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The map label for this gene is mrdB [H]

Identifier: 59713666

GI number: 59713666

Start: 555673

End: 556770

Strand: Reverse

Name: mrdB [H]

Synonym: VF_A0483

Alternate gene names: 59713666

Gene position: 556770-555673 (Counterclockwise)

Preceding gene: 59713667

Following gene: 59713665

Centisome position: 41.85

GC content: 41.89

Gene sequence:

>1098_bases
ATGTATGACTACAAACCACGAATAGACTACGCTTTACTTGCTGCAATTTTAGTATTAATTGTGCTTGGATCTTTAACCGT
TTGGAGCGCAAGTGGTTTTAGTGAGCCTATGTTAGAGCGCCACTTAATACGAGCAATGATCGCTGTTGGTTGTATCGTCG
TGATGTCAGGCATATCCCCTATGCACTATCAACGCTCGGCCCCCTTTCTATATGGGTTAGCTGTTGTTCTTCTCATTGGA
GTAATTATTGCTGGTGATAGCACTAACGGTTCACAACGTTGGTTAGTCATAGGTCCAATTCGATTTCAACCTTCCGAATT
AGTTAAAGTTGCCATTCCCCTCATGGTTGCTTGGATATTAGCAGCAGAAGCCACACGCCCTGATTTAAAAAAAATAGGGA
TTTGTTTGCTTGTTACTGCTGTGCCTGCCGGTTTGATTTTTATTCAACCCGACCTTGATGGTGCCATTTTTACTGTTATA
TATGCCCTGTTTGTCCTGTACTTTGCCGGTATGAGTTGGAAAATCATCGGCTCTTTTCTAGCAACCGTAGCGACTGCCGT
CCCGCTTTTGTGGATCTTTGTTATGGAAGCGTATCAGAAGAAGCGTGTTACTCAGTTTCTTGACCCTGAGTCGGATCCTC
TTGGAGCTGGTTACCAAATTATTCAATCTTTAATCGCTATTGGCTCTGGTGGGATACGCGGTAAAGGCTGGATGAATGCG
ACACAAGGACACCTGGGGTTCATTCCAGAAAGTCATACTGACTTCATTTTTTCTACTTATGCAGAAGAATGGGGATTTTT
TGGCTGCGCTCTACTGCTATCACTGTATTTATTTATCACTGGACGAGTAATTTGGTTAGCTTATCAAAGTGAAAGCACCT
TTACTCGTTTGGTAAGTAGTACCTTTGCATTAAGCTTTTTCTTATATGCTTTCATTAATATGGGTATGGTAAGTGGTTTA
CTTCCAGTTATGGGTAGCCCACTGCCTTTCTTCAGTTATGGTGGTACAGCAATGATAACCCAAGGTATTTGCTTTGGTAT
TGTCATGTCATTGTGTTTATACAAACCATACAAGCCAAACCGTCCAGATAGACTCTAA

Upstream 100 bases:

>100_bases
GCATTAATATATTGCATTTATTTATAAAGAGGTTAATTTAGGTCTCCTTATCAACACCGCAAACACCGTGTATTTTCACT
TTGTCTGATGAATTAACATT

Downstream 100 bases:

>100_bases
TGCTTTTTTACTGTCATAAGTCGTTCATTATTCACTCATTTGAATTATGAACTTTTTATGACAGTGAATATTTATAGTGA
CATTATCAATAACTTGGCAT

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MYDYKPRIDYALLAAILVLIVLGSLTVWSASGFSEPMLERHLIRAMIAVGCIVVMSGISPMHYQRSAPFLYGLAVVLLIG
VIIAGDSTNGSQRWLVIGPIRFQPSELVKVAIPLMVAWILAAEATRPDLKKIGICLLVTAVPAGLIFIQPDLDGAIFTVI
YALFVLYFAGMSWKIIGSFLATVATAVPLLWIFVMEAYQKKRVTQFLDPESDPLGAGYQIIQSLIAIGSGGIRGKGWMNA
TQGHLGFIPESHTDFIFSTYAEEWGFFGCALLLSLYLFITGRVIWLAYQSESTFTRLVSSTFALSFFLYAFINMGMVSGL
LPVMGSPLPFFSYGGTAMITQGICFGIVMSLCLYKPYKPNRPDRL

Sequences:

>Translated_365_residues
MYDYKPRIDYALLAAILVLIVLGSLTVWSASGFSEPMLERHLIRAMIAVGCIVVMSGISPMHYQRSAPFLYGLAVVLLIG
VIIAGDSTNGSQRWLVIGPIRFQPSELVKVAIPLMVAWILAAEATRPDLKKIGICLLVTAVPAGLIFIQPDLDGAIFTVI
YALFVLYFAGMSWKIIGSFLATVATAVPLLWIFVMEAYQKKRVTQFLDPESDPLGAGYQIIQSLIAIGSGGIRGKGWMNA
TQGHLGFIPESHTDFIFSTYAEEWGFFGCALLLSLYLFITGRVIWLAYQSESTFTRLVSSTFALSFFLYAFINMGMVSGL
LPVMGSPLPFFSYGGTAMITQGICFGIVMSLCLYKPYKPNRPDRL
>Mature_365_residues
MYDYKPRIDYALLAAILVLIVLGSLTVWSASGFSEPMLERHLIRAMIAVGCIVVMSGISPMHYQRSAPFLYGLAVVLLIG
VIIAGDSTNGSQRWLVIGPIRFQPSELVKVAIPLMVAWILAAEATRPDLKKIGICLLVTAVPAGLIFIQPDLDGAIFTVI
YALFVLYFAGMSWKIIGSFLATVATAVPLLWIFVMEAYQKKRVTQFLDPESDPLGAGYQIIQSLIAIGSGGIRGKGWMNA
TQGHLGFIPESHTDFIFSTYAEEWGFFGCALLLSLYLFITGRVIWLAYQSESTFTRLVSSTFALSFFLYAFINMGMVSGL
LPVMGSPLPFFSYGGTAMITQGICFGIVMSLCLYKPYKPNRPDRL

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=351, Percent_Identity=47.008547008547, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1786277, Length=289, Percent_Identity=33.9100346020761, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40085; Mature: 40085

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDYKPRIDYALLAAILVLIVLGSLTVWSASGFSEPMLERHLIRAMIAVGCIVVMSGISP
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
MHYQRSAPFLYGLAVVLLIGVIIAGDSTNGSQRWLVIGPIRFQPSELVKVAIPLMVAWIL
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
AAEATRPDLKKIGICLLVTAVPAGLIFIQPDLDGAIFTVIYALFVLYFAGMSWKIIGSFL
HHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
ATVATAVPLLWIFVMEAYQKKRVTQFLDPESDPLGAGYQIIQSLIAIGSGGIRGKGWMNA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
TQGHLGFIPESHTDFIFSTYAEEWGFFGCALLLSLYLFITGRVIWLAYQSESTFTRLVSS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHH
TFALSFFLYAFINMGMVSGLLPVMGSPLPFFSYGGTAMITQGICFGIVMSLCLYKPYKPN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
RPDRL
CCCCC
>Mature Secondary Structure
MYDYKPRIDYALLAAILVLIVLGSLTVWSASGFSEPMLERHLIRAMIAVGCIVVMSGISP
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
MHYQRSAPFLYGLAVVLLIGVIIAGDSTNGSQRWLVIGPIRFQPSELVKVAIPLMVAWIL
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
AAEATRPDLKKIGICLLVTAVPAGLIFIQPDLDGAIFTVIYALFVLYFAGMSWKIIGSFL
HHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
ATVATAVPLLWIFVMEAYQKKRVTQFLDPESDPLGAGYQIIQSLIAIGSGGIRGKGWMNA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
TQGHLGFIPESHTDFIFSTYAEEWGFFGCALLLSLYLFITGRVIWLAYQSESTFTRLVSS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHH
TFALSFFLYAFINMGMVSGLLPVMGSPLPFFSYGGTAMITQGICFGIVMSLCLYKPYKPN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
RPDRL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]