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The map label for this gene is phr [H]

Identifier: 62389521

GI number: 62389521

Start: 644014

End: 645462

Strand: Reverse

Name: phr [H]

Synonym: cg0728

Alternate gene names: 62389521

Gene position: 645462-644014 (Counterclockwise)

Preceding gene: 62389523

Following gene: 62389519

Centisome position: 19.66

GC content: 46.24

Gene sequence:

>1449_bases
ATGAATGCAAACGCAAGGGTGTTTATTTTAAACTCATTAGCTATGAATGATCCACAACGCTCTCCCACCCTTCTATGGTT
CCGCGATGACCTCCGACTAAGTGATAATGCTGCCTTAAAATGGGCTGCTGATCATGGCCCCGTTATTGGACTCTTCATTG
ATGAAACGATCAATCGCAGCATTGGGGCCGCAGCACGATGGTGGCGAGAACAAAGCCTTAATGCTTTAGCCCAAGATCTT
TCTTTTTACGGAGTACCTTTACTACGACGTACCGGTAATCCGCTTGAAATACTGCCGAAAATAGTCTCTGAGATGGAAGT
CAAAGCCGTCACATGGAATCGACGCTATCATCAACCGTTATGTGAAGTGGATGCCACTCTCAAAAAGAATCTCCGTGATA
AAGGGATTGAAGTGCATAGCCACCCAGGTTTTTTACTCACTGAACCCTGGGAAGTCAGTACCGCTACCGGAACTCCCTAC
AAGGTATTTACCCCTTTTTCTAAAGCCGCATGGGAAGTAGCCAGAGTACATGCATATGAAACTGTTAAAAACAATGTGCC
TGTCCCCTCTCACCTAACAGGACCAGAGGATGTAGAGCTGCCCATCCTAGAAATGGAGCAACCTTTTTGGTCAACAACGT
TAGTTAAGGAGTGTGCTCCCGGTGAAAAAAATGCTTCGGAAAAACTCTTTGATTTTTTGGAACATCTACAGGACTACCCG
CAAGCTCGAGACAGCTTAGCCCGATCCGCTACAAGTAAATTATCTGCTCATCTAAGGTTTGGTGAGATCAGCATCCACCG
CGTGTGGGCAGAGACTGCAGCAATAGACTCTGAAGGAACTGAGTTATTTCTTAAAGAACTTCTCTGGAGAGATTTTGCGT
GGCATCGACTTTATGCCCTGCCACACATGGACACGCAAAACGTTCGTATGCAATTTAATCGTTTCGGATGGTCCTGGGAT
CCGAGTGAAAAAGATAAACTTAACACTCCATCCACCCCTCTTATCCCCACCAAAGCTGACCAATTCCATGAGGATTTAGC
AGCATGGCGTGCAGGAAAAACAGGAATTCCGCTGGTCGATGCAGGCATGCGAGAATTATGGGCCACCGGGTCAATGCACA
ATCGCGTCAGAATGGTAGTAGCTAGTTTTTTAACCAAGAATCTCCAGATCCATTGGCGTCATGGCGAAGAATGGTTTTGG
GAAACTCTCGTAGATGCTGATCCAGCTTCTAATGCTTTCAACTGGCAATGGGCTGCGGGTAGCGGAGATGACGCTTCGCC
TTATTTCCGTATTTTTAATCCGGTCACCCAAGCGAAAAAATTTGATCCAGATGAAACTTATATTCGTCGCTGGGTACCCG
AATATGGAACACCATCATATCCGGATCCCATCGTCGATCTGAAAGAATCCCGTCAAATTGCTTTAGACGCCTACTCTGCG
ATTAAGTGA

Upstream 100 bases:

>100_bases
AGCACTGTTCTAGAAGTACTGCATCATTTAGACATGGAATTACGATACTGATTCTGCGTTGGATTGAGGTTGTCATAAAT
CTGGCTTTCTCCACGGTTGA

Downstream 100 bases:

>100_bases
GTTTACGCGCAGCTTTTAAAATATTCGAACGCATATAAGGAAAAATAATCGCATGGAACGGTGAAACAACCCACCAATAG
AGATAACCGGGCAAACCCTT

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNANARVFILNSLAMNDPQRSPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRSIGAAARWWREQSLNALAQDL
SFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPLCEVDATLKKNLRDKGIEVHSHPGFLLTEPWEVSTATGTPY
KVFTPFSKAAWEVARVHAYETVKNNVPVPSHLTGPEDVELPILEMEQPFWSTTLVKECAPGEKNASEKLFDFLEHLQDYP
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYALPHMDTQNVRMQFNRFGWSWD
PSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVDAGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFW
ETLVDADPASNAFNWQWAAGSGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
IK

Sequences:

>Translated_482_residues
MNANARVFILNSLAMNDPQRSPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRSIGAAARWWREQSLNALAQDL
SFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPLCEVDATLKKNLRDKGIEVHSHPGFLLTEPWEVSTATGTPY
KVFTPFSKAAWEVARVHAYETVKNNVPVPSHLTGPEDVELPILEMEQPFWSTTLVKECAPGEKNASEKLFDFLEHLQDYP
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYALPHMDTQNVRMQFNRFGWSWD
PSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVDAGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFW
ETLVDADPASNAFNWQWAAGSGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
IK
>Mature_482_residues
MNANARVFILNSLAMNDPQRSPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRSIGAAARWWREQSLNALAQDL
SFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPLCEVDATLKKNLRDKGIEVHSHPGFLLTEPWEVSTATGTPY
KVFTPFSKAAWEVARVHAYETVKNNVPVPSHLTGPEDVELPILEMEQPFWSTTLVKECAPGEKNASEKLFDFLEHLQDYP
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYALPHMDTQNVRMQFNRFGWSWD
PSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVDAGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFW
ETLVDADPASNAFNWQWAAGSGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
IK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=465, Percent_Identity=28.3870967741935, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4758072, Length=455, Percent_Identity=28.1318681318681, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI188536103, Length=424, Percent_Identity=27.5943396226415, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1786926, Length=506, Percent_Identity=34.1897233201581, Blast_Score=220, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324962, Length=527, Percent_Identity=29.6015180265655, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17137248, Length=473, Percent_Identity=27.906976744186, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585455, Length=473, Percent_Identity=27.906976744186, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648152, Length=498, Percent_Identity=27.3092369477912, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55178; Mature: 55178

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANARVFILNSLAMNDPQRSPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRS
CCCCEEEEEEECHHCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEEECHHHCHH
IGAAARWWREQSLNALAQDLSFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHEEEEEEECCHHCCCH
CEVDATLKKNLRDKGIEVHSHPGFLLTEPWEVSTATGTPYKVFTPFSKAAWEVARVHAYE
HHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
TVKNNVPVPSHLTGPEDVELPILEMEQPFWSTTLVKECAPGEKNASEKLFDFLEHLQDYP
HHHCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYAL
HHHHHHHHHHHHHHHHHEEECCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEC
PHMDTQNVRMQFNRFGWSWDPSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVD
CCCCCCHHHEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
AGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFWETLVDADPASNAFNWQWAAG
HHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEECCC
SGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
CCCCCCCCEEECCHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHCCCEEEEHHHHH
IK
CC
>Mature Secondary Structure
MNANARVFILNSLAMNDPQRSPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRS
CCCCEEEEEEECHHCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEEECHHHCHH
IGAAARWWREQSLNALAQDLSFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHEEEEEEECCHHCCCH
CEVDATLKKNLRDKGIEVHSHPGFLLTEPWEVSTATGTPYKVFTPFSKAAWEVARVHAYE
HHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
TVKNNVPVPSHLTGPEDVELPILEMEQPFWSTTLVKECAPGEKNASEKLFDFLEHLQDYP
HHHCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYAL
HHHHHHHHHHHHHHHHHEEECCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEC
PHMDTQNVRMQFNRFGWSWDPSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVD
CCCCCCHHHEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
AGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFWETLVDADPASNAFNWQWAAG
HHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEECCC
SGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
CCCCCCCCEEECCHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHCCCEEEEHHHHH
IK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]