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The map label for this gene is lpxC [H]

Identifier: 62184732

GI number: 62184732

Start: 103810

End: 104667

Strand: Direct

Name: lpxC [H]

Synonym: CAB088

Alternate gene names: 62184732

Gene position: 103810-104667 (Clockwise)

Preceding gene: 62184731

Following gene: 62184733

Centisome position: 9.07

GC content: 41.72

Gene sequence:

>858_bases
TTGTCAGGTTTTTGCATGTTAGAACGAGCTCAAAGAACGTTAAGGCGCGAAGTACGTTATTCAGGTGTGGGAATTCACTT
TGGAAAGTCCGCGACTATAACTTTAGAACCTGCTAAAGAAAACACCGGAATAGTCTTTTGCCGTTCCGATCTTTTAGGGG
AACATATCCCCGCATTACTTCCTCATGTATGTAATACAGGCCGCAGTACTACCCTGTCTTCAGGAGATTCGATTATTGCT
ACTGTTGAACATCTCATGGCTGCTTTGCGTTCGAGTAATATTGATAATGTGATCGTCCGTTGTGATGAAGAAGAAATCCC
CATCGGGGATGGAAGTTCTCATGTTTTTATGCAGTTAATCCATGATGCTGGGGTTTGTACGCAGAATGATAAGGTCTCCA
TTGCTAGGCTATCACAGCCTGTCTACTATCAAGCGCAAGATACTTTTCTTGCCGCATTTCCTTGTGATGAGCTGAAGATT
TCTTACACTCTACATTATCCTCAAAGTCCTACCATAGGGACGCAGTACCGTTCTTTCGTTATAACGGAAGAATCTTTTCG
TAAGGAAATAGCTCCTTGTAGAACATTTGCTCTATACAATGAGCTATGTTTTTTAATGGAAAGAGGGTTGATTGGAGGCG
GATGTCTAGAAAATGCTGTAGTGTTTAAAGATGATGGTGTTATTAGTCTCGGCCAGCTACGGTTTCCAGATGAGCCCGTA
AGGCATAAAATTTTGGATTTAATAGGTGATCTATCTTTGGTAGGCAGACCTTTTGTTGCTCATATTGTGGCTGTGGGGTC
GGGACATTCTTCAAACATTGCTTTGGGTAGAAAGATTTTAGAAGTGTTACAACCCTAA

Upstream 100 bases:

>100_bases
CTATGATTTTGCTATCCTTGTTGTCTATAGGATGCATCGGATGTTATTTCGGATATCGCTTGCTTGCTAAAAAAGAAAAA
GGATAATATACGAACACTCT

Downstream 100 bases:

>100_bases
GAAACGAGTGCTAAATGAAAGAGTCGCCTGTAATTAAATTACGAGAATTATTAAACTTACTCCCGCATCGTTATCCTTTT
TTGCTTGTGGATAAGGTGTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSGFCMLERAQRTLRREVRYSGVGIHFGKSATITLEPAKENTGIVFCRSDLLGEHIPALLPHVCNTGRSTTLSSGDSIIA
TVEHLMAALRSSNIDNVIVRCDEEEIPIGDGSSHVFMQLIHDAGVCTQNDKVSIARLSQPVYYQAQDTFLAAFPCDELKI
SYTLHYPQSPTIGTQYRSFVITEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLENAVVFKDDGVISLGQLRFPDEPV
RHKILDLIGDLSLVGRPFVAHIVAVGSGHSSNIALGRKILEVLQP

Sequences:

>Translated_285_residues
MSGFCMLERAQRTLRREVRYSGVGIHFGKSATITLEPAKENTGIVFCRSDLLGEHIPALLPHVCNTGRSTTLSSGDSIIA
TVEHLMAALRSSNIDNVIVRCDEEEIPIGDGSSHVFMQLIHDAGVCTQNDKVSIARLSQPVYYQAQDTFLAAFPCDELKI
SYTLHYPQSPTIGTQYRSFVITEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLENAVVFKDDGVISLGQLRFPDEPV
RHKILDLIGDLSLVGRPFVAHIVAVGSGHSSNIALGRKILEVLQP
>Mature_284_residues
SGFCMLERAQRTLRREVRYSGVGIHFGKSATITLEPAKENTGIVFCRSDLLGEHIPALLPHVCNTGRSTTLSSGDSIIAT
VEHLMAALRSSNIDNVIVRCDEEEIPIGDGSSHVFMQLIHDAGVCTQNDKVSIARLSQPVYYQAQDTFLAAFPCDELKIS
YTLHYPQSPTIGTQYRSFVITEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLENAVVFKDDGVISLGQLRFPDEPVR
HKILDLIGDLSLVGRPFVAHIVAVGSGHSSNIALGRKILEVLQP

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=277, Percent_Identity=35.7400722021661, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 31335; Mature: 31204

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFCMLERAQRTLRREVRYSGVGIHFGKSATITLEPAKENTGIVFCRSDLLGEHIPALL
CCCCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCEEEECHHHHHHHHHHHH
PHVCNTGRSTTLSSGDSIIATVEHLMAALRSSNIDNVIVRCDEEEIPIGDGSSHVFMQLI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
HDAGVCTQNDKVSIARLSQPVYYQAQDTFLAAFPCDELKISYTLHYPQSPTIGTQYRSFV
HHCCCCCCCCCEEHEECCCCEEEEECCCEEEEECCCCEEEEEEEECCCCCCCCCCHHEEE
ITEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLENAVVFKDDGVISLGQLRFPDEPV
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEECCCEEEECCCCCCCHHH
RHKILDLIGDLSLVGRPFVAHIVAVGSGHSSNIALGRKILEVLQP
HHHHHHHHHHHHHHCCHHHHHEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SGFCMLERAQRTLRREVRYSGVGIHFGKSATITLEPAKENTGIVFCRSDLLGEHIPALL
CCCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCEEEECHHHHHHHHHHHH
PHVCNTGRSTTLSSGDSIIATVEHLMAALRSSNIDNVIVRCDEEEIPIGDGSSHVFMQLI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
HDAGVCTQNDKVSIARLSQPVYYQAQDTFLAAFPCDELKISYTLHYPQSPTIGTQYRSFV
HHCCCCCCCCCEEHEECCCCEEEEECCCEEEEECCCCEEEEEEEECCCCCCCCCCHHEEE
ITEESFRKEIAPCRTFALYNELCFLMERGLIGGGCLENAVVFKDDGVISLGQLRFPDEPV
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEECCCEEEECCCCCCCHHH
RHKILDLIGDLSLVGRPFVAHIVAVGSGHSSNIALGRKILEVLQP
HHHHHHHHHHHHHHCCHHHHHEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA