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The map label for this gene is guaC [H]

Identifier: 59713878

GI number: 59713878

Start: 771042

End: 772085

Strand: Reverse

Name: guaC [H]

Synonym: VF_A0695

Alternate gene names: 59713878

Gene position: 772085-771042 (Counterclockwise)

Preceding gene: 59713880

Following gene: 59713875

Centisome position: 58.04

GC content: 43.01

Gene sequence:

>1044_bases
ATGCGTATCGAACAAGAATTAAAGTTAGGCTTCAAAGATGTACTGTTTCGACCTAAGCGTTCAACGCTGAAAAGTCGCTC
TCAGGTTGAATTAACCCGCGATTTTACATTCAAACATAGCGGACGTCAATGGTCTGGTACACCTGTAATTGCAGCTAACA
TGGATTCTGTAGGTAGCTTTGCAATGGCGAAGGCATTATCTGAGCATGGTGTAATGACTGCTGTACATAAGCACTACACT
GTTGCTGATTGGGCTGAGTTTATTAAAGAGAACGATGCTTCTGTTCTTAAAAACGCAATGGTTTCTACTGGTACTTCAGA
AGCTGATTTCCAAAAAACTAAAGATATCATGGCATTAACCGATGATTTGATCTTTATTTGTATTGATATTGCGAATGGTT
ACTCTGAACACCTAGTTCAATATGTTGAAAAAGTGCGTGCTGAATTCCCTGATAAAGTGATTTCTGCGGGTAACGTTGTA
ACTGGTGATATGGTTGAAGAGCTTATCCTTGCTGGTGCAGATATTGTAAAAGTAGGTATTGGCCCAGGCTCTGTATGTAC
TACACGTGTTAAAACAGGTGTTGGTTACCCACAACTTTCTGCAATTATCGAATGTGCAGATGCTGCTCACGGTCTTGGTG
GTCGTATTATCGGTGACGGTGGTTGTTCGTGTGCGGGTGACGTATCTAAAGCGTTCGGCGGCGGTGCTGATTTCGTAATG
CTTGGTGGTATGCTAGCTGGTCACGAAGAGTCCGGCGGTGAAGTTATCGAACAAGATGGTAAGACGTTCATGAAGTTCTA
CGGAATGTCTTCACAAAGCGCGATGGACAAACACTCTGGTGGTGTTGCTAAGTACCGTGCTGCTGAAGGTAAAACCGTTC
TATTACCATTCCGTGGTTCAGTTCATAACACGATTTCTGACATCCTTGGTGGTGTACGTTCAACTTGTACATACGTAGGC
GCAGCAAAGCTTAAAGAGCTAACTAAGCGTACTACTTTCATTCGAGTACAAGAGCAAGAGAACAACGTTTTCGGTAAAGA
GTGA

Upstream 100 bases:

>100_bases
GCCCCGGTTTTTTTGTGCCTGCTATCTTGGTTTGTTAACTGCCTTCTGCCAAAGGCAACAAGAGGTAGTAGAGCCTTATC
GATAAGACGAGGAATTTATC

Downstream 100 bases:

>100_bases
TAACTCACTTTTAATGAAATAACGAATAAGTTAGGGTCGCAGTTTGCGACCCTTTTTTGTGTACGTAGAATAAAATTATA
TGGTAAACGTTTTTGGATGG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEQELKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGTPVIAANMDSVGSFAMAKALSEHGVMTAVHKHYT
VADWAEFIKENDASVLKNAMVSTGTSEADFQKTKDIMALTDDLIFICIDIANGYSEHLVQYVEKVRAEFPDKVISAGNVV
TGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGRIIGDGGCSCAGDVSKAFGGGADFVM
LGGMLAGHEESGGEVIEQDGKTFMKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFRGSVHNTISDILGGVRSTCTYVG
AAKLKELTKRTTFIRVQEQENNVFGKE

Sequences:

>Translated_347_residues
MRIEQELKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGTPVIAANMDSVGSFAMAKALSEHGVMTAVHKHYT
VADWAEFIKENDASVLKNAMVSTGTSEADFQKTKDIMALTDDLIFICIDIANGYSEHLVQYVEKVRAEFPDKVISAGNVV
TGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGRIIGDGGCSCAGDVSKAFGGGADFVM
LGGMLAGHEESGGEVIEQDGKTFMKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFRGSVHNTISDILGGVRSTCTYVG
AAKLKELTKRTTFIRVQEQENNVFGKE
>Mature_347_residues
MRIEQELKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGTPVIAANMDSVGSFAMAKALSEHGVMTAVHKHYT
VADWAEFIKENDASVLKNAMVSTGTSEADFQKTKDIMALTDDLIFICIDIANGYSEHLVQYVEKVRAEFPDKVISAGNVV
TGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGRIIGDGGCSCAGDVSKAFGGGADFVM
LGGMLAGHEESGGEVIEQDGKTFMKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFRGSVHNTISDILGGVRSTCTYVG
AAKLKELTKRTTFIRVQEQENNVFGKE

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=344, Percent_Identity=65.4069767441861, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI50541954, Length=342, Percent_Identity=65.7894736842105, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI50541952, Length=342, Percent_Identity=65.7894736842105, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI50541948, Length=342, Percent_Identity=65.7894736842105, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=63.8483965014577, Blast_Score=477, Evalue=1e-135,
Organism=Homo sapiens, GI66933016, Length=209, Percent_Identity=31.5789473684211, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI217035152, Length=252, Percent_Identity=31.7460317460317, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI34328930, Length=252, Percent_Identity=31.7460317460317, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI156616279, Length=252, Percent_Identity=31.7460317460317, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI217035148, Length=252, Percent_Identity=31.7460317460317, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI217035146, Length=252, Percent_Identity=31.7460317460317, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI34328928, Length=252, Percent_Identity=31.7460317460317, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI217035150, Length=252, Percent_Identity=31.7460317460317, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=74.1279069767442, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1788855, Length=218, Percent_Identity=38.9908256880734, Blast_Score=137, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=59.7667638483965, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71994385, Length=257, Percent_Identity=30.7392996108949, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71994389, Length=208, Percent_Identity=33.1730769230769, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=32.3404255319149, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=31.9148936170213, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=32.0675105485232, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24641071, Length=250, Percent_Identity=28.4, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24641073, Length=250, Percent_Identity=28.4, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI28571163, Length=250, Percent_Identity=28.4, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37225; Mature: 37225

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEQELKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGTPVIAANMDSVGSF
CCCHHHHHCCHHHHHCCCCHHHHHCCCCEEEECCEEEEECCCCCCCCEEEEECCCCHHHH
AMAKALSEHGVMTAVHKHYTVADWAEFIKENDASVLKNAMVSTGTSEADFQKTKDIMALT
HHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DDLIFICIDIANGYSEHLVQYVEKVRAEFPDKVISAGNVVTGDMVEELILAGADIVKVGI
HCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHCCCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGRIIGDGGCSCAGDVSKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCCCHHH
LGGMLAGHEESGGEVIEQDGKTFMKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFRGS
HCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCEEEEECCCC
VHNTISDILGGVRSTCTYVGAAKLKELTKRTTFIRVQEQENNVFGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure
MRIEQELKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGTPVIAANMDSVGSF
CCCHHHHHCCHHHHHCCCCHHHHHCCCCEEEECCEEEEECCCCCCCCEEEEECCCCHHHH
AMAKALSEHGVMTAVHKHYTVADWAEFIKENDASVLKNAMVSTGTSEADFQKTKDIMALT
HHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DDLIFICIDIANGYSEHLVQYVEKVRAEFPDKVISAGNVVTGDMVEELILAGADIVKVGI
HCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHCCCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGRIIGDGGCSCAGDVSKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCCCHHH
LGGMLAGHEESGGEVIEQDGKTFMKFYGMSSQSAMDKHSGGVAKYRAAEGKTVLLPFRGS
HCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCEEEEECCCC
VHNTISDILGGVRSTCTYVGAAKLKELTKRTTFIRVQEQENNVFGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]