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The map label for this gene is dut

Identifier: 62184969

GI number: 62184969

Start: 392117

End: 392560

Strand: Direct

Name: dut

Synonym: CAB338A

Alternate gene names: 62184969

Gene position: 392117-392560 (Clockwise)

Preceding gene: 62184968

Following gene: 62184970

Centisome position: 34.26

GC content: 45.72

Gene sequence:

>444_bases
ATGACTATATTATGTGAATTAGAATCTGGAGTATCTCTTCCAGAATATGCTACCGAAGGGGCTTCAGGAGCAGACCTTCG
AGCGAATATTAAAGAGCCGATGGCTGTCTTGCCAGGACAACGTGTACTGGTTCCTACAGGAATAAAAATGCAGATCCCAC
AAGGCTATGAAGTTCAGGTGCGTCCACGCAGTGGGTTCGCACTGAAGCATGGGATTATGGTTGTGAATTCTCCGGGAACA
ATTGATGCAGATTATCGTGGTGAGGTTTGCATTATACTTGCAAATTTTGGAGAGAGTACTTTTATTATCGAACCCAAGAT
GCGCATTGCTCAAGCTGTAGTTGCTCCCGTAGTCCAGGCAAAGTTTATCGCCGTGGATCAAGAAGAAGGACTAACAACAA
CGTCTCGGGGAAGTAGAGGTTTTGGGCATACCGGAGAGAAGTGA

Upstream 100 bases:

>100_bases
TAGGGATTTATCCAAGACAATTAAAGAAATTTTTTTGTTGACAGATGACAGTGAATAAAACATCATACCCGCTACTCGTA
GTAACCACGGCGCTGTTCCT

Downstream 100 bases:

>100_bases
CATGCCTTTCTATTGCGAGAATCAATCTGATTTTTCCTTGTTTTCTCTTTTATCTCCTAACTTGATTATGTTTTTGAATA
AAACCTCACGAGAGGAGATT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MTILCELESGVSLPEYATEGASGADLRANIKEPMAVLPGQRVLVPTGIKMQIPQGYEVQVRPRSGFALKHGIMVVNSPGT
IDADYRGEVCIILANFGESTFIIEPKMRIAQAVVAPVVQAKFIAVDQEEGLTTTSRGSRGFGHTGEK

Sequences:

>Translated_147_residues
MTILCELESGVSLPEYATEGASGADLRANIKEPMAVLPGQRVLVPTGIKMQIPQGYEVQVRPRSGFALKHGIMVVNSPGT
IDADYRGEVCIILANFGESTFIIEPKMRIAQAVVAPVVQAKFIAVDQEEGLTTTSRGSRGFGHTGEK
>Mature_146_residues
TILCELESGVSLPEYATEGASGADLRANIKEPMAVLPGQRVLVPTGIKMQIPQGYEVQVRPRSGFALKHGIMVVNSPGTI
DADYRGEVCIILANFGESTFIIEPKMRIAQAVVAPVVQAKFIAVDQEEGLTTTSRGSRGFGHTGEK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=144, Percent_Identity=34.0277777777778, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI4503423, Length=144, Percent_Identity=34.0277777777778, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI70906441, Length=144, Percent_Identity=34.0277777777778, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1790071, Length=136, Percent_Identity=44.1176470588235, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71988561, Length=134, Percent_Identity=43.2835820895522, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319729, Length=136, Percent_Identity=32.3529411764706, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583610, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921126, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_CHLAB (Q5L6D8)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219754.1
- ProteinModelPortal:   Q5L6D8
- SMR:   Q5L6D8
- GeneID:   3337655
- GenomeReviews:   CR848038_GR
- HOGENOM:   HBG436079
- OMA:   LDLRACI
- PhylomeDB:   Q5L6D8
- ProtClustDB:   PRK00601
- BioCyc:   CABO218497:CAB338A-MONOMER
- BRENDA:   3.6.1.23
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15729; Mature: 15598

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: BINDING 76-76

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILCELESGVSLPEYATEGASGADLRANIKEPMAVLPGQRVLVPTGIKMQIPQGYEVQV
CEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCCEEEEECCCEEECCCCCEEEE
RPRSGFALKHGIMVVNSPGTIDADYRGEVCIILANFGESTFIIEPKMRIAQAVVAPVVQA
ECCCCCEEECCEEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHCE
KFIAVDQEEGLTTTSRGSRGFGHTGEK
EEEEEECCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TILCELESGVSLPEYATEGASGADLRANIKEPMAVLPGQRVLVPTGIKMQIPQGYEVQV
EEEEEECCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCCEEEEECCCEEECCCCCEEEE
RPRSGFALKHGIMVVNSPGTIDADYRGEVCIILANFGESTFIIEPKMRIAQAVVAPVVQA
ECCCCCEEECCEEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHCE
KFIAVDQEEGLTTTSRGSRGFGHTGEK
EEEEEECCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA