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The map label for this gene is accBC [H]

Identifier: 62389589

GI number: 62389589

Start: 720050

End: 721825

Strand: Reverse

Name: accBC [H]

Synonym: cg0802

Alternate gene names: 62389589

Gene position: 721825-720050 (Counterclockwise)

Preceding gene: 62389590

Following gene: 62389587

Centisome position: 21.99

GC content: 58.67

Gene sequence:

>1776_bases
GTGTCAGTCGAGACTAGGAAGATCACCAAGGTTCTTGTCGCTAACCGTGGTGAGATTGCAATCCGCGTGTTCCGTGCAGC
TCGAGATGAAGGCATCGGATCTGTCGCCGTCTACGCAGAGCCAGATGCAGATGCACCATTCGTGTCATATGCAGACGAGG
CTTTTGCCCTCGGTGGCCAAACATCCGCTGAGTCCTACCTTGTCATTGACAAGATCATCGATGCGGCCCGCAAGTCCGGC
GCCGACGCCATCCACCCCGGCTACGGCTTCCTCGCAGAAAACGCTGACTTCGCAGAAGCAGTCATCAACGAAGGCCTGAT
CTGGATTGGACCTTCACCTGAGTCCATCCGCTCCCTCGGCGACAAGGTCACCGCTCGCCACATCGCAGATACCGCCAAGG
CTCCAATGGCTCCTGGCACCAAGGAACCAGTAAAAGACGCAGCAGAAGTTGTGGCTTTCGCTGAAGAATTCGGTCTCCCA
ATCGCCATCAAGGCAGCTTTCGGTGGCGGCGGACGTGGCATGAAGGTTGCCTACAAGATGGAAGAAGTCGCTGACCTCTT
CGAGTCCGCAACCCGTGAAGCAACCGCAGCGTTCGGCCGCGGCGAGTGCTTCGTGGAGCGCTACCTGGACAAGGCACGCC
ACGTTGAGGCTCAGGTCATCGCCGATAAGCACGGCAACGTTGTTGTCGCCGGAACCCGTGACTGCTCCCTGCAGCGCCGT
TTCCAGAAGCTCGTCGAAGAAGCACCAGCACCATTCCTCACCGATGACCAGCGCGAGCGTCTCCACTCCTCCGCGAAGGC
TATCTGTAAGGAAGCTGGCTACTACGGTGCAGGCACCGTTGAGTACCTCGTTGGCTCCGACGGCCTGATCTCCTTCCTCG
AGGTCAACACCCGCCTCCAGGTGGAACACCCAGTCACCGAAGAGACCACCGGCATCGACCTGGTCCGCGAAATGTTCCGC
ATCGCAGAAGGCCACGAGCTCTCCATCAAGGAAGATCCAGCTCCACGCGGCCACGCATTCGAGTTCCGCATCAACGGCGA
AGACGCTGGCTCCAACTTCATGCCTGCACCAGGCAAGATCACCAGCTACCGCGAGCCACAGGGCCCAGGCGTCCGCATGG
ACTCCGGTGTCGTTGAAGGTTCCGAAATCTCCGGACAGTTCGACTCCATGCTGGCAAAGCTGATCGTTTGGGGCGACACC
CGCGAGCAGGCTCTCCAGCGCTCCCGCCGTGCACTTGCAGAGTACGTTGTCGAGGGCATGCCAACCGTTATCCCATTCCA
CCAGCACATCGTGGAAAACCCAGCATTCGTGGGCAACGACGAAGGCTTCGAGATCTACACCAAGTGGATCGAAGAGGTTT
GGGATAACCCAATCGCACCTTACGTTGACGCTTCCGAGCTCGACGAAGATGAGGACAAGACCCCAGCACAGAAGGTTGTT
GTGGAGATCAACGGCCGTCGCGTTGAGGTTGCACTCCCAGGCGATCTGGCACTCGGTGGCACCGCTGGTCCTAAGAAGAA
GGCCAAGAAGCGTCGCGCAGGTGGTGCAAAGGCTGGCGTATCCGGCGATGCAGTGGCAGCTCCAATGCAGGGCACTGTCA
TCAAGGTCAACGTCGAAGAAGGCGCTGAAGTCAACGAAGGCGACACCGTTGTTGTCCTCGAGGCTATGAAGATGGAAAAC
CCTGTGAAGGCTCATAAGTCCGGAACCGTAACCGGCCTTACTGTCGCTGCAGGCGAGGGTGTCAACAAGGGCGTTGTTCT
CCTCGAGATCAAGTAA

Upstream 100 bases:

>100_bases
TGGTTGAGTTCTTCGGGGTTGAGTGTGCAAGAATATTCACTATTGGTCAGGCAACTATGTGTCTACCCACTGAGTCATCA
ATTTAAATCAGGAGTTATTA

Downstream 100 bases:

>100_bases
GTTCTTGGATTCCTGTTAGTCAAAAACCGGGTCGCATCTGATGTTCAGATGTGGCCCGGTTTTACTATTTGTGAATACAC
TCTGCCCCTGTTGTACATTC

Product: biotin carboxylase and biotin carboxyl carrier protein

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MSVETRKITKVLVANRGEIAIRVFRAARDEGIGSVAVYAEPDADAPFVSYADEAFALGGQTSAESYLVIDKIIDAARKSG
ADAIHPGYGFLAENADFAEAVINEGLIWIGPSPESIRSLGDKVTARHIADTAKAPMAPGTKEPVKDAAEVVAFAEEFGLP
IAIKAAFGGGGRGMKVAYKMEEVADLFESATREATAAFGRGECFVERYLDKARHVEAQVIADKHGNVVVAGTRDCSLQRR
FQKLVEEAPAPFLTDDQRERLHSSAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEETTGIDLVREMFR
IAEGHELSIKEDPAPRGHAFEFRINGEDAGSNFMPAPGKITSYREPQGPGVRMDSGVVEGSEISGQFDSMLAKLIVWGDT
REQALQRSRRALAEYVVEGMPTVIPFHQHIVENPAFVGNDEGFEIYTKWIEEVWDNPIAPYVDASELDEDEDKTPAQKVV
VEINGRRVEVALPGDLALGGTAGPKKKAKKRRAGGAKAGVSGDAVAAPMQGTVIKVNVEEGAEVNEGDTVVVLEAMKMEN
PVKAHKSGTVTGLTVAAGEGVNKGVVLLEIK

Sequences:

>Translated_591_residues
MSVETRKITKVLVANRGEIAIRVFRAARDEGIGSVAVYAEPDADAPFVSYADEAFALGGQTSAESYLVIDKIIDAARKSG
ADAIHPGYGFLAENADFAEAVINEGLIWIGPSPESIRSLGDKVTARHIADTAKAPMAPGTKEPVKDAAEVVAFAEEFGLP
IAIKAAFGGGGRGMKVAYKMEEVADLFESATREATAAFGRGECFVERYLDKARHVEAQVIADKHGNVVVAGTRDCSLQRR
FQKLVEEAPAPFLTDDQRERLHSSAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEETTGIDLVREMFR
IAEGHELSIKEDPAPRGHAFEFRINGEDAGSNFMPAPGKITSYREPQGPGVRMDSGVVEGSEISGQFDSMLAKLIVWGDT
REQALQRSRRALAEYVVEGMPTVIPFHQHIVENPAFVGNDEGFEIYTKWIEEVWDNPIAPYVDASELDEDEDKTPAQKVV
VEINGRRVEVALPGDLALGGTAGPKKKAKKRRAGGAKAGVSGDAVAAPMQGTVIKVNVEEGAEVNEGDTVVVLEAMKMEN
PVKAHKSGTVTGLTVAAGEGVNKGVVLLEIK
>Mature_590_residues
SVETRKITKVLVANRGEIAIRVFRAARDEGIGSVAVYAEPDADAPFVSYADEAFALGGQTSAESYLVIDKIIDAARKSGA
DAIHPGYGFLAENADFAEAVINEGLIWIGPSPESIRSLGDKVTARHIADTAKAPMAPGTKEPVKDAAEVVAFAEEFGLPI
AIKAAFGGGGRGMKVAYKMEEVADLFESATREATAAFGRGECFVERYLDKARHVEAQVIADKHGNVVVAGTRDCSLQRRF
QKLVEEAPAPFLTDDQRERLHSSAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEETTGIDLVREMFRI
AEGHELSIKEDPAPRGHAFEFRINGEDAGSNFMPAPGKITSYREPQGPGVRMDSGVVEGSEISGQFDSMLAKLIVWGDTR
EQALQRSRRALAEYVVEGMPTVIPFHQHIVENPAFVGNDEGFEIYTKWIEEVWDNPIAPYVDASELDEDEDKTPAQKVVV
EINGRRVEVALPGDLALGGTAGPKKKAKKRRAGGAKAGVSGDAVAAPMQGTVIKVNVEEGAEVNEGDTVVVLEAMKMENP
VKAHKSGTVTGLTVAAGEGVNKGVVLLEIK

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI295821183, Length=626, Percent_Identity=38.0191693290735, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI116805327, Length=449, Percent_Identity=43.8752783964365, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI189095269, Length=448, Percent_Identity=44.4196428571429, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI65506442, Length=452, Percent_Identity=44.0265486725664, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=44.7368421052632, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=44.7368421052632, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=44.7368421052632, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI38679960, Length=507, Percent_Identity=29.7830374753452, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679977, Length=507, Percent_Identity=29.7830374753452, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679967, Length=507, Percent_Identity=29.7830374753452, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679971, Length=507, Percent_Identity=29.7830374753452, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679974, Length=507, Percent_Identity=29.7830374753452, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=30.1181102362205, Blast_Score=214, Evalue=2e-55,
Organism=Escherichia coli, GI1789654, Length=439, Percent_Identity=46.2414578587699, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1786216, Length=405, Percent_Identity=22.962962962963, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=451, Percent_Identity=43.6807095343681, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71987519, Length=447, Percent_Identity=45.1901565995526, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=441, Percent_Identity=45.8049886621315, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=27.4747474747475, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=28.0464216634429, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=27.852998065764, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319695, Length=457, Percent_Identity=45.7330415754923, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321376, Length=457, Percent_Identity=46.6083150984683, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=41.1214953271028, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6323863, Length=486, Percent_Identity=29.8353909465021, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=28.6821705426357, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24652212, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=441, Percent_Identity=46.9387755102041, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651757, Length=464, Percent_Identity=42.4568965517241, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=415, Percent_Identity=42.1686746987952, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=29.6222664015905, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=29.6222664015905, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=29.6222664015905, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=29.6222664015905, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 63420; Mature: 63289

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVETRKITKVLVANRGEIAIRVFRAARDEGIGSVAVYAEPDADAPFVSYADEAFALGGQ
CCCCHHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEEEEECCCCCCCHHHHCCHHHCCCCC
TSAESYLVIDKIIDAARKSGADAIHPGYGFLAENADFAEAVINEGLIWIGPSPESIRSLG
CCCCCEEHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCHHHHHHHH
DKVTARHIADTAKAPMAPGTKEPVKDAAEVVAFAEEFGLPIAIKAAFGGGGRGMKVAYKM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEHH
EEVADLFESATREATAAFGRGECFVERYLDKARHVEAQVIADKHGNVVVAGTRDCSLQRR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCHHHHH
FQKLVEEAPAPFLTDDQRERLHSSAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQ
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEEE
VEHPVTEETTGIDLVREMFRIAEGHELSIKEDPAPRGHAFEFRINGEDAGSNFMPAPGKI
ECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
TSYREPQGPGVRMDSGVVEGSEISGQFDSMLAKLIVWGDTREQALQRSRRALAEYVVEGM
CCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCC
PTVIPFHQHIVENPAFVGNDEGFEIYTKWIEEVWDNPIAPYVDASELDEDEDKTPAQKVV
CCEEHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCEEEE
VEINGRRVEVALPGDLALGGTAGPKKKAKKRRAGGAKAGVSGDAVAAPMQGTVIKVNVEE
EEECCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEECCC
GAEVNEGDTVVVLEAMKMENPVKAHKSGTVTGLTVAAGEGVNKGVVLLEIK
CCCCCCCCEEEEEEEHHCCCCHHHCCCCCEEEEEEEECCCCCCCEEEEEEC
>Mature Secondary Structure 
SVETRKITKVLVANRGEIAIRVFRAARDEGIGSVAVYAEPDADAPFVSYADEAFALGGQ
CCCHHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEEEEECCCCCCCHHHHCCHHHCCCCC
TSAESYLVIDKIIDAARKSGADAIHPGYGFLAENADFAEAVINEGLIWIGPSPESIRSLG
CCCCCEEHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCHHHHHHHH
DKVTARHIADTAKAPMAPGTKEPVKDAAEVVAFAEEFGLPIAIKAAFGGGGRGMKVAYKM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEHH
EEVADLFESATREATAAFGRGECFVERYLDKARHVEAQVIADKHGNVVVAGTRDCSLQRR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCHHHHH
FQKLVEEAPAPFLTDDQRERLHSSAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQ
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEEE
VEHPVTEETTGIDLVREMFRIAEGHELSIKEDPAPRGHAFEFRINGEDAGSNFMPAPGKI
ECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
TSYREPQGPGVRMDSGVVEGSEISGQFDSMLAKLIVWGDTREQALQRSRRALAEYVVEGM
CCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCC
PTVIPFHQHIVENPAFVGNDEGFEIYTKWIEEVWDNPIAPYVDASELDEDEDKTPAQKVV
CCEEHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCEEEE
VEINGRRVEVALPGDLALGGTAGPKKKAKKRRAGGAKAGVSGDAVAAPMQGTVIKVNVEE
EEECCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCEEEEEECCC
GAEVNEGDTVVVLEAMKMENPVKAHKSGTVTGLTVAAGEGVNKGVVLLEIK
CCCCCCCCEEEEEEEHHCCCCHHHCCCCCEEEEEEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]