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The map label for this gene is metX

Identifier: 62389542

GI number: 62389542

Start: 666641

End: 667774

Strand: Reverse

Name: metX

Synonym: cg0754

Alternate gene names: 62389542

Gene position: 667774-666641 (Counterclockwise)

Preceding gene: 62389543

Following gene: 62389541

Centisome position: 20.34

GC content: 55.82

Gene sequence:

>1134_bases
ATGCCCACCCTCGCGCCTTCAGGTCAACTTGAAATCCAAGCGATCGGTGATGTCTCCACCGAAGCCGGAGCAATCATTAC
AAACGCTGAAATCGCCTATCACCGCTGGGGTGAATACCGCGTAGATAAAGAAGGACGCAGCAATGTCGTTCTCATCGAAC
ACGCCCTCACTGGAGATTCCAACGCAGCCGATTGGTGGGCTGACTTGCTCGGTCCCGGCAAAGCCATCAACACTGATATT
TACTGCGTGATCTGTACCAACGTCATCGGTGGTTGCAACGGTTCCACCGGACCTGGCTCCATGCATCCAGATGGAAATTT
CTGGGGTAATCGCTTCCCCGCCACGTCCATTCGTGATCAGGTAAACGCCGAAAAACAATTCCTCGACGCACTCGGCATCA
CCACGGTCGCCGCAGTACTTGGTGGTTCCATGGGTGGTGCCCGCACCCTAGAGTGGGCCGCAATGTACCCAGAAACTGTT
GGCGCAGCTGCTGTTCTTGCAGTTTCTGCACGCGCCAGCGCCTGGCAAATCGGCATTCAATCCGCCCAAATTAAGGCGAT
TGAAAACGACCACCACTGGCACGAAGGCAACTACTACGAATCCGGCTGCAACCCAGCCACCGGACTCGGCGCCGCCCGAC
GCATCGCCCACCTCACCTACCGTGGCGAACTAGAAATCGACGAACGCTTCGGCACCAAAGCCCAAAAGAACGAAAACCCA
CTCGGTCCCTACCGCAAGCCCGACCAGCGCTTCGCCGTGGAATCCTACTTGGACTACCAAGCAGACAAGCTAGTACAGCG
TTTCGACGCCGGCTCCTACGTCTTGCTCACCGACGCCCTCAACCGCCACGACATTGGTCGCGACCGCGGAGGCCTCAACA
AGGCACTCGAATCCATCAAAGTTCCAGTCCTTGTCGCAGGCGTAGATACCGATATTTTGTACCCCTACCACCAGCAAGAA
CACCTCTCCAGAAACCTGGGAAATCTACTGGCAATGGCAAAAATCGTATCCCCTGTCGGCCACGATGCTTTCCTCACCGA
AAGCCGCCAAATGGATCGCATCGTGAGGAACTTCTTCAGCCTCATCTCCCCAGACGAAGACAACCCTTCGACCTACATCG
AGTTCTACATCTAA

Upstream 100 bases:

>100_bases
TTTTTCAGACTCGTGAGAATGCAAACTAGACTAGACAGAGCTGTCCATATACACTGGACGAAGTTTTAGTCTTGTCCACC
CAGAACAGGCGGTTATTTTC

Downstream 100 bases:

>100_bases
TAGGTATTTACGACAAATAGACAGGGATCTCTAAACAACTCACAGGCAACCCTCCGGATAAACCAAAAAACAATCTCTAA
CATAAGTAGTTGTGACTTTG

Product: homoserine O-acetyltransferase

Products: NA

Alternate protein names: Homoserine O-trans-acetylase; HTA; Homoserine transacetylase

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPTLAPSGQLEIQAIGDVSTEAGAIITNAEIAYHRWGEYRVDKEGRSNVVLIEHALTGDSNAADWWADLLGPGKAINTDI
YCVICTNVIGGCNGSTGPGSMHPDGNFWGNRFPATSIRDQVNAEKQFLDALGITTVAAVLGGSMGGARTLEWAAMYPETV
GAAAVLAVSARASAWQIGIQSAQIKAIENDHHWHEGNYYESGCNPATGLGAARRIAHLTYRGELEIDERFGTKAQKNENP
LGPYRKPDQRFAVESYLDYQADKLVQRFDAGSYVLLTDALNRHDIGRDRGGLNKALESIKVPVLVAGVDTDILYPYHQQE
HLSRNLGNLLAMAKIVSPVGHDAFLTESRQMDRIVRNFFSLISPDEDNPSTYIEFYI

Sequences:

>Translated_377_residues
MPTLAPSGQLEIQAIGDVSTEAGAIITNAEIAYHRWGEYRVDKEGRSNVVLIEHALTGDSNAADWWADLLGPGKAINTDI
YCVICTNVIGGCNGSTGPGSMHPDGNFWGNRFPATSIRDQVNAEKQFLDALGITTVAAVLGGSMGGARTLEWAAMYPETV
GAAAVLAVSARASAWQIGIQSAQIKAIENDHHWHEGNYYESGCNPATGLGAARRIAHLTYRGELEIDERFGTKAQKNENP
LGPYRKPDQRFAVESYLDYQADKLVQRFDAGSYVLLTDALNRHDIGRDRGGLNKALESIKVPVLVAGVDTDILYPYHQQE
HLSRNLGNLLAMAKIVSPVGHDAFLTESRQMDRIVRNFFSLISPDEDNPSTYIEFYI
>Mature_376_residues
PTLAPSGQLEIQAIGDVSTEAGAIITNAEIAYHRWGEYRVDKEGRSNVVLIEHALTGDSNAADWWADLLGPGKAINTDIY
CVICTNVIGGCNGSTGPGSMHPDGNFWGNRFPATSIRDQVNAEKQFLDALGITTVAAVLGGSMGGARTLEWAAMYPETVG
AAAVLAVSARASAWQIGIQSAQIKAIENDHHWHEGNYYESGCNPATGLGAARRIAHLTYRGELEIDERFGTKAQKNENPL
GPYRKPDQRFAVESYLDYQADKLVQRFDAGSYVLLTDALNRHDIGRDRGGLNKALESIKVPVLVAGVDTDILYPYHQQEH
LSRNLGNLLAMAKIVSPVGHDAFLTESRQMDRIVRNFFSLISPDEDNPSTYIEFYI

Specific function: Unknown

COG id: COG2021

COG function: function code E; Homoserine acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HTA family

Homologues:

Organism=Saccharomyces cerevisiae, GI6324052, Length=246, Percent_Identity=39.8373983739837, Blast_Score=160, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): METX_CORGL (O68640)

Other databases:

- EMBL:   AF052652
- EMBL:   BA000036
- EMBL:   BX927149
- RefSeq:   NP_599885.1
- RefSeq:   YP_224944.1
- ProteinModelPortal:   O68640
- SMR:   O68640
- World-2DPAGE:   0001:O68640
- PRIDE:   O68640
- GeneID:   1018653
- GeneID:   3343119
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0754
- KEGG:   cgl:NCgl0624
- HOGENOM:   HBG692920
- OMA:   VSFTSDW
- PhylomeDB:   O68640
- ProtClustDB:   PRK00175
- BioCyc:   CGLU196627:CG0754-MONOMER
- BioCyc:   MetaCyc:MONOMER-9447
- BRENDA:   2.3.1.31
- GO:   GO:0005737
- HAMAP:   MF_00296
- InterPro:   IPR000073
- InterPro:   IPR008220
- PIRSF:   PIRSF000443
- TIGRFAMs:   TIGR01392

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =2.3.1.31

Molecular weight: Translated: 41179; Mature: 41047

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: ACT_SITE 143-143 ACT_SITE 341-341

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLAPSGQLEIQAIGDVSTEAGAIITNAEIAYHRWGEYRVDKEGRSNVVLIEHALTGDS
CCCCCCCCCEEEEECCCCCCCCCEEEECCEEEEEECCCEEECCCCCCCEEEEEEEECCCC
NAADWWADLLGPGKAINTDIYCVICTNVIGGCNGSTGPGSMHPDGNFWGNRFPATSIRDQ
CHHHHHHHHCCCCCEECCCEEEEEECCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VNAEKQFLDALGITTVAAVLGGSMGGARTLEWAAMYPETVGAAAVLAVSARASAWQIGIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHCCHHHHHHHHHHHHCCCCEEEEECC
SAQIKAIENDHHWHEGNYYESGCNPATGLGAARRIAHLTYRGELEIDERFGTKAQKNENP
CEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCEEEHHHCCCCCCCCCCC
LGPYRKPDQRFAVESYLDYQADKLVQRFDAGSYVLLTDALNRHDIGRDRGGLNKALESIK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCCCHHHHHHHHCC
VPVLVAGVDTDILYPYHQQEHLSRNLGNLLAMAKIVSPVGHDAFLTESRQMDRIVRNFFS
CCEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LISPDEDNPSTYIEFYI
HCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
PTLAPSGQLEIQAIGDVSTEAGAIITNAEIAYHRWGEYRVDKEGRSNVVLIEHALTGDS
CCCCCCCCEEEEECCCCCCCCCEEEECCEEEEEECCCEEECCCCCCCEEEEEEEECCCC
NAADWWADLLGPGKAINTDIYCVICTNVIGGCNGSTGPGSMHPDGNFWGNRFPATSIRDQ
CHHHHHHHHCCCCCEECCCEEEEEECCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VNAEKQFLDALGITTVAAVLGGSMGGARTLEWAAMYPETVGAAAVLAVSARASAWQIGIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHCCHHHHHHHHHHHHCCCCEEEEECC
SAQIKAIENDHHWHEGNYYESGCNPATGLGAARRIAHLTYRGELEIDERFGTKAQKNENP
CEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCEEEHHHCCCCCCCCCCC
LGPYRKPDQRFAVESYLDYQADKLVQRFDAGSYVLLTDALNRHDIGRDRGGLNKALESIK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCCCHHHHHHHHCC
VPVLVAGVDTDILYPYHQQEHLSRNLGNLLAMAKIVSPVGHDAFLTESRQMDRIVRNFFS
CCEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LISPDEDNPSTYIEFYI
HCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9666465; 12948626