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The map label for this gene is gcvT [H]

Identifier: 59713883

GI number: 59713883

Start: 776488

End: 777606

Strand: Reverse

Name: gcvT [H]

Synonym: VF_A0700

Alternate gene names: 59713883

Gene position: 777606-776488 (Counterclockwise)

Preceding gene: 59713884

Following gene: 59713882

Centisome position: 58.45

GC content: 41.29

Gene sequence:

>1119_bases
ATGTCAGAACAATTACATAAAACGGCACTTTACGAAATTCATGTAGCAGCTGGCGCAAAGATGGTGCCATTTGCAGGATA
TGAAATGCCAGTGCAGTATCCACTTGGTGTAAAAAAAGAGCACCTTCATACTCGTAATGCCGCTGGTTTATTTGATGTAT
CGCACATGGGGCAACTTAGACTTAAAGGAAAAAATGCAGCTGCTGCATTAGAAGCTTTGGTTCCTGTAGATATTATCGAT
CTCCCTTCTCAGAAACAGCGATATGCATTTTTTACTAATGATAATGGCGGCATTATGGATGATTTGATGGTAGCCAACTT
TGGTGATCATCTGTTTGTTGTAGTAAATGCAGCGTGTAAAGAACAAGATATTGCGCACTTAGTAGCTAATTTACCTTCTG
ATGTTGAAATAGAAGTTATTGAAGATCGAGCTTTATTGGCTCTTCAAGGTCCACAAGCTGCCGACGTATTATCACGACTT
CAACCTTCTGTTTCTAATATGCTATTTATGGATACGGCAGTAGTAGAGATCAGTGGCATTGAATGTTATGTCAGCCGCTC
TGGTTATACTGGAGAGGATGGATATGAAATATCAGTACCAAATGATAAAGCAGCAGAATTAGCAGAGACCTTAACCTCAT
TTGAAGAAGTGGAATGGATAGGTTTAGGTGCTCGTGACTCATTACGCTTAGAATGTGGTTTGTGTCTGTATGGACATGAT
TTAGATACGACAACGACACCAGTAGAAGCTAGTCTTTTATGGGCAATAAGTAAAAACCGTCGTGCTGATGGTGAACGTGT
CGCTGGTTTCCCTGGTGCTGATGTTATTTTAAAGCAGATTGAAACAAAAGATGTAAATCGAAAACGTGTCGGTCTTGTTG
GACAAACTAAAGCGCCTGTGCGTGAAGGATGTAAGCTTTATGATGCGGATGATAATGAAATTGGCATTGTAACGAGTGGT
ACAGCGGGGCCAACAGCAGGAAAGCCTGTATCAATGGCATATGTACGAACCGATCTTGCGAGCCTTGGCACTGAAGTATT
TGCTGATGTAAGAGGAAAGAAACTTCCAATGACGGTTGAGAAGATGCCATTTGTTCCTCAGCGCTATTATCGCGGATAA

Upstream 100 bases:

>100_bases
AAGATGCTCAAATTCTTTGGGTGACAGCAAAATAGAAACATAGCTCAACACTTTTTATAACGACAAATTCAGCCATACAT
CGGCAAATGGAGATAGAAGA

Downstream 100 bases:

>100_bases
TTAATAACAACAAGAAGTGTTTGATCGTTTGTTGATCATAAATAGTTTGAGTTATTTGAAAACCTCTGTATTTATTCAGA
GGTTTTTTGTTTATTGATTT

Product: aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSEQLHKTALYEIHVAAGAKMVPFAGYEMPVQYPLGVKKEHLHTRNAAGLFDVSHMGQLRLKGKNAAAALEALVPVDIID
LPSQKQRYAFFTNDNGGIMDDLMVANFGDHLFVVVNAACKEQDIAHLVANLPSDVEIEVIEDRALLALQGPQAADVLSRL
QPSVSNMLFMDTAVVEISGIECYVSRSGYTGEDGYEISVPNDKAAELAETLTSFEEVEWIGLGARDSLRLECGLCLYGHD
LDTTTTPVEASLLWAISKNRRADGERVAGFPGADVILKQIETKDVNRKRVGLVGQTKAPVREGCKLYDADDNEIGIVTSG
TAGPTAGKPVSMAYVRTDLASLGTEVFADVRGKKLPMTVEKMPFVPQRYYRG

Sequences:

>Translated_372_residues
MSEQLHKTALYEIHVAAGAKMVPFAGYEMPVQYPLGVKKEHLHTRNAAGLFDVSHMGQLRLKGKNAAAALEALVPVDIID
LPSQKQRYAFFTNDNGGIMDDLMVANFGDHLFVVVNAACKEQDIAHLVANLPSDVEIEVIEDRALLALQGPQAADVLSRL
QPSVSNMLFMDTAVVEISGIECYVSRSGYTGEDGYEISVPNDKAAELAETLTSFEEVEWIGLGARDSLRLECGLCLYGHD
LDTTTTPVEASLLWAISKNRRADGERVAGFPGADVILKQIETKDVNRKRVGLVGQTKAPVREGCKLYDADDNEIGIVTSG
TAGPTAGKPVSMAYVRTDLASLGTEVFADVRGKKLPMTVEKMPFVPQRYYRG
>Mature_371_residues
SEQLHKTALYEIHVAAGAKMVPFAGYEMPVQYPLGVKKEHLHTRNAAGLFDVSHMGQLRLKGKNAAAALEALVPVDIIDL
PSQKQRYAFFTNDNGGIMDDLMVANFGDHLFVVVNAACKEQDIAHLVANLPSDVEIEVIEDRALLALQGPQAADVLSRLQ
PSVSNMLFMDTAVVEISGIECYVSRSGYTGEDGYEISVPNDKAAELAETLTSFEEVEWIGLGARDSLRLECGLCLYGHDL
DTTTTPVEASLLWAISKNRRADGERVAGFPGADVILKQIETKDVNRKRVGLVGQTKAPVREGCKLYDADDNEIGIVTSGT
AGPTAGKPVSMAYVRTDLASLGTEVFADVRGKKLPMTVEKMPFVPQRYYRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=377, Percent_Identity=46.4190981432361, Blast_Score=304, Evalue=8e-83,
Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=45.6582633053221, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI257796254, Length=370, Percent_Identity=42.1621621621622, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=45.0310559006211, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI24797151, Length=349, Percent_Identity=26.9340974212034, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI197927446, Length=240, Percent_Identity=25.4166666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI21361378, Length=240, Percent_Identity=25.4166666666667, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=34.9333333333333, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=43.0079155672823, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71994045, Length=385, Percent_Identity=23.3766233766234, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994052, Length=385, Percent_Identity=23.3766233766234, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=40.979381443299, Blast_Score=272, Evalue=6e-74,
Organism=Drosophila melanogaster, GI20129441, Length=381, Percent_Identity=45.6692913385827, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40446; Mature: 40314

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQLHKTALYEIHVAAGAKMVPFAGYEMPVQYPLGVKKEHLHTRNAAGLFDVSHMGQLR
CCCHHHHHEEEEEEECCCCEECCCCCCCCCEECCCCCCHHHHCCCCCCCEEECCCCCEEE
LKGKNAAAALEALVPVDIIDLPSQKQRYAFFTNDNGGIMDDLMVANFGDHLFVVVNAACK
ECCCCHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEECHHC
EQDIAHLVANLPSDVEIEVIEDRALLALQGPQAADVLSRLQPSVSNMLFMDTAVVEISGI
HHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHHHHHHHHCHHHHHEEEEEEEEEEEECE
ECYVSRSGYTGEDGYEISVPNDKAAELAETLTSFEEVEWIGLGARDSLRLECGLCLYGHD
EEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEEEEECC
LDTTTTPVEASLLWAISKNRRADGERVAGFPGADVILKQIETKDVNRKRVGLVGQTKAPV
CCCCCCCCCEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCH
REGCKLYDADDNEIGIVTSGTAGPTAGKPVSMAYVRTDLASLGTEVFADVRGKKLPMTVE
HHCCEEEECCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHH
KMPFVPQRYYRG
HCCCCCHHHCCC
>Mature Secondary Structure 
SEQLHKTALYEIHVAAGAKMVPFAGYEMPVQYPLGVKKEHLHTRNAAGLFDVSHMGQLR
CCHHHHHEEEEEEECCCCEECCCCCCCCCEECCCCCCHHHHCCCCCCCEEECCCCCEEE
LKGKNAAAALEALVPVDIIDLPSQKQRYAFFTNDNGGIMDDLMVANFGDHLFVVVNAACK
ECCCCHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEECHHC
EQDIAHLVANLPSDVEIEVIEDRALLALQGPQAADVLSRLQPSVSNMLFMDTAVVEISGI
HHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHHHHHHHHCHHHHHEEEEEEEEEEEECE
ECYVSRSGYTGEDGYEISVPNDKAAELAETLTSFEEVEWIGLGARDSLRLECGLCLYGHD
EEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEEEEECC
LDTTTTPVEASLLWAISKNRRADGERVAGFPGADVILKQIETKDVNRKRVGLVGQTKAPV
CCCCCCCCCEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCH
REGCKLYDADDNEIGIVTSGTAGPTAGKPVSMAYVRTDLASLGTEVFADVRGKKLPMTVE
HHCCEEEECCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHH
KMPFVPQRYYRG
HCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA