELADIP
IMAADAADLVEKHLQQG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=177, Percent_Identity=32.7683615819209, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1787455, Length=184, Percent_Identity=36.9565217391304, Blast_Score=80, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321983, Length=179, Percent_Identity=34.0782122905028, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH1_CORGL (Q8NRV3)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927150
- RefSeq:   NP_600166.1
- RefSeq:   YP_225231.1
- ProteinModelPortal:   Q8NRV3
- SMR:   Q8NRV3
- GeneID:   1018930
- GeneID:   3343697
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1071
- KEGG:   cgl:NCgl0901
- HOGENOM:   HBG610927
- OMA:   GDHGHNG
- PhylomeDB:   Q8NRV3
- ProtClustDB:   PRK05426
- BioCyc:   CGLU196627:CG1071-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 19077; Mature: 19077

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSPLLVVGLGNPGPKYVGTRHNIGFEVAEELVSRSFGSFSVHKRSNTDIAQLPGLIVA
CCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHCCCEEEE
KPRSFMNLSGTPIRALCDFFKISPANVIVVHDELELDFGSVKLRQGGGDHGHNGLKSTSK
CCCHHCCCCCCCHHHHHHHHHCCCCCEEEEECCEECCCCEEEEECCCCCCCCCCHHHHHH
SLGTKDYWKLSMGIGRPPGRMDPASFVLKPFGKQELADIPIMAADAADLVEKHLQQG
HCCCCCEEEEECCCCCCCCCCCHHHHHHCCCCCCHHHCCCEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MNNSPLLVVGLGNPGPKYVGTRHNIGFEVAEELVSRSFGSFSVHKRSNTDIAQLPGLIVA
CCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHCCCEEEE
KPRSFMNLSGTPIRALCDFFKISPANVIVVHDELELDFGSVKLRQGGGDHGHNGLKSTSK
CCCHHCCCCCCCHHHHHHHHHCCCCCEEEEECCEECCCCEEEEECCCCCCCCCCHHHHHH
SLGTKDYWKLSMGIGRPPGRMDPASFVLKPFGKQELADIPIMAADAADLVEKHLQQG
HCCCCCEEEEECCCCCCCCCCCHHHHHHCCCCCCHHHCCCEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626