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The map label for this gene is ltaE [H]

Identifier: 59713680

GI number: 59713680

Start: 572200

End: 573204

Strand: Reverse

Name: ltaE [H]

Synonym: VF_A0497

Alternate gene names: 59713680

Gene position: 573204-572200 (Counterclockwise)

Preceding gene: 59713683

Following gene: 59713678

Centisome position: 43.09

GC content: 40.6

Gene sequence:

>1005_bases
ATGATTGATTTTCGCTCTGATACGGTTACTCGCCCAACTCCAAATATGCGTGAAGCTATCGCTAATGCTCTGGTTGGTGA
TGATGTTTATGGAGATGATCCAACCACAAACGAATTAGAACAATGGGCTGCTGATCGCCATGGTTTTGAAGCGGCAATGT
TCACTTCGTCAGGAACACAAGCAAACTTATTAGGACTTATGTCTCACTGTGAGCGTGGCGATGAGTATTTGTGTGGCCAA
CAAGCCCATAACTATAAATATGAAGCTGGTGGCGCAGCGGTATTAGGGTCAATCCAACCACAGCCGATTGAAAATAATCC
AGATGGTACTTTATGTTTTGAAAAACTGGCAGCAGCAATAAAAGCGGATGACTTCCATTTTGCCAGAACCAAACTATTGA
GCTTAGAAAACACCATTAATGGCAAGGTTCTTCCGTTAAGCTACTTAGCTCAAGCGCGAGAATTTGTGAACAAACATCAA
CTGGCTCTGCATTTAGATGGTGCTCGCGTCTATAATGCCGCAGTTGCACTAGATGTTGATATAAAAGAGATTGCTCAACA
TTTTGATAGTATGACGATTTGTTTATCAAAAGGCCTATCAGCACCAATTGGCTCTTTGCTACTTGGCACAAAAGAATACA
TCAAAAAAGCTCGCCGTATTAGAAAGATGCTGGGGGGCGGTATGCGTCAAACGGGCATTCTTGCTGCTGCCGGAAAACTC
GCATTAACCGAGCAAGTACCACAACTGGCCGTGGACCATGCCAATGCGAAATATTTAGCTGAACAGTTAAATACGGTAAA
TGGATTTTCAGTGAATGTTGAGCATATTCAAACTAATATTGTTTTTGCTAAATTAGACAACAAAGTAGATATCAAAACGA
TTTGTGATAAAGCACTTGAACAGGATATTTTACTTTCTGCTGGCAACCCTATTCGCTTTGTGACTCATAAAGACATCACA
AAACAAAATATTGATACCTTAATTGAGTTCTTAAAACAGAACTAA

Upstream 100 bases:

>100_bases
GTTATTTTTTTGTAAAACCCAAATAACATTGTTTTCATGGATACAAGCTGTGTGCTAGGTTATCTATCTATATAAAAATA
AGTGCAGTAAAGGATATACC

Downstream 100 bases:

>100_bases
TCTTATCCATTCCATCAATATAAAAAGAAAAGAGCAGCCAAATTCGCTGCTCTTTTTTATTACTTTACGGTGAAGTATTA
ACCTTCTATCACCTTCATTA

Product: L-allo-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MIDFRSDTVTRPTPNMREAIANALVGDDVYGDDPTTNELEQWAADRHGFEAAMFTSSGTQANLLGLMSHCERGDEYLCGQ
QAHNYKYEAGGAAVLGSIQPQPIENNPDGTLCFEKLAAAIKADDFHFARTKLLSLENTINGKVLPLSYLAQAREFVNKHQ
LALHLDGARVYNAAVALDVDIKEIAQHFDSMTICLSKGLSAPIGSLLLGTKEYIKKARRIRKMLGGGMRQTGILAAAGKL
ALTEQVPQLAVDHANAKYLAEQLNTVNGFSVNVEHIQTNIVFAKLDNKVDIKTICDKALEQDILLSAGNPIRFVTHKDIT
KQNIDTLIEFLKQN

Sequences:

>Translated_334_residues
MIDFRSDTVTRPTPNMREAIANALVGDDVYGDDPTTNELEQWAADRHGFEAAMFTSSGTQANLLGLMSHCERGDEYLCGQ
QAHNYKYEAGGAAVLGSIQPQPIENNPDGTLCFEKLAAAIKADDFHFARTKLLSLENTINGKVLPLSYLAQAREFVNKHQ
LALHLDGARVYNAAVALDVDIKEIAQHFDSMTICLSKGLSAPIGSLLLGTKEYIKKARRIRKMLGGGMRQTGILAAAGKL
ALTEQVPQLAVDHANAKYLAEQLNTVNGFSVNVEHIQTNIVFAKLDNKVDIKTICDKALEQDILLSAGNPIRFVTHKDIT
KQNIDTLIEFLKQN
>Mature_334_residues
MIDFRSDTVTRPTPNMREAIANALVGDDVYGDDPTTNELEQWAADRHGFEAAMFTSSGTQANLLGLMSHCERGDEYLCGQ
QAHNYKYEAGGAAVLGSIQPQPIENNPDGTLCFEKLAAAIKADDFHFARTKLLSLENTINGKVLPLSYLAQAREFVNKHQ
LALHLDGARVYNAAVALDVDIKEIAQHFDSMTICLSKGLSAPIGSLLLGTKEYIKKARRIRKMLGGGMRQTGILAAAGKL
ALTEQVPQLAVDHANAKYLAEQLNTVNGFSVNVEHIQTNIVFAKLDNKVDIKTICDKALEQDILLSAGNPIRFVTHKDIT
KQNIDTLIEFLKQN

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=324, Percent_Identity=56.1728395061728, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.907514450867, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.907514450867, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.907514450867, Blast_Score=259, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6320789, Length=333, Percent_Identity=36.9369369369369, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355439, Length=302, Percent_Identity=47.3509933774834, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36620; Mature: 36620

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFRSDTVTRPTPNMREAIANALVGDDVYGDDPTTNELEQWAADRHGFEAAMFTSSGTQ
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCH
ANLLGLMSHCERGDEYLCGQQAHNYKYEAGGAAVLGSIQPQPIENNPDGTLCFEKLAAAI
HHHHHHHHHHCCCCCCCCCCCCCCCEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHH
KADDFHFARTKLLSLENTINGKVLPLSYLAQAREFVNKHQLALHLDGARVYNAAVALDVD
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCEEEEECCHHEEEEEEEEECC
IKEIAQHFDSMTICLSKGLSAPIGSLLLGTKEYIKKARRIRKMLGGGMRQTGILAAAGKL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCH
ALTEQVPQLAVDHANAKYLAEQLNTVNGFSVNVEHIQTNIVFAKLDNKVDIKTICDKALE
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEHEEEEEEEEEEECCCCCCHHHHHHHHHH
QDILLSAGNPIRFVTHKDITKQNIDTLIEFLKQN
HHHEEECCCCEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDFRSDTVTRPTPNMREAIANALVGDDVYGDDPTTNELEQWAADRHGFEAAMFTSSGTQ
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCH
ANLLGLMSHCERGDEYLCGQQAHNYKYEAGGAAVLGSIQPQPIENNPDGTLCFEKLAAAI
HHHHHHHHHHCCCCCCCCCCCCCCCEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHH
KADDFHFARTKLLSLENTINGKVLPLSYLAQAREFVNKHQLALHLDGARVYNAAVALDVD
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCEEEEECCHHEEEEEEEEECC
IKEIAQHFDSMTICLSKGLSAPIGSLLLGTKEYIKKARRIRKMLGGGMRQTGILAAAGKL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCH
ALTEQVPQLAVDHANAKYLAEQLNTVNGFSVNVEHIQTNIVFAKLDNKVDIKTICDKALE
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEHEEEEEEEEEEECCCCCCHHHHHHHHHH
QDILLSAGNPIRFVTHKDITKQNIDTLIEFLKQN
HHHEEECCCCEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]