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The map label for this gene is gnd [H]

Identifier: 62185047

GI number: 62185047

Start: 480220

End: 481674

Strand: Direct

Name: gnd [H]

Synonym: CAB418

Alternate gene names: 62185047

Gene position: 480220-481674 (Clockwise)

Preceding gene: 62185046

Following gene: 62185049

Centisome position: 41.96

GC content: 41.1

Gene sequence:

>1455_bases
TTGGTGGCAGATAAAGCTGGTGCGGATATTGGGCTAATTGGTTTAGCTGTAATGGGGAAAAATCTGGTGTTGAATATGAT
CGACCATGGTTTTTCTGTGTCTGTCTATAATCGGAGTCCAGAGAAAACTCGAGAGTTTCTTCAAGAACATTCTCAAAGCC
CCGAACTTCAAGGACATGAAACATTAGAATCTTTTGTGCGTTCTTTAAAACGTCCTAGAAAGATCATGCTGATGATCAAA
GCAGGAACTCCTGTGGATCAAAGTATTGATTCGCTATTACCTTATCTTGAAGCTGGTGATATTATTATCGATGGGGGGAA
TAGCTATTATAAAGATTCAGAAAGACGGTGCCGTGATCTTAAGGAAAAAGGCATATTATTCATAGGTATGGGTATCTCTG
GAGGAGAAGAGGGCGCTCGTCATGGACCTTCTATTATGCCAGGAGGTAATAGTGATGCTTGGCCGGCAATAGCCCCTATC
TTCCAAAGTATTTCTGCTAAGGTTAATGGGAACCCCTGCTGCTGTTGGGTTGGCCCCGGAGGCGCAGGACATTATGTAAA
AACTGTACATAATGGCATAGAATATGGAGACATACAGTTAATTTGTGAGGCTTATGGCTTATTGAGAGCACGTTTAGATC
TATCTCCTGAAGCTGTATCCGTGATTTTTGCTGAATGGAACACACGTGAATTAGAAAGTTACTTGATGAGAATTTCTGTA
GAAGTTCTCTCTTTAAAAGATTCCAATGGCTTCCCAGTTATTGATACCATTTTAGATGTTGCTGGACAAAAAGGCACAGG
GCGTTGGACTGCCATTGACGCTATCGATTCGGGAGTGCCCCTTTCGCTAATTATTGAATCTGTATTAGCACGCTTCCTCT
CTTCTTGGAAAACTATTCGTGAGCGCGCTTCTCAAGAACTTCCGGGTGTTCCTATCGTTTTTGAAAAACCTAGAGACCCT
CATCTTTTTATTGAAGATGTGTTCCAAGCGCTATACGCTTCGAAAATTATCAGTTATGCTCAAGGATTCATGTTATTGAA
ACAAGCATCTGAAGAGCATCAATGGAATTTAAATTTTGGAGAGTTAGCCTTATTATGGAGAGGCGGATGCATTATCCAAA
GTGTTTTCCTAGATGCTATCCATAAAGGTTTCGAAAATGAGCCGGAAGCACCTTCGTTAATTTTACAAAGCTATTTCAAG
ACTGTATTACAACATTCCGAGCCCGGTTGGCGAAGAACAGTTGCCTATGGTGTGGGTTCAGGATATCCCATGCCTTGTTT
AGCAGCTGCATTAACATTTTATGATGGTTACCGAACAAAAGACTCTCCAATAGCTTTAGCTCAAGGATTAAGAGACTATT
TCGGAGCTCATACTTATGAACGTAAGGATAGACCTCGAGGGGAGTTCTATCATACAGATTGGATAGGGTCAAAAACAACA
ACTCTCGTAAAATAA

Upstream 100 bases:

>100_bases
GTTTTTGAAGAAACTCAGGTGTGTTTCGATCAATATGTTTTATTAGCACAGGGAAAGAAGAAAAAACTCGTTTTGCGTCT
AATTTAAGTGTGGAGGAGGA

Downstream 100 bases:

>100_bases
TTTGAGAAAAAGCGAGAGGGACTTCAGTGTGCGTTTTGCGCGACTCTCTTGCTATCTTTAGGATAACTTATAACGCCCCT
GTGTGTTGGCCTATGCTAAG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MVADKAGADIGLIGLAVMGKNLVLNMIDHGFSVSVYNRSPEKTREFLQEHSQSPELQGHETLESFVRSLKRPRKIMLMIK
AGTPVDQSIDSLLPYLEAGDIIIDGGNSYYKDSERRCRDLKEKGILFIGMGISGGEEGARHGPSIMPGGNSDAWPAIAPI
FQSISAKVNGNPCCCWVGPGGAGHYVKTVHNGIEYGDIQLICEAYGLLRARLDLSPEAVSVIFAEWNTRELESYLMRISV
EVLSLKDSNGFPVIDTILDVAGQKGTGRWTAIDAIDSGVPLSLIIESVLARFLSSWKTIRERASQELPGVPIVFEKPRDP
HLFIEDVFQALYASKIISYAQGFMLLKQASEEHQWNLNFGELALLWRGGCIIQSVFLDAIHKGFENEPEAPSLILQSYFK
TVLQHSEPGWRRTVAYGVGSGYPMPCLAAALTFYDGYRTKDSPIALAQGLRDYFGAHTYERKDRPRGEFYHTDWIGSKTT
TLVK

Sequences:

>Translated_484_residues
MVADKAGADIGLIGLAVMGKNLVLNMIDHGFSVSVYNRSPEKTREFLQEHSQSPELQGHETLESFVRSLKRPRKIMLMIK
AGTPVDQSIDSLLPYLEAGDIIIDGGNSYYKDSERRCRDLKEKGILFIGMGISGGEEGARHGPSIMPGGNSDAWPAIAPI
FQSISAKVNGNPCCCWVGPGGAGHYVKTVHNGIEYGDIQLICEAYGLLRARLDLSPEAVSVIFAEWNTRELESYLMRISV
EVLSLKDSNGFPVIDTILDVAGQKGTGRWTAIDAIDSGVPLSLIIESVLARFLSSWKTIRERASQELPGVPIVFEKPRDP
HLFIEDVFQALYASKIISYAQGFMLLKQASEEHQWNLNFGELALLWRGGCIIQSVFLDAIHKGFENEPEAPSLILQSYFK
TVLQHSEPGWRRTVAYGVGSGYPMPCLAAALTFYDGYRTKDSPIALAQGLRDYFGAHTYERKDRPRGEFYHTDWIGSKTT
TLVK
>Mature_484_residues
MVADKAGADIGLIGLAVMGKNLVLNMIDHGFSVSVYNRSPEKTREFLQEHSQSPELQGHETLESFVRSLKRPRKIMLMIK
AGTPVDQSIDSLLPYLEAGDIIIDGGNSYYKDSERRCRDLKEKGILFIGMGISGGEEGARHGPSIMPGGNSDAWPAIAPI
FQSISAKVNGNPCCCWVGPGGAGHYVKTVHNGIEYGDIQLICEAYGLLRARLDLSPEAVSVIFAEWNTRELESYLMRISV
EVLSLKDSNGFPVIDTILDVAGQKGTGRWTAIDAIDSGVPLSLIIESVLARFLSSWKTIRERASQELPGVPIVFEKPRDP
HLFIEDVFQALYASKIISYAQGFMLLKQASEEHQWNLNFGELALLWRGGCIIQSVFLDAIHKGFENEPEAPSLILQSYFK
TVLQHSEPGWRRTVAYGVGSGYPMPCLAAALTFYDGYRTKDSPIALAQGLRDYFGAHTYERKDRPRGEFYHTDWIGSKTT
TLVK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=477, Percent_Identity=55.1362683438155, Blast_Score=529, Evalue=1e-150,
Organism=Escherichia coli, GI1788341, Length=467, Percent_Identity=49.678800856531, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=51.1627906976744, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6321695, Length=478, Percent_Identity=50.836820083682, Blast_Score=518, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6321977, Length=475, Percent_Identity=52, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=52.5531914893617, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53567; Mature: 53567

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADKAGADIGLIGLAVMGKNLVLNMIDHGFSVSVYNRSPEKTREFLQEHSQSPELQGHE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHH
TLESFVRSLKRPRKIMLMIKAGTPVDQSIDSLLPYLEAGDIIIDGGNSYYKDSERRCRDL
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHH
KEKGILFIGMGISGGEEGARHGPSIMPGGNSDAWPAIAPIFQSISAKVNGNPCCCWVGPG
HHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCC
GAGHYVKTVHNGIEYGDIQLICEAYGLLRARLDLSPEAVSVIFAEWNTRELESYLMRISV
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCHHHHHHHHHHHHH
EVLSLKDSNGFPVIDTILDVAGQKGTGRWTAIDAIDSGVPLSLIIESVLARFLSSWKTIR
EEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ERASQELPGVPIVFEKPRDPHLFIEDVFQALYASKIISYAQGFMLLKQASEEHQWNLNFG
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ELALLWRGGCIIQSVFLDAIHKGFENEPEAPSLILQSYFKTVLQHSEPGWRRTVAYGVGS
HEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEECCC
GYPMPCLAAALTFYDGYRTKDSPIALAQGLRDYFGAHTYERKDRPRGEFYHTDWIGSKTT
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCC
TLVK
EECC
>Mature Secondary Structure
MVADKAGADIGLIGLAVMGKNLVLNMIDHGFSVSVYNRSPEKTREFLQEHSQSPELQGHE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHH
TLESFVRSLKRPRKIMLMIKAGTPVDQSIDSLLPYLEAGDIIIDGGNSYYKDSERRCRDL
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHH
KEKGILFIGMGISGGEEGARHGPSIMPGGNSDAWPAIAPIFQSISAKVNGNPCCCWVGPG
HHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCC
GAGHYVKTVHNGIEYGDIQLICEAYGLLRARLDLSPEAVSVIFAEWNTRELESYLMRISV
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCHHHHHHHHHHHHH
EVLSLKDSNGFPVIDTILDVAGQKGTGRWTAIDAIDSGVPLSLIIESVLARFLSSWKTIR
EEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ERASQELPGVPIVFEKPRDPHLFIEDVFQALYASKIISYAQGFMLLKQASEEHQWNLNFG
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ELALLWRGGCIIQSVFLDAIHKGFENEPEAPSLILQSYFKTVLQHSEPGWRRTVAYGVGS
HEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEECCC
GYPMPCLAAALTFYDGYRTKDSPIALAQGLRDYFGAHTYERKDRPRGEFYHTDWIGSKTT
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCC
TLVK
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]