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The map label for this gene is gltC [H]

Identifier: 62389497

GI number: 62389497

Start: 620547

End: 621458

Strand: Direct

Name: gltC [H]

Synonym: cg0702

Alternate gene names: 62389497

Gene position: 620547-621458 (Clockwise)

Preceding gene: 62389495

Following gene: 62389498

Centisome position: 18.9

GC content: 58.99

Gene sequence:

>912_bases
GTGCTCAATCTCAACCGCTTACACATCCTGCAGGAATTCCACCGCCTGGGAACGATTACAGCAGTGGCGGAATCCATGAA
CTACAGCCGCTCTGCCATCTCCCAACAAATGGCGCTGCTGGAAAAAGAAATTGGTGTGAAACTCTTTGAAAAAAGCGGCC
GAAACCTCTACTTCACAGAACAAGGCGAAGTGTTGGCCTCAGAAACACATGCGATCATGGCAGCAGTCGACCATGCCCGC
GCAGCCGTTCTAGATTCGCTGTCTGAAGTGTCCGGAACGCTGAAAGTCACCTCCTTCCAATCCCTGCTGTTCACCCTTGC
CCCGAAAGCCATCGCGCGCCTGACCGAGAAATACCCACACCTGCAAGTAGAAATCTCCCAACTAGAAGTCACCGCAGCGC
TCGAAGAACTCCGCGCCCGCCGCGTCGACGTCGCACTCGGCGAGGAATACCCCGTGGAAGTCCCCCTTGTTGAGGCCAGC
ATTCACCGCGAAGTCCTCTTCGAAGACCCCATGCTGCTCGTCACCCCAGCAAGCGGCCCATACTCTGGCCTCACCCTGCC
AGAACTCCGCGACATCCCCATCGCCATCGATCCACCCGACCTTCCCGCGGGCGAATGGGTCCATAGGCTCTGCCGGCGCG
CCGGGTTTGAGCCCCGCGTGACCTTTGAAACCAGCGATCCCATGCTCCAAGCACACCTCGTGCGTAGCGGCTTGGCCGTG
ACATTTTCCCCCACACTGCTCACCCCGATGCTGGAAAGCGTGCACATCCAGCCGCTGCCCGGCAACCCCACGCGCACGCT
CTACACCGCGGTCAGGGAAGGGCGCCAGGGGCATCCAGCCATTAAAGCTTTTCGACGAGCCCTCGCCCATGTGGCCAAAG
AATCTTATTTGGAGGCTCGTCTAGTAGAGTGA

Upstream 100 bases:

>100_bases
GTTTATTCATGCCCTTGATTATTGCCAAAGAAACCTTTAAGGACTAGATCGAAAAACAGCCAACTATAGTTAAGTAATAC
TGAACAATTTTGGAGGTGTC

Downstream 100 bases:

>100_bases
GTTCTTGTGAGCCTTCAGACAAATCATCGCCCAGTACTCGTCGTTGACTTCGGCGCACAGTACGCGCAGCTGATCGCACG
TCGTGTGCGTGAGGCCGGCA

Product: transcription regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MLNLNRLHILQEFHRLGTITAVAESMNYSRSAISQQMALLEKEIGVKLFEKSGRNLYFTEQGEVLASETHAIMAAVDHAR
AAVLDSLSEVSGTLKVTSFQSLLFTLAPKAIARLTEKYPHLQVEISQLEVTAALEELRARRVDVALGEEYPVEVPLVEAS
IHREVLFEDPMLLVTPASGPYSGLTLPELRDIPIAIDPPDLPAGEWVHRLCRRAGFEPRVTFETSDPMLQAHLVRSGLAV
TFSPTLLTPMLESVHIQPLPGNPTRTLYTAVREGRQGHPAIKAFRRALAHVAKESYLEARLVE

Sequences:

>Translated_303_residues
MLNLNRLHILQEFHRLGTITAVAESMNYSRSAISQQMALLEKEIGVKLFEKSGRNLYFTEQGEVLASETHAIMAAVDHAR
AAVLDSLSEVSGTLKVTSFQSLLFTLAPKAIARLTEKYPHLQVEISQLEVTAALEELRARRVDVALGEEYPVEVPLVEAS
IHREVLFEDPMLLVTPASGPYSGLTLPELRDIPIAIDPPDLPAGEWVHRLCRRAGFEPRVTFETSDPMLQAHLVRSGLAV
TFSPTLLTPMLESVHIQPLPGNPTRTLYTAVREGRQGHPAIKAFRRALAHVAKESYLEARLVE
>Mature_303_residues
MLNLNRLHILQEFHRLGTITAVAESMNYSRSAISQQMALLEKEIGVKLFEKSGRNLYFTEQGEVLASETHAIMAAVDHAR
AAVLDSLSEVSGTLKVTSFQSLLFTLAPKAIARLTEKYPHLQVEISQLEVTAALEELRARRVDVALGEEYPVEVPLVEAS
IHREVLFEDPMLLVTPASGPYSGLTLPELRDIPIAIDPPDLPAGEWVHRLCRRAGFEPRVTFETSDPMLQAHLVRSGLAV
TFSPTLLTPMLESVHIQPLPGNPTRTLYTAVREGRQGHPAIKAFRRALAHVAKESYLEARLVE

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=212, Percent_Identity=23.5849056603774, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787530, Length=227, Percent_Identity=23.3480176211454, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=23.7903225806452, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788887, Length=291, Percent_Identity=24.7422680412371, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788481, Length=240, Percent_Identity=24.5833333333333, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33608; Mature: 33608

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLNRLHILQEFHRLGTITAVAESMNYSRSAISQQMALLEKEIGVKLFEKSGRNLYFTE
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEC
QGEVLASETHAIMAAVDHARAAVLDSLSEVSGTLKVTSFQSLLFTLAPKAIARLTEKYPH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCC
LQVEISQLEVTAALEELRARRVDVALGEEYPVEVPLVEASIHREVLFEDPMLLVTPASGP
EEEEHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHCCCEEEEECCCCC
YSGLTLPELRDIPIAIDPPDLPAGEWVHRLCRRAGFEPRVTFETSDPMLQAHLVRSGLAV
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCEE
TFSPTLLTPMLESVHIQPLPGNPTRTLYTAVREGRQGHPAIKAFRRALAHVAKESYLEAR
EECHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVE
CCC
>Mature Secondary Structure
MLNLNRLHILQEFHRLGTITAVAESMNYSRSAISQQMALLEKEIGVKLFEKSGRNLYFTE
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEC
QGEVLASETHAIMAAVDHARAAVLDSLSEVSGTLKVTSFQSLLFTLAPKAIARLTEKYPH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCC
LQVEISQLEVTAALEELRARRVDVALGEEYPVEVPLVEASIHREVLFEDPMLLVTPASGP
EEEEHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHCCCEEEEECCCCC
YSGLTLPELRDIPIAIDPPDLPAGEWVHRLCRRAGFEPRVTFETSDPMLQAHLVRSGLAV
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCEE
TFSPTLLTPMLESVHIQPLPGNPTRTLYTAVREGRQGHPAIKAFRRALAHVAKESYLEAR
EECHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]