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The map label for this gene is groEL [H]

Identifier: 62389489

GI number: 62389489

Start: 612457

End: 613737

Strand: Direct

Name: groEL [H]

Synonym: cg0693

Alternate gene names: 62389489

Gene position: 612457-613737 (Clockwise)

Preceding gene: 62389488

Following gene: 62389491

Centisome position: 18.66

GC content: 55.04

Gene sequence:

>1281_bases
ATGGAGCTCAACAAGGGTATTTCTGCAGCTGCAGAAAAGACCTTGGAAGAGTTGAAGGCACGCGCAACCGAGGTGTCTGA
CACCAAGGAAATCGCAAACGTCGCTACCGTTTCATCCCGCGATGAAGTTGTCGGCGAGATCGTTGCTGCAGCGATGGAAA
AGGTTGGCAAGGACGGTGTCGTCACCGTTGAGGAGTCCCAGTCCATCGAGACTGCTCTCGAGGTCACCGAAGGTATTTCT
TTCGACAAGGGCTACCTTTCCCCTTATTTCATCAACGACAACGACACTCAGCAGGCTGTCCTGGACAACCCTGCAGTGCT
GCTTGTTCGCAACAAGATTTCTTCCCTCCCAGACTTCCTCCCATTGCTGGAGAAGGTTGTGGAGTCCAACCGTCCTTTGC
TGATCATCGCAGAAGACGTCGAGGGCGAGCCTTTGCAGACCCTGGTTGTGAACTCCATCCGCAAGACCATCAAGGTCGTT
GCAGTGAAGTCCCCTTACTTCGGTGACCGACGCAAGGCGTTCATGGATGACCTGGCTATTGTCACCAAGGCAACTGTCGT
GGATCCAGAAGTGGGCATCAACCTCAACGAAGCTGGCGAAGAAGTTTTCGGTACCGCACGCCGCATCACCGTTTCCAAGG
ACGAAACCATCATCGTTGATGGTGCAGGTTCCGCAGAAGACGTTGAAGCACGTCGCGGCCAGATCCGTCGCGAAATCGCC
AACACCGATTCCACCTGGGATCGCGAAAAGGCAGAAGAGCGTTTGGCTAAGCTCTCCGGTGGTATTGCTGTCATCCGCGT
TGGTGCAGCAACTGAAACCGAAGTCAACGACCGCAAGCTGCGTGTCGAAGATGCCATCAACGCTGCTCGCGCAGCAGCAC
AAGAAGGCGTTATCGCTGGTGGCGGTTCCGCTTTGGTTCAGATCGCTGAGACTCTGAAGGCTTACGCCGAAGAGTTCGAA
GGCGACCAGAAGGTCGGCGTTCGCGCACTGGCTACTGCTTTGGGCAAGCCAGCGTACTGGATCGCCTCCAACGCAGGTCT
TGACGGCTCTGTTGTTGTTGCACGCACTGCTGCTCTGCCAAACGGCGAGGGCTTCAACGCTGCAACTTTGGAATACGGAA
ACCTGATCAACGACGGTGTCATCGACCCAGTCAAGGTCACCCATTCCGCAGTAGTGAATGCAACCTCTGTTGCACGCATG
GTTCTGACCACTGAGGCTTCTGTTGTTGAGAAGCCTGCAGAAGAAGCAGCCGATGCACATGCAGGACATCATCACCACTA
A

Upstream 100 bases:

>100_bases
TCCGTAATTTGAACCACTACATTCTGCGGTGCCTTATCCATTCAGGGCAGTTGGTCCATAAGATCAATGCACTCTAAAAC
AGGAAGAGCCCGCAAACCCA

Downstream 100 bases:

>100_bases
AGTTCTGTGAAAAACACCGTGGGCAGTTTCTGCTTCGCGGTGTTTTTTATTTGTGGGGCAGAAGTGCTGGTTAGAGTTAC
TGTGCAAAAGAGCTCTGCAT

Product: 60 kDa chaperonin (protein CPN60) (GROEL protein) C-terminal fragment

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MELNKGISAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGVVTVEESQSIETALEVTEGIS
FDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVESNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVV
AVKSPYFGDRRKAFMDDLAIVTKATVVDPEVGINLNEAGEEVFGTARRITVSKDETIIVDGAGSAEDVEARRGQIRREIA
NTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAGGGSALVQIAETLKAYAEEFE
GDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAATLEYGNLINDGVIDPVKVTHSAVVNATSVARM
VLTTEASVVEKPAEEAADAHAGHHHH

Sequences:

>Translated_426_residues
MELNKGISAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGVVTVEESQSIETALEVTEGIS
FDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVESNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVV
AVKSPYFGDRRKAFMDDLAIVTKATVVDPEVGINLNEAGEEVFGTARRITVSKDETIIVDGAGSAEDVEARRGQIRREIA
NTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAGGGSALVQIAETLKAYAEEFE
GDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAATLEYGNLINDGVIDPVKVTHSAVVNATSVARM
VLTTEASVVEKPAEEAADAHAGHHHH
>Mature_426_residues
MELNKGISAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGVVTVEESQSIETALEVTEGIS
FDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFLPLLEKVVESNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVV
AVKSPYFGDRRKAFMDDLAIVTKATVVDPEVGINLNEAGEEVFGTARRITVSKDETIIVDGAGSAEDVEARRGQIRREIA
NTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAGGGSALVQIAETLKAYAEEFE
GDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALPNGEGFNAATLEYGNLINDGVIDPVKVTHSAVVNATSVARM
VLTTEASVVEKPAEEAADAHAGHHHH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=417, Percent_Identity=40.0479616306954, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI31542947, Length=417, Percent_Identity=40.0479616306954, Blast_Score=308, Evalue=7e-84,
Organism=Escherichia coli, GI1790586, Length=419, Percent_Identity=48.9260143198091, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17555558, Length=419, Percent_Identity=40.0954653937947, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=39.1509433962264, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323288, Length=416, Percent_Identity=43.9903846153846, Blast_Score=341, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24641193, Length=417, Percent_Identity=41.726618705036, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24641191, Length=417, Percent_Identity=41.726618705036, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI45550936, Length=417, Percent_Identity=40.5275779376499, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI45550132, Length=417, Percent_Identity=40.5275779376499, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI45550935, Length=417, Percent_Identity=40.5275779376499, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI17864606, Length=413, Percent_Identity=35.1089588377724, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24584129, Length=416, Percent_Identity=32.9326923076923, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI19921262, Length=416, Percent_Identity=32.9326923076923, Blast_Score=185, Evalue=7e-47,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 45255; Mature: 45255

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNKGISAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGV
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCE
VTVEESQSIETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFL
EEEECCCHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHCCCEEEEEECHHHCCHHHH
PLLEKVVESNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHH
VTKATVVDPEVGINLNEAGEEVFGTARRITVSKDETIIVDGAGSAEDVEARRGQIRREIA
HHHHEEECCCCCCCCCHHHHHHHCCHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHH
NTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAG
CCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCEEEC
GGSALVQIAETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALP
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCC
NGEGFNAATLEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAH
CCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHC
AGHHHH
CCCCCC
>Mature Secondary Structure
MELNKGISAAAEKTLEELKARATEVSDTKEIANVATVSSRDEVVGEIVAAAMEKVGKDGV
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCE
VTVEESQSIETALEVTEGISFDKGYLSPYFINDNDTQQAVLDNPAVLLVRNKISSLPDFL
EEEECCCHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHCCCEEEEEECHHHCCHHHH
PLLEKVVESNRPLLIIAEDVEGEPLQTLVVNSIRKTIKVVAVKSPYFGDRRKAFMDDLAI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHH
VTKATVVDPEVGINLNEAGEEVFGTARRITVSKDETIIVDGAGSAEDVEARRGQIRREIA
HHHHEEECCCCCCCCCHHHHHHHCCHHEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHH
NTDSTWDREKAEERLAKLSGGIAVIRVGAATETEVNDRKLRVEDAINAARAAAQEGVIAG
CCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCEEEC
GGSALVQIAETLKAYAEEFEGDQKVGVRALATALGKPAYWIASNAGLDGSVVVARTAALP
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCC
NGEGFNAATLEYGNLINDGVIDPVKVTHSAVVNATSVARMVLTTEASVVEKPAEEAADAH
CCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHC
AGHHHH
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA