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The map label for this gene is ftsI [H]

Identifier: 62184994

GI number: 62184994

Start: 416667

End: 418616

Strand: Direct

Name: ftsI [H]

Synonym: CAB362

Alternate gene names: 62184994

Gene position: 416667-418616 (Clockwise)

Preceding gene: 62184993

Following gene: 62184995

Centisome position: 36.41

GC content: 41.79

Gene sequence:

>1950_bases
ATGAATCACCGTAAATGCTTAACCATGATTACCTATGGAGTTCTGCTCTCCTATTCTTTCCTGATCATACGGTATTATAA
AATTCAGATTTGTGAGGAGAAACGTTGGGCAGCAGAAGCTTTAGGACAACATGAATTTCGAGTAAAGGACCCTTTTCGTA
GGGGGACGTTTTTTTCTCAGATGAATTTACGTAAGGGAGATTCAGAGCAACGACAAGCTCTGGCCGTGGACATTACGAAA
TTTCATCTTTGTTTAGATGCTGTAGCTGTTCCTGAAGAACACCGTGATGTGATTGCTAAGAAAGTTTTTAGTCTCATTGG
AGAAGGTGATTATGACAAACTCCGTGCGGAGTTTGATAAAAAATCTCGCTATCGAAAGTTATTTCTTTGGTTAGATCGTG
CGGATCATGACCGCATCCTATCTTGGTGGCGGGGGTACGCAGCAAAATCTAAAATACCCTCGAATGCTTTGTTTTTCATG
ACCGACTATCAAAGATCTTATCCCTTTGGCAAACTTTTAGGCCAAGTTCTACATACTCTGAGAGAAGTCAAGGATGAGAA
AACAGGCAAAGCTTTCCCTACAGGAGGTTTAGAAGCCTATTTTAACCACGTCCTTGAAGGAGAGCCAGGAGAACGGAAAT
TCCTACGTTCTCCTTTAAATCGTTTAGATCTAGATAAAGTCACAAAGATTCCTAGGGATGGTTCGGATATTTATCTCACA
GTCAATCCCTGTATACAGACTATAGCGGAAGAGGAATTAGAAAAAGGGGTAAAGGAAGCCAAAGCTAAAGGTGGGCGTCT
AATTTTAATGAATGCTTATACAGGCGAGATTCTTGCTTTAGCACAGTATCCTTTCTTTAATCCTTCGGAATACAAGGAAT
TTTTCAATGATAAGGAAAAAATAGAGCACACAAAAGTAACATCAGTCAGTGATGTGTTTGAACCCGGCTCTATCATGAAA
CCTCTGACTCTGGCTATAGCGTTGCTGGCCAACGAAGAGATGGTGAAAAGATCAGGAAAGCCCTTATTTGATCCTAATGA
ACCTATAGATGTAACCCGCAGGATTTTCCCAGGAAGAAAGCAATTTCCGCTTAAGGATATCTCATCGAATCGGCGTTTAA
ATATGTACATGGCGATTCAAAAGTCTTCGAACGTTTATGTAGCGCAACTTGCTGATCTTATAGTGCAACATCTAGGGAAC
CACTGGTATGAAGACAAGTTATTGTTATTAGGATTTGGTAAAAAGACGGGGATAGAATTGCCAGGGGAAGCGTCAGGATT
GGTACCTTCACCTAAACGTTTTCATATTAATGGGGTTCCTGAATGGTCTTTATCTACGCCTTATTCTCTTGCTATGGGGT
ATAATATCTTGGCTACGGGAGTGCAGATGGTTAAAGCCTATGCCATTCTTGCCAACGGTGGTTATGATGTGCGCCCTACC
TTGATAAAAAAAATAGTCACTACTTCTGGAAAAGAGTACGTGTTGCATCCTCAAGTTCGTGGAGAAAGAATTCTTTCTCA
GGACATTGTGGATGAGGTATTGAAAGCTACGCGTTTTACTACCTATCCTGGAGGAACGGGATTTCGGGCTGCGCCTAAAA
AGCATTCCAGTGCAGGGAAAACAGGAACAACAGAAAAGCTAGTTCATGGAAAGTATGATAAGCATCGGCATATTTCTTCA
TTTATAGGTATCACGCCGATATACCCTTCGGCAGGGGGGAGTGTTCCTTTGGTCATGCTTGTCTCTATAGATGATCCTGA
TCATTGTGTTCGCGAGGATGGAACAAAGAACTATATGGGAGGCCGATGTGCCGCCCCTGTATTTGGCAGAGTTGCGGATC
GTGTTTTATCTTATCTAGGAGTTCCCGAAGATAAAGAAAAATACAGTTATCAGAGTGAGGTGGCTGCTATGAAAGCTTTG
TATGAGGAATGGAATCGTTCGGGGAAATAA

Upstream 100 bases:

>100_bases
GATAAAATAGAGAGTCCAGAGCATCTCATGCATATAGTTAGCCTTCCTGAATACCAATATCTCCAATATCCTACAGAAGA
TAGTGTTTGTGTTGTAACTT

Downstream 100 bases:

>100_bases
TTTTTATATTATGTCTCCGTAGTAGCGGATGGGGCATTGGGCAAATTCCGGTTGTTTCTGAGAAAATCGCCAAAGTAAGA
AGATGATGGTAAAAATGATT

Product: penicillin-binding protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MNHRKCLTMITYGVLLSYSFLIIRYYKIQICEEKRWAAEALGQHEFRVKDPFRRGTFFSQMNLRKGDSEQRQALAVDITK
FHLCLDAVAVPEEHRDVIAKKVFSLIGEGDYDKLRAEFDKKSRYRKLFLWLDRADHDRILSWWRGYAAKSKIPSNALFFM
TDYQRSYPFGKLLGQVLHTLREVKDEKTGKAFPTGGLEAYFNHVLEGEPGERKFLRSPLNRLDLDKVTKIPRDGSDIYLT
VNPCIQTIAEEELEKGVKEAKAKGGRLILMNAYTGEILALAQYPFFNPSEYKEFFNDKEKIEHTKVTSVSDVFEPGSIMK
PLTLAIALLANEEMVKRSGKPLFDPNEPIDVTRRIFPGRKQFPLKDISSNRRLNMYMAIQKSSNVYVAQLADLIVQHLGN
HWYEDKLLLLGFGKKTGIELPGEASGLVPSPKRFHINGVPEWSLSTPYSLAMGYNILATGVQMVKAYAILANGGYDVRPT
LIKKIVTTSGKEYVLHPQVRGERILSQDIVDEVLKATRFTTYPGGTGFRAAPKKHSSAGKTGTTEKLVHGKYDKHRHISS
FIGITPIYPSAGGSVPLVMLVSIDDPDHCVREDGTKNYMGGRCAAPVFGRVADRVLSYLGVPEDKEKYSYQSEVAAMKAL
YEEWNRSGK

Sequences:

>Translated_649_residues
MNHRKCLTMITYGVLLSYSFLIIRYYKIQICEEKRWAAEALGQHEFRVKDPFRRGTFFSQMNLRKGDSEQRQALAVDITK
FHLCLDAVAVPEEHRDVIAKKVFSLIGEGDYDKLRAEFDKKSRYRKLFLWLDRADHDRILSWWRGYAAKSKIPSNALFFM
TDYQRSYPFGKLLGQVLHTLREVKDEKTGKAFPTGGLEAYFNHVLEGEPGERKFLRSPLNRLDLDKVTKIPRDGSDIYLT
VNPCIQTIAEEELEKGVKEAKAKGGRLILMNAYTGEILALAQYPFFNPSEYKEFFNDKEKIEHTKVTSVSDVFEPGSIMK
PLTLAIALLANEEMVKRSGKPLFDPNEPIDVTRRIFPGRKQFPLKDISSNRRLNMYMAIQKSSNVYVAQLADLIVQHLGN
HWYEDKLLLLGFGKKTGIELPGEASGLVPSPKRFHINGVPEWSLSTPYSLAMGYNILATGVQMVKAYAILANGGYDVRPT
LIKKIVTTSGKEYVLHPQVRGERILSQDIVDEVLKATRFTTYPGGTGFRAAPKKHSSAGKTGTTEKLVHGKYDKHRHISS
FIGITPIYPSAGGSVPLVMLVSIDDPDHCVREDGTKNYMGGRCAAPVFGRVADRVLSYLGVPEDKEKYSYQSEVAAMKAL
YEEWNRSGK
>Mature_649_residues
MNHRKCLTMITYGVLLSYSFLIIRYYKIQICEEKRWAAEALGQHEFRVKDPFRRGTFFSQMNLRKGDSEQRQALAVDITK
FHLCLDAVAVPEEHRDVIAKKVFSLIGEGDYDKLRAEFDKKSRYRKLFLWLDRADHDRILSWWRGYAAKSKIPSNALFFM
TDYQRSYPFGKLLGQVLHTLREVKDEKTGKAFPTGGLEAYFNHVLEGEPGERKFLRSPLNRLDLDKVTKIPRDGSDIYLT
VNPCIQTIAEEELEKGVKEAKAKGGRLILMNAYTGEILALAQYPFFNPSEYKEFFNDKEKIEHTKVTSVSDVFEPGSIMK
PLTLAIALLANEEMVKRSGKPLFDPNEPIDVTRRIFPGRKQFPLKDISSNRRLNMYMAIQKSSNVYVAQLADLIVQHLGN
HWYEDKLLLLGFGKKTGIELPGEASGLVPSPKRFHINGVPEWSLSTPYSLAMGYNILATGVQMVKAYAILANGGYDVRPT
LIKKIVTTSGKEYVLHPQVRGERILSQDIVDEVLKATRFTTYPGGTGFRAAPKKHSSAGKTGTTEKLVHGKYDKHRHISS
FIGITPIYPSAGGSVPLVMLVSIDDPDHCVREDGTKNYMGGRCAAPVFGRVADRVLSYLGVPEDKEKYSYQSEVAAMKAL
YEEWNRSGK

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=517, Percent_Identity=28.4332688588008, Blast_Score=155, Evalue=9e-39,
Organism=Escherichia coli, GI1786854, Length=420, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 73477; Mature: 73477

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHRKCLTMITYGVLLSYSFLIIRYYKIQICEEKRWAAEALGQHEFRVKDPFRRGTFFSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCEECCCHHHCCHHHH
MNLRKGDSEQRQALAVDITKFHLCLDAVAVPEEHRDVIAKKVFSLIGEGDYDKLRAEFDK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KSRYRKLFLWLDRADHDRILSWWRGYAAKSKIPSNALFFMTDYQRSYPFGKLLGQVLHTL
HHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
REVKDEKTGKAFPTGGLEAYFNHVLEGEPGERKFLRSPLNRLDLDKVTKIPRDGSDIYLT
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHCHHHHCCHHHHHCCCCCCCEEEEE
VNPCIQTIAEEELEKGVKEAKAKGGRLILMNAYTGEILALAQYPFFNPSEYKEFFNDKEK
EHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHCHHHH
IEHTKVTSVSDVFEPGSIMKPLTLAIALLANEEMVKRSGKPLFDPNEPIDVTRRIFPGRK
HHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
QFPLKDISSNRRLNMYMAIQKSSNVYVAQLADLIVQHLGNHWYEDKLLLLGFGKKTGIEL
CCCCHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PGEASGLVPSPKRFHINGVPEWSLSTPYSLAMGYNILATGVQMVKAYAILANGGYDVRPT
CCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHEECCCCCCCHH
LIKKIVTTSGKEYVLHPQVRGERILSQDIVDEVLKATRFTTYPGGTGFRAAPKKHSSAGK
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCCCCCCCC
TGTTEKLVHGKYDKHRHISSFIGITPIYPSAGGSVPLVMLVSIDDPDHCVREDGTKNYMG
CCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHCCCCCCCCC
GRCAAPVFGRVADRVLSYLGVPEDKEKYSYQSEVAAMKALYEEWNRSGK
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNHRKCLTMITYGVLLSYSFLIIRYYKIQICEEKRWAAEALGQHEFRVKDPFRRGTFFSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCEECCCHHHCCHHHH
MNLRKGDSEQRQALAVDITKFHLCLDAVAVPEEHRDVIAKKVFSLIGEGDYDKLRAEFDK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KSRYRKLFLWLDRADHDRILSWWRGYAAKSKIPSNALFFMTDYQRSYPFGKLLGQVLHTL
HHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
REVKDEKTGKAFPTGGLEAYFNHVLEGEPGERKFLRSPLNRLDLDKVTKIPRDGSDIYLT
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHCHHHHCCHHHHHCCCCCCCEEEEE
VNPCIQTIAEEELEKGVKEAKAKGGRLILMNAYTGEILALAQYPFFNPSEYKEFFNDKEK
EHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHCHHHH
IEHTKVTSVSDVFEPGSIMKPLTLAIALLANEEMVKRSGKPLFDPNEPIDVTRRIFPGRK
HHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
QFPLKDISSNRRLNMYMAIQKSSNVYVAQLADLIVQHLGNHWYEDKLLLLGFGKKTGIEL
CCCCHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PGEASGLVPSPKRFHINGVPEWSLSTPYSLAMGYNILATGVQMVKAYAILANGGYDVRPT
CCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHEECCCCCCCHH
LIKKIVTTSGKEYVLHPQVRGERILSQDIVDEVLKATRFTTYPGGTGFRAAPKKHSSAGK
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCCCCCCCC
TGTTEKLVHGKYDKHRHISSFIGITPIYPSAGGSVPLVMLVSIDDPDHCVREDGTKNYMG
CCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHCCCCCCCCC
GRCAAPVFGRVADRVLSYLGVPEDKEKYSYQSEVAAMKALYEEWNRSGK
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]