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The map label for this gene is pth2 [H]

Identifier: 62389825

GI number: 62389825

Start: 992884

End: 993489

Strand: Reverse

Name: pth2 [H]

Synonym: cg1067

Alternate gene names: 62389825

Gene position: 993489-992884 (Counterclockwise)

Preceding gene: 62389829

Following gene: 62389819

Centisome position: 30.26

GC content: 59.41

Gene sequence:

>606_bases
GTGAGTTTTTTGTCTAAAATCCAAGCACTGTTTGCCCCCAAGCCTGAACTTCCCGCCGCCAAATGGCTGGTCGTGGGCCT
GGGCAACCCCGGCGCCAAGTACGAATCCACCCGACACAACGTCGGTTACATGTGCCAAGACATGCTTATCGACGCCCACC
AGCAGCAGCCCCTCACCCCCGCCACGGGCTACAAGGCCCTCACAACGCAGCTCGCACCAGGGGTGCTCGCCGTTCGATCC
ACCACTTTTATGAACCACTCCGGCCAAGGTGTCGCACCGATCGCCGCAGCGTTGGGTATCCCAGCAGAGCGCATCATCGT
GATCCACGACGAGCTCGATCTGCCCGCTGGAAAAGTACGCCTGAAAAAGGGCGGAAACGAAAACGGTCACAACGGCCTGA
AATCCCTCACGGAAGAGCTCGGCACCAGAGACTACCTGCGCGTCCGCATCGGCATTTCACGACCACCAGCAGGAATGGCC
GTGCCCGACTACGTTTTGGAACCAGTCGATCACGACCAACCAGGCATTGAACTTGCCGCCGAGGCAGTGGATTTGCTGCT
GGCCCAGGGATTATCTGCTGCGCAAAACGCTATCCACAGCCGCTAG

Upstream 100 bases:

>100_bases
GACGGGCCGCCAGCCATCGGGGCGACAATCACGGGAGTTTTCAACGTGTCAAGGATGCTCATGGCACCATCCTAGGCGCG
CCTGCCATAGGATGACTTCC

Downstream 100 bases:

>100_bases
ATTGCTAGAGATTCCCGCACTTTAGTCTGCTTCTCTGCGGTGGTTTCAGCGCCTTGTCCCGATTCCACGACCTGACCACG
CGCCACAATGGCGTAGCTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH 2 [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSFLSKIQALFAPKPELPAAKWLVVGLGNPGAKYESTRHNVGYMCQDMLIDAHQQQPLTPATGYKALTTQLAPGVLAVRS
TTFMNHSGQGVAPIAAALGIPAERIIVIHDELDLPAGKVRLKKGGNENGHNGLKSLTEELGTRDYLRVRIGISRPPAGMA
VPDYVLEPVDHDQPGIELAAEAVDLLLAQGLSAAQNAIHSR

Sequences:

>Translated_201_residues
MSFLSKIQALFAPKPELPAAKWLVVGLGNPGAKYESTRHNVGYMCQDMLIDAHQQQPLTPATGYKALTTQLAPGVLAVRS
TTFMNHSGQGVAPIAAALGIPAERIIVIHDELDLPAGKVRLKKGGNENGHNGLKSLTEELGTRDYLRVRIGISRPPAGMA
VPDYVLEPVDHDQPGIELAAEAVDLLLAQGLSAAQNAIHSR
>Mature_200_residues
SFLSKIQALFAPKPELPAAKWLVVGLGNPGAKYESTRHNVGYMCQDMLIDAHQQQPLTPATGYKALTTQLAPGVLAVRST
TFMNHSGQGVAPIAAALGIPAERIIVIHDELDLPAGKVRLKKGGNENGHNGLKSLTEELGTRDYLRVRIGISRPPAGMAV
PDYVLEPVDHDQPGIELAAEAVDLLLAQGLSAAQNAIHSR

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=167, Percent_Identity=35.3293413173653, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=39.0374331550802, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321983, Length=147, Percent_Identity=34.6938775510204, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21408; Mature: 21277

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLSKIQALFAPKPELPAAKWLVVGLGNPGAKYESTRHNVGYMCQDMLIDAHQQQPLTP
CCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
ATGYKALTTQLAPGVLAVRSTTFMNHSGQGVAPIAAALGIPAERIIVIHDELDLPAGKVR
CCCHHHHHHHHCCCEEEEHHHHEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEE
LKKGGNENGHNGLKSLTEELGTRDYLRVRIGISRPPAGMAVPDYVLEPVDHDQPGIELAA
EECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCHHHHH
EAVDLLLAQGLSAAQNAIHSR
HHHHHHHHHCHHHHHHHHCCC
>Mature Secondary Structure 
SFLSKIQALFAPKPELPAAKWLVVGLGNPGAKYESTRHNVGYMCQDMLIDAHQQQPLTP
CHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
ATGYKALTTQLAPGVLAVRSTTFMNHSGQGVAPIAAALGIPAERIIVIHDELDLPAGKVR
CCCHHHHHHHHCCCEEEEHHHHEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEE
LKKGGNENGHNGLKSLTEELGTRDYLRVRIGISRPPAGMAVPDYVLEPVDHDQPGIELAA
EECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCHHHHH
EAVDLLLAQGLSAAQNAIHSR
HHHHHHHHHCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]