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The map label for this gene is livM [H]

Identifier: 62389822

GI number: 62389822

Start: 990374

End: 991453

Strand: Direct

Name: livM [H]

Synonym: cg1064

Alternate gene names: 62389822

Gene position: 990374-991453 (Clockwise)

Preceding gene: 62389821

Following gene: 62389823

Centisome position: 30.17

GC content: 56.2

Gene sequence:

>1080_bases
ATGAGCACTCAACTCAAGCTGAAGAAGCCCGCAAAGAAGAAAACTACGCCGAAACTTAGCGTCGTAAATGCTCCCACGCT
GCGCACTGCGGCGTTGGGCCTGGCCGCGCTCGCTGCGGTATTGCTGTGCGCCCCGCTCTTTTTATCCACATTCCAGCTGA
CGTTGATGTCGCGCTTGGTGTGTTATGCGATCGTCGCAGTCGGCATCGGGCTGGCGTGGGGCAGAGGCGGCATGCTCACG
CTGGGGCAAGGCGTGTTCTTTGGAATCGGCGCGTACATCATGGCCATGCACATGCTGTACAGCGATTCGCAGATTTTTGG
GACCACAGTTCCGCAATGGTGGTCCATTTTTGCCAACCCGGCAGTCGCACTCATCGCAGTTGTGGCGCTTCCCGGCATCG
TGGCTTTTGTGCTCGGCTTCTCCATTTTCAAACGACGCATCAAAGGCGCCTACTTTGCCATCGTGAACCAAGCGCTCGCC
GCAGCTGTTGTGGTGTTGCTGGTCGGACAACAAGATTCCCTTGGAGGTTCCAATGGTCTTTCCGGATTTCGATCGTTCAT
GGGTTTTGCCGTCTACGACCCCATCAACCGCATCATGTTTTACTTCACCGCAGTGGGAGTTCTCTTGGCTTTGGTGGCTA
TCTCATATTGGCTCATGCGCAGCCGCTATGGAGAACTGCTCGTGGCCACCAGAGATGCAGAAGAACGCGTCCGATTCCTC
GGATATGATCCCGCATTGATCAAAACCGCCGCATATGTCATTGCTGCGATGATTGCCGGAATCGCCGGAGCGCTGTTCGT
GCCGATCGTGGGCATCATTTCACCCGCAGAAATCGGCGTGGTGCCATCAATCGTGTTCGTGATCGCCGTCGCCGCTGGTG
GCAGGGCATCCCTATTCGGTCCCGTAGTTGGCGCGCTGGTGCTGGGCTGGGTGGAATCCACACTTGCTCAAACTTTCCCC
AGCATGTGGTCCTATTTCCAGGGTGCGATCCTGGTTCTCGTGATCGTGTTGCTGCCGGGCGGAATTGCTTCAATTAAACT
TTCCGCGCTCAAAAATAAGGCCAGGAAGGCCACCTCATGA

Upstream 100 bases:

>100_bases
CAGGTGCGAGCATCGCGAAGTTCATCGTACTCATCGCTGTTGTTGCCTTCCTGCAGTTTAGGCCTCAAGGACTCTTCCAA
ACCCAAACTAGGAGCCTCGT

Downstream 100 bases:

>100_bases
GCCTTAAAATCACCAACCTCAAAGTCGCTTTCGGGTCGTTCATCGCCGTGAATGAGATTAGTTTTCAGGTGCTGCCCGGT
CACGTCCACTTCCTCATCGG

Product: branched chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSTQLKLKKPAKKKTTPKLSVVNAPTLRTAALGLAALAAVLLCAPLFLSTFQLTLMSRLVCYAIVAVGIGLAWGRGGMLT
LGQGVFFGIGAYIMAMHMLYSDSQIFGTTVPQWWSIFANPAVALIAVVALPGIVAFVLGFSIFKRRIKGAYFAIVNQALA
AAVVVLLVGQQDSLGGSNGLSGFRSFMGFAVYDPINRIMFYFTAVGVLLALVAISYWLMRSRYGELLVATRDAEERVRFL
GYDPALIKTAAYVIAAMIAGIAGALFVPIVGIISPAEIGVVPSIVFVIAVAAGGRASLFGPVVGALVLGWVESTLAQTFP
SMWSYFQGAILVLVIVLLPGGIASIKLSALKNKARKATS

Sequences:

>Translated_359_residues
MSTQLKLKKPAKKKTTPKLSVVNAPTLRTAALGLAALAAVLLCAPLFLSTFQLTLMSRLVCYAIVAVGIGLAWGRGGMLT
LGQGVFFGIGAYIMAMHMLYSDSQIFGTTVPQWWSIFANPAVALIAVVALPGIVAFVLGFSIFKRRIKGAYFAIVNQALA
AAVVVLLVGQQDSLGGSNGLSGFRSFMGFAVYDPINRIMFYFTAVGVLLALVAISYWLMRSRYGELLVATRDAEERVRFL
GYDPALIKTAAYVIAAMIAGIAGALFVPIVGIISPAEIGVVPSIVFVIAVAAGGRASLFGPVVGALVLGWVESTLAQTFP
SMWSYFQGAILVLVIVLLPGGIASIKLSALKNKARKATS
>Mature_358_residues
STQLKLKKPAKKKTTPKLSVVNAPTLRTAALGLAALAAVLLCAPLFLSTFQLTLMSRLVCYAIVAVGIGLAWGRGGMLTL
GQGVFFGIGAYIMAMHMLYSDSQIFGTTVPQWWSIFANPAVALIAVVALPGIVAFVLGFSIFKRRIKGAYFAIVNQALAA
AVVVLLVGQQDSLGGSNGLSGFRSFMGFAVYDPINRIMFYFTAVGVLLALVAISYWLMRSRYGELLVATRDAEERVRFLG
YDPALIKTAAYVIAAMIAGIAGALFVPIVGIISPAEIGVVPSIVFVIAVAAGGRASLFGPVVGALVLGWVESTLAQTFPS
MWSYFQGAILVLVIVLLPGGIASIKLSALKNKARKATS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=332, Percent_Identity=28.6144578313253, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 37873; Mature: 37742

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQLKLKKPAKKKTTPKLSVVNAPTLRTAALGLAALAAVLLCAPLFLSTFQLTLMSRLV
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CYAIVAVGIGLAWGRGGMLTLGQGVFFGIGAYIMAMHMLYSDSQIFGTTVPQWWSIFANP
HHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHCCH
AVALIAVVALPGIVAFVLGFSIFKRRIKGAYFAIVNQALAAAVVVLLVGQQDSLGGSNGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SGFRSFMGFAVYDPINRIMFYFTAVGVLLALVAISYWLMRSRYGELLVATRDAEERVRFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHC
GYDPALIKTAAYVIAAMIAGIAGALFVPIVGIISPAEIGVVPSIVFVIAVAAGGRASLFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
PVVGALVLGWVESTLAQTFPSMWSYFQGAILVLVIVLLPGGIASIKLSALKNKARKATS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STQLKLKKPAKKKTTPKLSVVNAPTLRTAALGLAALAAVLLCAPLFLSTFQLTLMSRLV
CCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CYAIVAVGIGLAWGRGGMLTLGQGVFFGIGAYIMAMHMLYSDSQIFGTTVPQWWSIFANP
HHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHCCH
AVALIAVVALPGIVAFVLGFSIFKRRIKGAYFAIVNQALAAAVVVLLVGQQDSLGGSNGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SGFRSFMGFAVYDPINRIMFYFTAVGVLLALVAISYWLMRSRYGELLVATRDAEERVRFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHC
GYDPALIKTAAYVIAAMIAGIAGALFVPIVGIISPAEIGVVPSIVFVIAVAAGGRASLFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
PVVGALVLGWVESTLAQTFPSMWSYFQGAILVLVIVLLPGGIASIKLSALKNKARKATS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]