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The map label for this gene is murB

Identifier: 62389251

GI number: 62389251

Start: 374834

End: 375841

Strand: Direct

Name: murB

Synonym: cg0423

Alternate gene names: 62389251

Gene position: 374834-375841 (Clockwise)

Preceding gene: 62389250

Following gene: 62389252

Centisome position: 11.42

GC content: 43.45

Gene sequence:

>1008_bases
TTGAATGATTTTAAGAAAGTCTCCGAAAGTCTTGAGACCGCATTGCGTAATGAGTTCGACTTTCGGTTCGCTACCGAAGT
CTCATTGAAGGAGATATCGCGTTGGAGGATCGGAGGTCCTGCAGCTGTATTTGCTGAGCCTAGTTCTATTAATGAGATCT
GTGCTCTTCTTGCATTCATGAAAAATCGTCCGGAACCAGTAGTAGTTGTTGGCGGTACTTCCAATATTCTTTTTGATTCA
GATGGCTTTGGTGGCTTAGTTATAAAGTTGGGTGAAAATTTTAGCAACTTTATAATTGAAGGCAGCCGTATTCGTGCTCA
AGCTGGTGCTTCGGTACCTCAACTAGTGCGTGCTGTTGCGACCGAGGGGCTGGAAGGAATAGTTCATGCGGGCGGAATAC
CTGGAACTGTAGGTGGCTTAGTTGTTATGAATGGCGGAACCCAGCGTCGTGGAATCGGTGAGCATGTCACTAAAGTATTA
GTAACAGATGCTGAAGGCAGTATCCGAGAACTGAACGCAAATGAATTGCAGTTTACGTATAGAAACTCCGTACTTAAGAA
CTCTGAAACTACTGTATTAGAAGTCGAACTTCTTCTGAAGCCAGGAAATGCTGGAGAATTGTTGGCCGAATTGGAAACGA
TTCTAGATCAACGTTCTCAAAAGTTTCCTGAGGATCTTCCAAACTGTGGATCGACATTCCTTTCAGATCCCGCTATGTAC
AGTATTGTTGGTCCTCCTGGTAAGGCCATAGAAGATGCAGGATTAAAGGGACTTAGACGCGGTTCTGCAGAAATTTCCAT
GCAACATGCGAATTTTATAGTCAATCATGGGGATGCATCTGATGATGACATCTTGTGGTTGATCTCTGCTGTTCGAAAGG
AAGTTTATAGCAGAACTGGTTTTGTAATGGATTGTGAAGTTTTATATCTGTCATATTCTGGTGATTTTCGCCCTGCTCAT
GAAGTGGCGGACGAGCAATGGCCCGATATAGATTTAGTAAGGAACTAA

Upstream 100 bases:

>100_bases
CGTGGGTACAACGAGTTGGATAAAAAACTTCGTTTACTTGGTGCGGATTTAACTATCAGAGAAGGCGAAGTTCCTTCACC
TTAAGAACGAAAGTTTTACA

Downstream 100 bases:

>100_bases
AATGCCAAAAGTAAGTGTGGTTACTGGTTTTTATAACCGCTGTGAGCATTTAGAACGAACCATTGAGTCTATTCTTAACC
AAACTTATAGCGATTTTGAA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase 1

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNDFKKVSESLETALRNEFDFRFATEVSLKEISRWRIGGPAAVFAEPSSINEICALLAFMKNRPEPVVVVGGTSNILFDS
DGFGGLVIKLGENFSNFIIEGSRIRAQAGASVPQLVRAVATEGLEGIVHAGGIPGTVGGLVVMNGGTQRRGIGEHVTKVL
VTDAEGSIRELNANELQFTYRNSVLKNSETTVLEVELLLKPGNAGELLAELETILDQRSQKFPEDLPNCGSTFLSDPAMY
SIVGPPGKAIEDAGLKGLRRGSAEISMQHANFIVNHGDASDDDILWLISAVRKEVYSRTGFVMDCEVLYLSYSGDFRPAH
EVADEQWPDIDLVRN

Sequences:

>Translated_335_residues
MNDFKKVSESLETALRNEFDFRFATEVSLKEISRWRIGGPAAVFAEPSSINEICALLAFMKNRPEPVVVVGGTSNILFDS
DGFGGLVIKLGENFSNFIIEGSRIRAQAGASVPQLVRAVATEGLEGIVHAGGIPGTVGGLVVMNGGTQRRGIGEHVTKVL
VTDAEGSIRELNANELQFTYRNSVLKNSETTVLEVELLLKPGNAGELLAELETILDQRSQKFPEDLPNCGSTFLSDPAMY
SIVGPPGKAIEDAGLKGLRRGSAEISMQHANFIVNHGDASDDDILWLISAVRKEVYSRTGFVMDCEVLYLSYSGDFRPAH
EVADEQWPDIDLVRN
>Mature_335_residues
MNDFKKVSESLETALRNEFDFRFATEVSLKEISRWRIGGPAAVFAEPSSINEICALLAFMKNRPEPVVVVGGTSNILFDS
DGFGGLVIKLGENFSNFIIEGSRIRAQAGASVPQLVRAVATEGLEGIVHAGGIPGTVGGLVVMNGGTQRRGIGEHVTKVL
VTDAEGSIRELNANELQFTYRNSVLKNSETTVLEVELLLKPGNAGELLAELETILDQRSQKFPEDLPNCGSTFLSDPAMY
SIVGPPGKAIEDAGLKGLRRGSAEISMQHANFIVNHGDASDDDILWLISAVRKEVYSRTGFVMDCEVLYLSYSGDFRPAH
EVADEQWPDIDLVRN

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB1_CORGL (Q8NTF4)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927149
- RefSeq:   NP_599604.1
- RefSeq:   YP_224653.1
- ProteinModelPortal:   Q8NTF4
- SMR:   Q8NTF4
- GeneID:   1021403
- GeneID:   3343172
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0423
- KEGG:   cgl:NCgl0346
- HOGENOM:   HBG686573
- OMA:   CSAIRVE
- ProtClustDB:   CLSK262195
- BioCyc:   CGLU196627:CG0423-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 36372; Mature: 36372

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 181-181 ACT_SITE 231-231 ACT_SITE 306-306

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFKKVSESLETALRNEFDFRFATEVSLKEISRWRIGGPAAVFAEPSSINEICALLAFM
CCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
KNRPEPVVVVGGTSNILFDSDGFGGLVIKLGENFSNFIIEGSRIRAQAGASVPQLVRAVA
HCCCCCEEEECCCCCEEEECCCCCEEEEEECCCCHHHEEECCEEEECCCCCHHHHHHHHH
TEGLEGIVHAGGIPGTVGGLVVMNGGTQRRGIGEHVTKVLVTDAEGSIRELNANELQFTY
HCCHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHEEEEECCCCCCEECCCCCEEEEE
RNSVLKNSETTVLEVELLLKPGNAGELLAELETILDQRSQKFPEDLPNCGSTFLSDPAMY
HHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHCCCCEE
SIVGPPGKAIEDAGLKGLRRGSAEISMQHANFIVNHGDASDDDILWLISAVRKEVYSRTG
EEECCCCCHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
FVMDCEVLYLSYSGDFRPAHEVADEQWPDIDLVRN
CEEEEEEEEEEECCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNDFKKVSESLETALRNEFDFRFATEVSLKEISRWRIGGPAAVFAEPSSINEICALLAFM
CCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
KNRPEPVVVVGGTSNILFDSDGFGGLVIKLGENFSNFIIEGSRIRAQAGASVPQLVRAVA
HCCCCCEEEECCCCCEEEECCCCCEEEEEECCCCHHHEEECCEEEECCCCCHHHHHHHHH
TEGLEGIVHAGGIPGTVGGLVVMNGGTQRRGIGEHVTKVLVTDAEGSIRELNANELQFTY
HCCHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHEEEEECCCCCCEECCCCCEEEEE
RNSVLKNSETTVLEVELLLKPGNAGELLAELETILDQRSQKFPEDLPNCGSTFLSDPAMY
HHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHCCCCEE
SIVGPPGKAIEDAGLKGLRRGSAEISMQHANFIVNHGDASDDDILWLISAVRKEVYSRTG
EEECCCCCHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
FVMDCEVLYLSYSGDFRPAHEVADEQWPDIDLVRN
CEEEEEEEEEEECCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626