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The map label for this gene is cgtR2 [H]

Identifier: 62389763

GI number: 62389763

Start: 929518

End: 930285

Strand: Direct

Name: cgtR2 [H]

Synonym: cg0996

Alternate gene names: 62389763

Gene position: 929518-930285 (Clockwise)

Preceding gene: 62389762

Following gene: 62389764

Centisome position: 28.32

GC content: 51.43

Gene sequence:

>768_bases
ATGTTCCAACGCGTGGACGTCTTAATTGGGAGGAAGTCTGTCACGGACTGGAAGACGAAAAGGGTATCGATGAAAATTTT
AGTTGTTGATGACGAGCAAGCTGTACGTGACTCCTTGCGACGTTCCCTTTCGTTCAACGGATACAACGTTGTTCTCGCAG
AAGACGGCATCCAAGCACTAGAGATGATTGACAAGGAACAGCCTGCTTTGGTGATCCTCGATGTCATGATGCCTGGTATG
GACGGACTTGAGGTCTGTCGCCACCTTCGCAGCGAAGGCGATGATCGGCCAATTCTTATTCTTACTGCCCGCGATAATGT
TTCTGATCGTGTTGGTGGCCTCGATGCAGGCGCAGATGACTATTTGGCTAAACCATTTGCTCTTGAAGAGCTGTTGGCGC
GCGTCCGTTCACTGGTGCGTCGCTCTGCAGTGGAATCAAATCAGAGTTCCAGCATTGAACAGGCTCTATTATCTTGTGGC
GATTTGACGCTTGACCCAGAAAGTCGAGATGTCTACCGCAACGGACGCGCCATCAGCCTTACTCGAACAGAGTTCGCGCT
CCTGCAATTGCTCCTCAAAAACCAAAGGAAAGTGCTCACTCGCGCCCAGATTTTGGAAGAGGTATGGGGCTGCGATTTCC
CCACTTCAGGCAATGCCCTCGAGGTCTACATTGGATACCTTCGACGCAAGACTGAATTGGAAGGAGAAGACCGCCTGATC
CATACAGTACGAGGAGTCGGATACGTCCTGCGAGAGACCGCTCCGTGA

Upstream 100 bases:

>100_bases
CCTTTTGTAGGTAAGAATTTAACAAGAGCCAGTTATCTTCTCTTAAAATGAGGAGGTAACTGGCTTCTTTATGCTTAAGA
GGTGTTAGCATAAGTGAAAT

Downstream 100 bases:

>100_bases
CATTAAGGCGAATCGGCGCAGGGGAAAATGGGCCTGCCCCTACCGAAAGTGATGACTCCGACGGTTCAATGTCGTTGCGT
TGGCGCTTGGCTTTGCTGAG

Product: two component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MFQRVDVLIGRKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQALEMIDKEQPALVILDVMMPGM
DGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADDYLAKPFALEELLARVRSLVRRSAVESNQSSSIEQALLSCG
DLTLDPESRDVYRNGRAISLTRTEFALLQLLLKNQRKVLTRAQILEEVWGCDFPTSGNALEVYIGYLRRKTELEGEDRLI
HTVRGVGYVLRETAP

Sequences:

>Translated_255_residues
MFQRVDVLIGRKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQALEMIDKEQPALVILDVMMPGM
DGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADDYLAKPFALEELLARVRSLVRRSAVESNQSSSIEQALLSCG
DLTLDPESRDVYRNGRAISLTRTEFALLQLLLKNQRKVLTRAQILEEVWGCDFPTSGNALEVYIGYLRRKTELEGEDRLI
HTVRGVGYVLRETAP
>Mature_255_residues
MFQRVDVLIGRKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQALEMIDKEQPALVILDVMMPGM
DGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADDYLAKPFALEELLARVRSLVRRSAVESNQSSSIEQALLSCG
DLTLDPESRDVYRNGRAISLTRTEFALLQLLLKNQRKVLTRAQILEEVWGCDFPTSGNALEVYIGYLRRKTELEGEDRLI
HTVRGVGYVLRETAP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=42.7312775330396, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=41.3333333333333, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=41.9213973799127, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=37.6106194690265, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=39.1111111111111, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=39.647577092511, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=37.4449339207048, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=32.5991189427313, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.1578947368421, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.5132743362832, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.4372294372294, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787487, Length=133, Percent_Identity=37.593984962406, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=163, Percent_Identity=30.6748466257669, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790299, Length=148, Percent_Identity=29.7297297297297, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=39.1304347826087, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=37.3134328358209, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=38.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788521, Length=125, Percent_Identity=35.2, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=35.8490566037736, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788905, Length=124, Percent_Identity=29.8387096774194, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28661; Mature: 28661

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQRVDVLIGRKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQAL
CCCCEEEEECCCCCCCHHHEEEEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCHHHH
EMIDKEQPALVILDVMMPGMDGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADD
HHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCHH
YLAKPFALEELLARVRSLVRRSAVESNQSSSIEQALLSCGDLTLDPESRDVYRNGRAISL
HHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCHHHHHCCCEEEE
TRTEFALLQLLLKNQRKVLTRAQILEEVWGCDFPTSGNALEVYIGYLRRKTELEGEDRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
HTVRGVGYVLRETAP
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQRVDVLIGRKSVTDWKTKRVSMKILVVDDEQAVRDSLRRSLSFNGYNVVLAEDGIQAL
CCCCEEEEECCCCCCCHHHEEEEEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCHHHH
EMIDKEQPALVILDVMMPGMDGLEVCRHLRSEGDDRPILILTARDNVSDRVGGLDAGADD
HHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCHH
YLAKPFALEELLARVRSLVRRSAVESNQSSSIEQALLSCGDLTLDPESRDVYRNGRAISL
HHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCHHHHHCCCEEEE
TRTEFALLQLLLKNQRKVLTRAQILEEVWGCDFPTSGNALEVYIGYLRRKTELEGEDRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
HTVRGVGYVLRETAP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA