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The map label for this gene is pgk

Identifier: 62184709

GI number: 62184709

Start: 76004

End: 77215

Strand: Direct

Name: pgk

Synonym: CAB062

Alternate gene names: 62184709

Gene position: 76004-77215 (Clockwise)

Preceding gene: 62184708

Following gene: 62184710

Centisome position: 6.64

GC content: 44.14

Gene sequence:

>1212_bases
ATGGATAGATTGACAGTCAGGGAACTCTCCCCAGAAGAAAAAAAGGTTTTAGTCCGTGTAGATTTTAATGTTCCTATAAA
AGATGGGAAGATTCTTGATGATATCCGCATCCGTAGTGCGATGCCGACAATTCATTATCTATTACAAAAGCGCGCTGCTG
TAATTTTAATGAGTCATCTGGGTCGCCCTCAAGGAAAGGGTTTCGAAGAAAAATATTCTCTCCAGCCTGTTGTGGAAGTT
TTAGAGGGTTACCTAGGTCATCACGTGCCTTTAGCCCCCGATTGCGTAGGAGAAGTTGCTCGTCAGGCAGTAGCACAAAT
TTCTCCAGGACGCGTGTTGTTATTAGAAAATCTTCGTTTTCATCCAGGAGAAGAACATCCTGAAGAACATCCTGCTTTTG
CTGCAGAACTTTCCTCCTACGGAGATTTTTATGTGAATGATGCTTTTGGAACTTCACACAGAAAACATGCCTCCGTGTAC
ACGGTTCCTCAAGCTTTTCCAGGGCGATCTGCGGCAGGTCTTCTTATGGAAAAAGAACTCGAGTTTTTAGGACAGCACCT
GTTAATTTCTCCTAAGCGTCCCTTTACTGCGATTCTTGGCGGTTCTAAAGTATCTTCAAAAATCGGCGTTATCGAAGCCT
TACTCTCTCAAGTGGATAACCTACTTTTAGCAGGCGGCATGGGCTTTACTTTTTTAAAAGCATTAGGAAAATCCGTAGGG
AATTCCTTAGTTGAAGAATCTGGCATAGAACTCGCACGTCGGGTTTTACACATTGCACAACAGCGTAATGTACGTATCGT
TCTTCCTATAGATGTGAAGGTTGCCAAAGCCTGTACTCCCGCAGTGTCTTGGACGGAAGTCTCTATAGATCAAGGGATCC
CTCAAGATCTCGAAGGCCTAGATATAGGAACAAAAACTGTTCAAGAATTTTGTAAAATCATCGATGCCTCATCCACCATA
TTTTGGAATGGCCCTGTTGGTGTTTATGAAGTGCCTCCTTTTGATCAGGGGTCCATGGCTATCGCTAATTGTTTAGCACG
ACATCCTTCTGCCATTACAGTTGTGGGAGGTGGAGATGCTGCTGCTGTTGTTGCTTTGGCCGGATGCACAGCACAAGTCT
CACACGTGTCTACAGGTGGTGGTGCGTCTTTAGAATTCCTAGAGAAAGGTTTTTTACCAGGAACCGAAGTTCTGTCTCCA
TCACAAGAGTAA

Upstream 100 bases:

>100_bases
CTTCCAGCAGGAGCAATTCTCTCTATTCTATTTTTCTTTGCTTTAAGAGCGCTCTTCCAGTAAAAATAGGGAAATCATCT
TAGATAGTTTCTCAAGGTAT

Downstream 100 bases:

>100_bases
ACTTTTTTAAGCTCTTATTTTTCAGACACTTCAATAAAATGGCTTTTTAATAGCATAAAGCTGAATCCAGCTTTATGCTG
AAATCTTCATCAGCAATTCC

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MDRLTVRELSPEEKKVLVRVDFNVPIKDGKILDDIRIRSAMPTIHYLLQKRAAVILMSHLGRPQGKGFEEKYSLQPVVEV
LEGYLGHHVPLAPDCVGEVARQAVAQISPGRVLLLENLRFHPGEEHPEEHPAFAAELSSYGDFYVNDAFGTSHRKHASVY
TVPQAFPGRSAAGLLMEKELEFLGQHLLISPKRPFTAILGGSKVSSKIGVIEALLSQVDNLLLAGGMGFTFLKALGKSVG
NSLVEESGIELARRVLHIAQQRNVRIVLPIDVKVAKACTPAVSWTEVSIDQGIPQDLEGLDIGTKTVQEFCKIIDASSTI
FWNGPVGVYEVPPFDQGSMAIANCLARHPSAITVVGGGDAAAVVALAGCTAQVSHVSTGGGASLEFLEKGFLPGTEVLSP
SQE

Sequences:

>Translated_403_residues
MDRLTVRELSPEEKKVLVRVDFNVPIKDGKILDDIRIRSAMPTIHYLLQKRAAVILMSHLGRPQGKGFEEKYSLQPVVEV
LEGYLGHHVPLAPDCVGEVARQAVAQISPGRVLLLENLRFHPGEEHPEEHPAFAAELSSYGDFYVNDAFGTSHRKHASVY
TVPQAFPGRSAAGLLMEKELEFLGQHLLISPKRPFTAILGGSKVSSKIGVIEALLSQVDNLLLAGGMGFTFLKALGKSVG
NSLVEESGIELARRVLHIAQQRNVRIVLPIDVKVAKACTPAVSWTEVSIDQGIPQDLEGLDIGTKTVQEFCKIIDASSTI
FWNGPVGVYEVPPFDQGSMAIANCLARHPSAITVVGGGDAAAVVALAGCTAQVSHVSTGGGASLEFLEKGFLPGTEVLSP
SQE
>Mature_403_residues
MDRLTVRELSPEEKKVLVRVDFNVPIKDGKILDDIRIRSAMPTIHYLLQKRAAVILMSHLGRPQGKGFEEKYSLQPVVEV
LEGYLGHHVPLAPDCVGEVARQAVAQISPGRVLLLENLRFHPGEEHPEEHPAFAAELSSYGDFYVNDAFGTSHRKHASVY
TVPQAFPGRSAAGLLMEKELEFLGQHLLISPKRPFTAILGGSKVSSKIGVIEALLSQVDNLLLAGGMGFTFLKALGKSVG
NSLVEESGIELARRVLHIAQQRNVRIVLPIDVKVAKACTPAVSWTEVSIDQGIPQDLEGLDIGTKTVQEFCKIIDASSTI
FWNGPVGVYEVPPFDQGSMAIANCLARHPSAITVVGGGDAAAVVALAGCTAQVSHVSTGGGASLEFLEKGFLPGTEVLSP
SQE

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family

Homologues:

Organism=Homo sapiens, GI4505763, Length=417, Percent_Identity=42.2062350119904, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI31543397, Length=414, Percent_Identity=42.2705314009662, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1789294, Length=398, Percent_Identity=38.6934673366834, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17508823, Length=419, Percent_Identity=41.7661097852029, Blast_Score=320, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6319857, Length=418, Percent_Identity=42.1052631578947, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24581203, Length=415, Percent_Identity=44.3373493975904, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI17136394, Length=418, Percent_Identity=42.3444976076555, Blast_Score=305, Evalue=4e-83,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): PGK_CHLAB (Q5L748)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219494.1
- HSSP:   P36204
- ProteinModelPortal:   Q5L748
- SMR:   Q5L748
- GeneID:   3337662
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB062
- HOGENOM:   HBG453500
- OMA:   DCIGDEV
- PhylomeDB:   Q5L748
- ProtClustDB:   PRK00073
- BioCyc:   CABO218497:CAB062-MONOMER
- BRENDA:   2.7.2.3
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_00145
- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824
- Gene3D:   G3DSA:3.40.50.1270
- Gene3D:   G3DSA:3.40.50.1260
- PANTHER:   PTHR11406
- PIRSF:   PIRSF000724
- PRINTS:   PR00477

Pfam domain/function: PF00162 PGK; SSF53748 PGK

EC number: =2.7.2.3

Molecular weight: Translated: 43302; Mature: 43302

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: BINDING 36-36 BINDING 119-119 BINDING 154-154 BINDING 207-207 BINDING 299-299 BINDING 330-330

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLTVRELSPEEKKVLVRVDFNVPIKDGKILDDIRIRSAMPTIHYLLQKRAAVILMSHL
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRPQGKGFEEKYSLQPVVEVLEGYLGHHVPLAPDCVGEVARQAVAQISPGRVLLLENLRF
CCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
HPGEEHPEEHPAFAAELSSYGDFYVNDAFGTSHRKHASVYTVPQAFPGRSAAGLLMEKEL
CCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
EFLGQHLLISPKRPFTAILGGSKVSSKIGVIEALLSQVDNLLLAGGMGFTFLKALGKSVG
HHHCHHEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
NSLVEESGIELARRVLHIAQQRNVRIVLPIDVKVAKACTPAVSWTEVSIDQGIPQDLEGL
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCEEEEECCCCCCCCCCCC
DIGTKTVQEFCKIIDASSTIFWNGPVGVYEVPPFDQGSMAIANCLARHPSAITVVGGGDA
CCCHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCH
AAVVALAGCTAQVSHVSTGGGASLEFLEKGFLPGTEVLSPSQE
HHHHHHHCCHHHHHEECCCCCCHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MDRLTVRELSPEEKKVLVRVDFNVPIKDGKILDDIRIRSAMPTIHYLLQKRAAVILMSHL
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRPQGKGFEEKYSLQPVVEVLEGYLGHHVPLAPDCVGEVARQAVAQISPGRVLLLENLRF
CCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
HPGEEHPEEHPAFAAELSSYGDFYVNDAFGTSHRKHASVYTVPQAFPGRSAAGLLMEKEL
CCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
EFLGQHLLISPKRPFTAILGGSKVSSKIGVIEALLSQVDNLLLAGGMGFTFLKALGKSVG
HHHCHHEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
NSLVEESGIELARRVLHIAQQRNVRIVLPIDVKVAKACTPAVSWTEVSIDQGIPQDLEGL
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCEEEEECCCCCCCCCCCC
DIGTKTVQEFCKIIDASSTIFWNGPVGVYEVPPFDQGSMAIANCLARHPSAITVVGGGDA
CCCHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCH
AAVVALAGCTAQVSHVSTGGGASLEFLEKGFLPGTEVLSPSQE
HHHHHHHCCHHHHHEECCCCCCHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA