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The map label for this gene is obgE

Identifier: 62184838

GI number: 62184838

Start: 211784

End: 212791

Strand: Direct

Name: obgE

Synonym: CAB194

Alternate gene names: 62184838

Gene position: 211784-212791 (Clockwise)

Preceding gene: 62184837

Following gene: 62184842

Centisome position: 18.51

GC content: 43.25

Gene sequence:

>1008_bases
ATGTTTTTAGATCAGATTACCATAGAGTTGCGTGCTGGAAAAGGCGGTAACGGTGTTGTCGCTTGGAGAAAGGAAAAATA
TCTTCCCAAAGGTGGCCCCTATGGCGGTAACGGTGGTGTCGGTGGATCTATCATTATAGAGTCAGCTACACATGTGTACT
CTTTTGAATCCTATAGAAATATACGCTTTTTAAAAGCTGAAGACGGACGACCAGGAGCCACAAATAACCGCTCGGGAAAG
AACGGTAAAGACCTCGTCTTAATCGTTCCCGAAGGAACTTTACTCAGAGATGTAGAGACTAAAGAAATTCTCTATGACTT
TGCTAAAAGCGGAGAGCGTTTAGTCGTTTGTCGTGGAGGTAAAGGAGGTAAGGGGAATACGTTTTTCAAAACGTCTACAA
ACCGCGCTCCTACCAAAGCCACTCCCGGCAAGCCTGGAGAAATACGCCAGGTAGAGCTTGAGCTCAAGCTGATCGCTGAT
ATTGGCCTTGTGGGTTTCCCTAATGCAGGAAAATCTACATTATTCAACACTCTTGCAAGAACAGAAGTCAAGGTCGGGGC
TTATCCCTTCACTACACTGCAACCTGTATTGGGTCTTGTTCCTTGCCAGGAAAAATTGTACCAGAAACCCTGGATTATAG
CAGATATTCCCGGGATCATAGAAGGAGCTCACCAAAATCGTGGTTTAGGGCTGGATTTCTTAAGACATATTGAGCGTACC
AGATTATTGTTGTTTGTGATTGATATTTGTGGATGCGAGAGATCCTCCCCAGAAGAAGATCTACGTATTCTTATGGACGA
GCTTGTACATTATAGAGAAGATCTCGCAGACAAGAATCGGATTATCGCTTTAAACAAGATCGATGATCTTCTTCCCGATG
AAAGGCAAGAACGTCTAGAAAGTTTTCAAAAACTCTTTCCTTCTGAGACGTTTGTATTAGTATCCGGACTTACTGGAGAA
GGAGTCGATTTACTCAACAGTCTTTTCACAAATAAACTAGCCGTGTAA

Upstream 100 bases:

>100_bases
CAAAAACTAAGTTTGTCTAGCAAGCTCTATTTTTTGCTTATGCATAAAATGGGGCTTTTCTATTTTTAACAGCGTCTGCG
ATTTAGGGGATAAATACACC

Downstream 100 bases:

>100_bases
ACACCACCCATCAAGATCGCAATTGTTGGCCCTGCAGGGAAATCTACAGCATAGGCAAGGATAATCCCGGAAAATGAGCA
TAAGATGTTCAAGAGAACAG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MFLDQITIELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGVGGSIIIESATHVYSFESYRNIRFLKAEDGRPGATNNRSGK
NGKDLVLIVPEGTLLRDVETKEILYDFAKSGERLVVCRGGKGGKGNTFFKTSTNRAPTKATPGKPGEIRQVELELKLIAD
IGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLQPVLGLVPCQEKLYQKPWIIADIPGIIEGAHQNRGLGLDFLRHIERT
RLLLFVIDICGCERSSPEEDLRILMDELVHYREDLADKNRIIALNKIDDLLPDERQERLESFQKLFPSETFVLVSGLTGE
GVDLLNSLFTNKLAV

Sequences:

>Translated_335_residues
MFLDQITIELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGVGGSIIIESATHVYSFESYRNIRFLKAEDGRPGATNNRSGK
NGKDLVLIVPEGTLLRDVETKEILYDFAKSGERLVVCRGGKGGKGNTFFKTSTNRAPTKATPGKPGEIRQVELELKLIAD
IGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLQPVLGLVPCQEKLYQKPWIIADIPGIIEGAHQNRGLGLDFLRHIERT
RLLLFVIDICGCERSSPEEDLRILMDELVHYREDLADKNRIIALNKIDDLLPDERQERLESFQKLFPSETFVLVSGLTGE
GVDLLNSLFTNKLAV
>Mature_335_residues
MFLDQITIELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGVGGSIIIESATHVYSFESYRNIRFLKAEDGRPGATNNRSGK
NGKDLVLIVPEGTLLRDVETKEILYDFAKSGERLVVCRGGKGGKGNTFFKTSTNRAPTKATPGKPGEIRQVELELKLIAD
IGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLQPVLGLVPCQEKLYQKPWIIADIPGIIEGAHQNRGLGLDFLRHIERT
RLLLFVIDICGCERSSPEEDLRILMDELVHYREDLADKNRIIALNKIDDLLPDERQERLESFQKLFPSETFVLVSGLTGE
GVDLLNSLFTNKLAV

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=324, Percent_Identity=41.6666666666667, Blast_Score=177, Evalue=9e-45,
Organism=Homo sapiens, GI111955139, Length=282, Percent_Identity=38.6524822695035, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI111955063, Length=195, Percent_Identity=37.9487179487179, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI58761500, Length=131, Percent_Identity=35.1145038167939, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=331, Percent_Identity=44.4108761329305, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1787454, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=326, Percent_Identity=34.6625766871166, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17552324, Length=327, Percent_Identity=31.8042813455657, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321962, Length=186, Percent_Identity=41.3978494623656, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319281, Length=90, Percent_Identity=42.2222222222222, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20129375, Length=327, Percent_Identity=38.2262996941896, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24585318, Length=293, Percent_Identity=37.8839590443686, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=33.59375, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=33.59375, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=33.59375, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21356473, Length=90, Percent_Identity=38.8888888888889, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CHLAB (Q5L6R9)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219623.1
- HSSP:   P44681
- ProteinModelPortal:   Q5L6R9
- SMR:   Q5L6R9
- GeneID:   3337612
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB194
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- ProtClustDB:   PRK12299
- BioCyc:   CABO218497:CAB194-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36956; Mature: 36956

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLDQITIELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGVGGSIIIESATHVYSFESYRN
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHEEEHHCCCC
IRFLKAEDGRPGATNNRSGKNGKDLVLIVPEGTLLRDVETKEILYDFAKSGERLVVCRGG
EEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCEEEEEECC
KGGKGNTFFKTSTNRAPTKATPGKPGEIRQVELELKLIADIGLVGFPNAGKSTLFNTLAR
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEECCEEECCCCCHHHHHHHHHH
TEVKVGAYPFTTLQPVLGLVPCQEKLYQKPWIIADIPGIIEGAHQNRGLGLDFLRHIERT
HEEEECCCCCHHHHHHHCCCCCHHHHHCCCEEEEECCHHHHCCCCCCCCCHHHHHHHHHH
RLLLFVIDICGCERSSPEEDLRILMDELVHYREDLADKNRIIALNKIDDLLPDERQERLE
HHHHHHEEHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCHHHHHHH
SFQKLFPSETFVLVSGLTGEGVDLLNSLFTNKLAV
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLDQITIELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGVGGSIIIESATHVYSFESYRN
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCHHEEEHHCCCC
IRFLKAEDGRPGATNNRSGKNGKDLVLIVPEGTLLRDVETKEILYDFAKSGERLVVCRGG
EEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCEEEEEECC
KGGKGNTFFKTSTNRAPTKATPGKPGEIRQVELELKLIADIGLVGFPNAGKSTLFNTLAR
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEEECCEEECCCCCHHHHHHHHHH
TEVKVGAYPFTTLQPVLGLVPCQEKLYQKPWIIADIPGIIEGAHQNRGLGLDFLRHIERT
HEEEECCCCCHHHHHHHCCCCCHHHHHCCCEEEEECCHHHHCCCCCCCCCHHHHHHHHHH
RLLLFVIDICGCERSSPEEDLRILMDELVHYREDLADKNRIIALNKIDDLLPDERQERLE
HHHHHHEEHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCHHHHHHH
SFQKLFPSETFVLVSGLTGEGVDLLNSLFTNKLAV
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA