Click here to switch to the map view.

The map label for this gene is manP [H]

Identifier: 62184970

GI number: 62184970

Start: 392562

End: 393038

Strand: Direct

Name: manP [H]

Synonym: CAB339

Alternate gene names: 62184970

Gene position: 392562-393038 (Clockwise)

Preceding gene: 62184969

Following gene: 62184971

Centisome position: 34.3

GC content: 39.62

Gene sequence:

>477_bases
ATGCCTTTCTATTGCGAGAATCAATCTGATTTTTCCTTGTTTTCTCTTTTATCTCCTAACTTGATTATGTTTTTGAATAA
AACCTCACGAGAGGAGATTCTCCAAGATCTTACGGACCTTGCTAGTACTGCCGGTTTACTTGAGAATAAAGAAGAATTTT
TTCAAGCACTGGTAACTCGTGAAAATATTATGTCTACCGGTATTGGTATGGGCGTGGCAATTCCTCACGGGAAATTGCCT
AGTTGTTCTGACTTTTTTATCGCTATCGGTATCCACCCTCAAGGAATTCTCTGGGATGCGATAGATGGGGCTTTAGTGCG
TTTGGTCTTTCTGATAGGGGGGCCCGATCATGCTCAAGCTGAGTATCTCAAATTGTTATCTATATTGACTCTTTCGCTTA
GAGATGAATCTCGACGTCAAAAGTTGCTTCAAGTGACAACTATTGAAGAAGTTATGAATGTGTTTTTAGGAATGTAG

Upstream 100 bases:

>100_bases
CCCGTAGTCCAGGCAAAGTTTATCGCCGTGGATCAAGAAGAAGGACTAACAACAACGTCTCGGGGAAGTAGAGGTTTTGG
GCATACCGGAGAGAAGTGAC

Downstream 100 bases:

>100_bases
TGTTATGGATTTGAAATTAGAAGAGCTAGCTTCTTTGTTGGATATTTCTGAAAATACGGTCCGTCGGTGGCTAGATGAGG
GAGCTATCCCTAGTTACAGG

Product: PTS system, IIA component

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MPFYCENQSDFSLFSLLSPNLIMFLNKTSREEILQDLTDLASTAGLLENKEEFFQALVTRENIMSTGIGMGVAIPHGKLP
SCSDFFIAIGIHPQGILWDAIDGALVRLVFLIGGPDHAQAEYLKLLSILTLSLRDESRRQKLLQVTTIEEVMNVFLGM

Sequences:

>Translated_158_residues
MPFYCENQSDFSLFSLLSPNLIMFLNKTSREEILQDLTDLASTAGLLENKEEFFQALVTRENIMSTGIGMGVAIPHGKLP
SCSDFFIAIGIHPQGILWDAIDGALVRLVFLIGGPDHAQAEYLKLLSILTLSLRDESRRQKLLQVTTIEEVMNVFLGM
>Mature_157_residues
PFYCENQSDFSLFSLLSPNLIMFLNKTSREEILQDLTDLASTAGLLENKEEFFQALVTRENIMSTGIGMGVAIPHGKLPS
CSDFFIAIGIHPQGILWDAIDGALVRLVFLIGGPDHAQAEYLKLLSILTLSLRDESRRQKLLQVTTIEEVMNVFLGM

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1762

COG function: function code GT; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1786951, Length=130, Percent_Identity=30, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI2367327, Length=97, Percent_Identity=32.9896907216495, Blast_Score=64, Evalue=4e-12,
Organism=Escherichia coli, GI1789597, Length=106, Percent_Identity=36.7924528301887, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790027, Length=155, Percent_Identity=25.8064516129032, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 17606; Mature: 17475

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYCENQSDFSLFSLLSPNLIMFLNKTSREEILQDLTDLASTAGLLENKEEFFQALVTR
CCCCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ENIMSTGIGMGVAIPHGKLPSCSDFFIAIGIHPQGILWDAIDGALVRLVFLIGGPDHAQA
HHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
EYLKLLSILTLSLRDESRRQKLLQVTTIEEVMNVFLGM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFYCENQSDFSLFSLLSPNLIMFLNKTSREEILQDLTDLASTAGLLENKEEFFQALVTR
CCCCCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ENIMSTGIGMGVAIPHGKLPSCSDFFIAIGIHPQGILWDAIDGALVRLVFLIGGPDHAQA
HHHHHHCCCCCEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
EYLKLLSILTLSLRDESRRQKLLQVTTIEEVMNVFLGM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]