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The map label for this gene is ace [H]

Identifier: 59713760

GI number: 59713760

Start: 661082

End: 661366

Strand: Reverse

Name: ace [H]

Synonym: VF_A0577

Alternate gene names: 59713760

Gene position: 661366-661082 (Counterclockwise)

Preceding gene: 59713761

Following gene: 59713759

Centisome position: 49.71

GC content: 29.12

Gene sequence:

>285_bases
ATGTTGGATTATATTTACTCTTGGTTTGTTGATGGTGTGGCTTTTTTAGTTATTGAATTAGCCGAGATGTTTTTAGAAAG
CAAATTATTTATTATCAAATTCTTTTGGGATGTATCTAATAACATTGTTTCTATGTTTTCTATTTATCCTCAAATTCAAT
CTGCCATAGATATGTTACCGCCACAATATAGTGGCATTCTGTTTTACCTTGGTTTAGATAAAGTATTTGCTATTTTAATT
CAGGCTCTATTAACTCGCTTTTCACTTCAGGTTTTTAAATTATGA

Upstream 100 bases:

>100_bases
TTTTTCCGTATTTAATGAGCATCTGGATTTAATTAGAAAGATATTACTTGCTGCGGCTTATATCTTTGCAGCTATGATTA
TATTTTTAAGGTAGCGCTAT

Downstream 100 bases:

>100_bases
GTATCTTTGTTCATCATGGCGCGCCTGGCTCTTATAAAACATCGGGAGCACTCTGGCTTAGGCTTCTTCCTGCGATTAAA
TCAGGCCGTCCTATAGTTAC

Product: enterotoxin

Products: NA

Alternate protein names: Ace [H]

Number of amino acids: Translated: 94; Mature: 94

Protein sequence:

>94_residues
MLDYIYSWFVDGVAFLVIELAEMFLESKLFIIKFFWDVSNNIVSMFSIYPQIQSAIDMLPPQYSGILFYLGLDKVFAILI
QALLTRFSLQVFKL

Sequences:

>Translated_94_residues
MLDYIYSWFVDGVAFLVIELAEMFLESKLFIIKFFWDVSNNIVSMFSIYPQIQSAIDMLPPQYSGILFYLGLDKVFAILI
QALLTRFSLQVFKL
>Mature_94_residues
MLDYIYSWFVDGVAFLVIELAEMFLESKLFIIKFFWDVSNNIVSMFSIYPQIQSAIDMLPPQYSGILFYLGLDKVFAILI
QALLTRFSLQVFKL

Specific function: Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020495
- InterPro:   IPR019670
- ProDom:   PD065768 [H]

Pfam domain/function: PF10734 DUF2523 [H]

EC number: NA

Molecular weight: Translated: 10989; Mature: 10989

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYIYSWFVDGVAFLVIELAEMFLESKLFIIKFFWDVSNNIVSMFSIYPQIQSAIDMLP
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PQYSGILFYLGLDKVFAILIQALLTRFSLQVFKL
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDYIYSWFVDGVAFLVIELAEMFLESKLFIIKFFWDVSNNIVSMFSIYPQIQSAIDMLP
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PQYSGILFYLGLDKVFAILIQALLTRFSLQVFKL
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8389476; 10952301 [H]