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The map label for this gene is trpS

Identifier: 62389566

GI number: 62389566

Start: 693355

End: 694392

Strand: Direct

Name: trpS

Synonym: cg0779

Alternate gene names: 62389566

Gene position: 693355-694392 (Clockwise)

Preceding gene: 62389562

Following gene: 62389567

Centisome position: 21.12

GC content: 56.84

Gene sequence:

>1038_bases
ATGACGACGCAGGATAAAGATCTCACCGCACAAACCGCTTCCAGAGTCCTTTCTGGAATTCAGCCCACCGCCGATTCCTA
TCACCTGGGCAATTACTTGGGAGCAGTCAAGCAGTGGATTGACCTGCAAGATTCCTACGATGCCTTCTACTTCATTCCAG
ATCTCCACGCGATTACCGTCGATCAGGAACCAGAAGAGCTGCGCAACCGCACCATTTCCGGCGCCGCACAGCTGCTGGCC
CTGGGCATTGATCCAGAACGCTCCACCTTGTTTGTGCAGTCGCATGTTCCCGCACATGCAGAACTGTCATGGGTTCTGAC
CTGCCTGACCGGTTTCGGCGAGGCATCCCGCATGACCCAGTTCAAGGACAAGTCCTCCAAGCGTGGCGCCGACCGTACCT
CAGCTGGTCTGTTCACCTACCCGATGCTGATGGCAGCAGATATTTTGCTGTACCGCCCACATCTTGTCCCAGTCGGTGAA
GATCAGCGCCAGCACCTGGAGCTCACCCGCACCCTCGCGGAGCGTTTCAACAATCGTTTCGGCAAGGCCTTCGAGGTTCC
AGAAGGATTCATCCCGCAGGGCGCATCCAAGATTTACGATCTGCAGAACCCCACCGCCAAGATGTCCAAGTCCGGCGACA
ACCCGAAGGGCATCATCAACCTGCTTGATGATCCAAAGGTGTCCACCAAGCGCATCAAGTCCGCAGTCACCGACAACGAC
GGCGTCATCGCCTACGATCCAGAAAACAAGCCTGGCGTGTCCAACTTGCTGGTCATCCAGTCTGCGCTGACGGGTACCTC
CATCGATTCGCTTGTCGACGGCTACCAGGGCGCTGGCTACGGTGCGTTGAAGGGTGACACCGCCGACGCGCTTGAGGCTT
TCACCACTCCTTTGAAGGCAAAGTACGACGAGTACATGAATGACCGCGGCGAGCTCGAACGAGTCTTGGCTATCGGTGCT
GAGCGCGCCACCGAAGTTGCCAACGAAACCTTGGCTGATGTGTACGACAAGATTGGTTTCTTGGCGTCTCGTCGCTAA

Upstream 100 bases:

>100_bases
TGAACAAAACCCTAAACTTTCGGCCGATAGCAACCCCGCTCGACTGGTAAATGTTGCCTCACCGGAAAAGGTCTGTCCAA
GGTGACTACACTGATACAGC

Downstream 100 bases:

>100_bases
CAACTAGACCCTCGATTATTACAATCCGGCTACTTCGGAAGCGTTTGTGGCCGGATTTTTCTATCCTGGAAGGTATTAAT
ACTTCTTTAAGGGTCGGAGG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTTQDKDLTAQTASRVLSGIQPTADSYHLGNYLGAVKQWIDLQDSYDAFYFIPDLHAITVDQEPEELRNRTISGAAQLLA
LGIDPERSTLFVQSHVPAHAELSWVLTCLTGFGEASRMTQFKDKSSKRGADRTSAGLFTYPMLMAADILLYRPHLVPVGE
DQRQHLELTRTLAERFNNRFGKAFEVPEGFIPQGASKIYDLQNPTAKMSKSGDNPKGIINLLDDPKVSTKRIKSAVTDND
GVIAYDPENKPGVSNLLVIQSALTGTSIDSLVDGYQGAGYGALKGDTADALEAFTTPLKAKYDEYMNDRGELERVLAIGA
ERATEVANETLADVYDKIGFLASRR

Sequences:

>Translated_345_residues
MTTQDKDLTAQTASRVLSGIQPTADSYHLGNYLGAVKQWIDLQDSYDAFYFIPDLHAITVDQEPEELRNRTISGAAQLLA
LGIDPERSTLFVQSHVPAHAELSWVLTCLTGFGEASRMTQFKDKSSKRGADRTSAGLFTYPMLMAADILLYRPHLVPVGE
DQRQHLELTRTLAERFNNRFGKAFEVPEGFIPQGASKIYDLQNPTAKMSKSGDNPKGIINLLDDPKVSTKRIKSAVTDND
GVIAYDPENKPGVSNLLVIQSALTGTSIDSLVDGYQGAGYGALKGDTADALEAFTTPLKAKYDEYMNDRGELERVLAIGA
ERATEVANETLADVYDKIGFLASRR
>Mature_344_residues
TTQDKDLTAQTASRVLSGIQPTADSYHLGNYLGAVKQWIDLQDSYDAFYFIPDLHAITVDQEPEELRNRTISGAAQLLAL
GIDPERSTLFVQSHVPAHAELSWVLTCLTGFGEASRMTQFKDKSSKRGADRTSAGLFTYPMLMAADILLYRPHLVPVGED
QRQHLELTRTLAERFNNRFGKAFEVPEGFIPQGASKIYDLQNPTAKMSKSGDNPKGIINLLDDPKVSTKRIKSAVTDNDG
VIAYDPENKPGVSNLLVIQSALTGTSIDSLVDGYQGAGYGALKGDTADALEAFTTPLKAKYDEYMNDRGELERVLAIGAE
RATEVANETLADVYDKIGFLASRR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=335, Percent_Identity=42.3880597014925, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI41352700, Length=185, Percent_Identity=50.8108108108108, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1789786, Length=329, Percent_Identity=54.4072948328268, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71982800, Length=331, Percent_Identity=36.8580060422961, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71982793, Length=331, Percent_Identity=36.8580060422961, Blast_Score=211, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=39.5953757225434, Blast_Score=226, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24666151, Length=328, Percent_Identity=43.9024390243902, Blast_Score=269, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_CORGL (Q8NSJ4)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927149
- RefSeq:   NP_599909.1
- RefSeq:   YP_224968.1
- ProteinModelPortal:   Q8NSJ4
- SMR:   Q8NSJ4
- GeneID:   1018676
- GeneID:   3344474
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0779
- KEGG:   cgl:NCgl0647
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- PhylomeDB:   Q8NSJ4
- ProtClustDB:   PRK00927
- BioCyc:   CGLU196627:CG0779-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 37827; Mature: 37696

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 210-210

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQDKDLTAQTASRVLSGIQPTADSYHLGNYLGAVKQWIDLQDSYDAFYFIPDLHAITV
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEC
DQEPEELRNRTISGAAQLLALGIDPERSTLFVQSHVPAHAELSWVLTCLTGFGEASRMTQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHH
FKDKSSKRGADRTSAGLFTYPMLMAADILLYRPHLVPVGEDQRQHLELTRTLAERFNNRF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GKAFEVPEGFIPQGASKIYDLQNPTAKMSKSGDNPKGIINLLDDPKVSTKRIKSAVTDND
CCEECCCCCCCCCCHHHHCCCCCCHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
GVIAYDPENKPGVSNLLVIQSALTGTSIDSLVDGYQGAGYGALKGDTADALEAFTTPLKA
CEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHH
KYDEYMNDRGELERVLAIGAERATEVANETLADVYDKIGFLASRR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTQDKDLTAQTASRVLSGIQPTADSYHLGNYLGAVKQWIDLQDSYDAFYFIPDLHAITV
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEC
DQEPEELRNRTISGAAQLLALGIDPERSTLFVQSHVPAHAELSWVLTCLTGFGEASRMTQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHH
FKDKSSKRGADRTSAGLFTYPMLMAADILLYRPHLVPVGEDQRQHLELTRTLAERFNNRF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GKAFEVPEGFIPQGASKIYDLQNPTAKMSKSGDNPKGIINLLDDPKVSTKRIKSAVTDND
CCEECCCCCCCCCCHHHHCCCCCCHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
GVIAYDPENKPGVSNLLVIQSALTGTSIDSLVDGYQGAGYGALKGDTADALEAFTTPLKA
CEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHH
KYDEYMNDRGELERVLAIGAERATEVANETLADVYDKIGFLASRR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626