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The map label for this gene is dxr

Identifier: 62185056

GI number: 62185056

Start: 492224

End: 493363

Strand: Direct

Name: dxr

Synonym: CAB427

Alternate gene names: 62185056

Gene position: 492224-493363 (Clockwise)

Preceding gene: 62185055

Following gene: 62185057

Centisome position: 43.01

GC content: 38.16

Gene sequence:

>1140_bases
TTGAAACATTTAGCTATTTTTGGATCCACGGGAAGTGTGGGACAGCAAGCTTTGGCAATCATTCGCTCGCTTCCTCATTT
ATTCAATGTGGTTGCTCTTGCTTCATACGGTAATAAGAGAGATCTATTTTTTGAACAAATTCGAGAGTTTTCTCCTTCTA
TAGTTTCTGTATACGATGAACAGCTATATTTTGAAATTCGCAAGGAGTTCCCTAAGGTTCAGGCATTTCTTTGTGAGGAA
GGATTGCTCGCTGCTGCTACAGCTAACGAAATAGACACGATTGTTGCTGCATCTTCGGGGATAGTCGCTTTACCTGCAAT
TATTGCCGCTATGAGGTCAGGGAAAACCCTAGCATTAGCAAATAAAGAAGTTTTAGTTTCTGCCGGAGAATTAATTAATG
GACTTGCTCAGCAGTATCAAACTAAGATTTTGCCAATAGATAGTGAGCATAATGCTTTATATCAATGTTTGGAAGGCAGA
GACACCTCGGAAGTAAGAAAGTTGTTTTTAACAGCTTCTGGAGGTCCTTTATTATACAAATCTAAAGAAGAATTAACTCG
TGTGACTATTCAGGATGTATTGAAGCATCCCATATGGAATATGGGAGCTAAGATTACCGTAGATTCTTCAACATTGGTAA
ATAAAGGCTTAGAAATAATCGAGGCGTATTGGTTATTTGGATTAGAACATGCAGAGATAGATGCTGTAATTCATCCTCAA
AGTTTAATTCATGGTATGGTAGAGTTTGAAGACGGAACGGTGCTTTCTGTGATGAATCCGCCGAGTATGCTTTTCCCCAT
ACAACACGTATTAACAACCCCGAAACGCTGTCCAGCACCTCATAAAGGAATGGATTTTTCTATCAAACAAATATTAGAAT
TTTTTCCTATAGATGAGGAGCGTTTCCCAAGCATTGCTTTGGCGAGACAAGTATTACAAGATAAAGGATCCTCAGGACCA
TTTTTTAACGCTGCTAACGAGATCTTAGTTCAAAGATTTTTGAAAAAAGAAATTGCTTGGTGCGATATTCTAGATAAGTT
AACACGACTTATGAAAAATCATAGAGTTTCTTCGTGCACCTCGTTAGATGATGTCTTTTCTGTTGATAAAGAAGCTCGAG
CTCTTGCTCAAGAGATATAA

Upstream 100 bases:

>100_bases
GCTGGCTTATAAAAAGTTTTATTCAGAAGATAGTAAGAATACAGAATTGACAACTCTCTAACCTAAGAGTTATGATTTTT
TAATTTGTTAAGGTTACTAT

Downstream 100 bases:

>100_bases
CCTGGTACGTATATGACAATAATATATTTCATTCTTGCAGCCCTTGCTTTGGGGGTTTTAGTATTGGTTCATGAATTGGG
TCATTTACTGGCAGCCAAGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKHLAIFGSTGSVGQQALAIIRSLPHLFNVVALASYGNKRDLFFEQIREFSPSIVSVYDEQLYFEIRKEFPKVQAFLCEE
GLLAAATANEIDTIVAASSGIVALPAIIAAMRSGKTLALANKEVLVSAGELINGLAQQYQTKILPIDSEHNALYQCLEGR
DTSEVRKLFLTASGGPLLYKSKEELTRVTIQDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLEHAEIDAVIHPQ
SLIHGMVEFEDGTVLSVMNPPSMLFPIQHVLTTPKRCPAPHKGMDFSIKQILEFFPIDEERFPSIALARQVLQDKGSSGP
FFNAANEILVQRFLKKEIAWCDILDKLTRLMKNHRVSSCTSLDDVFSVDKEARALAQEI

Sequences:

>Translated_379_residues
MKHLAIFGSTGSVGQQALAIIRSLPHLFNVVALASYGNKRDLFFEQIREFSPSIVSVYDEQLYFEIRKEFPKVQAFLCEE
GLLAAATANEIDTIVAASSGIVALPAIIAAMRSGKTLALANKEVLVSAGELINGLAQQYQTKILPIDSEHNALYQCLEGR
DTSEVRKLFLTASGGPLLYKSKEELTRVTIQDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLEHAEIDAVIHPQ
SLIHGMVEFEDGTVLSVMNPPSMLFPIQHVLTTPKRCPAPHKGMDFSIKQILEFFPIDEERFPSIALARQVLQDKGSSGP
FFNAANEILVQRFLKKEIAWCDILDKLTRLMKNHRVSSCTSLDDVFSVDKEARALAQEI
>Mature_379_residues
MKHLAIFGSTGSVGQQALAIIRSLPHLFNVVALASYGNKRDLFFEQIREFSPSIVSVYDEQLYFEIRKEFPKVQAFLCEE
GLLAAATANEIDTIVAASSGIVALPAIIAAMRSGKTLALANKEVLVSAGELINGLAQQYQTKILPIDSEHNALYQCLEGR
DTSEVRKLFLTASGGPLLYKSKEELTRVTIQDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLEHAEIDAVIHPQ
SLIHGMVEFEDGTVLSVMNPPSMLFPIQHVLTTPKRCPAPHKGMDFSIKQILEFFPIDEERFPSIALARQVLQDKGSSGP
FFNAANEILVQRFLKKEIAWCDILDKLTRLMKNHRVSSCTSLDDVFSVDKEARALAQEI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=36.2244897959184, Blast_Score=240, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CHLAB (Q5L651)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219841.1
- ProteinModelPortal:   Q5L651
- SMR:   Q5L651
- GeneID:   3337656
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB427
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q5L651
- ProtClustDB:   PRK05447
- BioCyc:   CABO218497:CAB427-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42069; Mature: 42069

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: BINDING 122-122 BINDING 149-149 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLAIFGSTGSVGQQALAIIRSLPHLFNVVALASYGNKRDLFFEQIREFSPSIVSVYDE
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHH
QLYFEIRKEFPKVQAFLCEEGLLAAATANEIDTIVAASSGIVALPAIIAAMRSGKTLALA
HHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEE
NKEVLVSAGELINGLAQQYQTKILPIDSEHNALYQCLEGRDTSEVRKLFLTASGGPLLYK
CHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHCCCCHHHHHHHHEECCCCCEEEC
SKEELTRVTIQDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLEHAEIDAVIHPQ
CHHHHHHHHHHHHHHCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHCEEECHH
SLIHGMVEFEDGTVLSVMNPPSMLFPIQHVLTTPKRCPAPHKGMDFSIKQILEFFPIDEE
HHHHHHHEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHH
RFPSIALARQVLQDKGSSGPFFNAANEILVQRFLKKEIAWCDILDKLTRLMKNHRVSSCT
HCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
SLDDVFSVDKEARALAQEI
CHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MKHLAIFGSTGSVGQQALAIIRSLPHLFNVVALASYGNKRDLFFEQIREFSPSIVSVYDE
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHH
QLYFEIRKEFPKVQAFLCEEGLLAAATANEIDTIVAASSGIVALPAIIAAMRSGKTLALA
HHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEE
NKEVLVSAGELINGLAQQYQTKILPIDSEHNALYQCLEGRDTSEVRKLFLTASGGPLLYK
CHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHCCCCHHHHHHHHEECCCCCEEEC
SKEELTRVTIQDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLEHAEIDAVIHPQ
CHHHHHHHHHHHHHHCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHCEEECHH
SLIHGMVEFEDGTVLSVMNPPSMLFPIQHVLTTPKRCPAPHKGMDFSIKQILEFFPIDEE
HHHHHHHEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHH
RFPSIALARQVLQDKGSSGPFFNAANEILVQRFLKKEIAWCDILDKLTRLMKNHRVSSCT
HCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
SLDDVFSVDKEARALAQEI
CHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA