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The map label for this gene is hutH

Identifier: 59713633

GI number: 59713633

Start: 517423

End: 518955

Strand: Reverse

Name: hutH

Synonym: VF_A0450

Alternate gene names: 59713633

Gene position: 518955-517423 (Counterclockwise)

Preceding gene: 59713634

Following gene: 59713632

Centisome position: 39.01

GC content: 42.4

Gene sequence:

>1533_bases
ATGTATTCATTAGAAATTATTCCAGGTAAATTATCACTAAAACAATTACGTGAAGTTAGCCGTCACCCTACAAAATTGTC
GTTAGACCCTAACGCTCTGCCTGATATGCTCATCAGTGCAGATGTTGTCGCTCAAGTCATAGAAGAAGGTAAAACCGTTT
ACGGTATTAATACAGGGTTTGGTTTACTCGCTAATACGCGTATTGCTGAAAAAGATTTAGAAACACTACAGCGAAGTATT
GTACTTTCTCATGCAGCTGGTATTGGTGAGTTTATGGATGATGCGACTGTTCGCTTGATGATGGTACTCAAAATAAATAG
TCTTGCTAGAGGTTATTCAGGTATTCGCCCTTTAGTTATTGACGCTTTAATACAATTAGTCAATTCAGAAGTCTATCCGT
GCATCCCCAAAAAAGGGTCTGTTGGGGCTTCTGGGGATCTTGCCCCATTAGCTCACATGAGTACCGTTCTATTAGGAGAA
GGTGAGGCTCGCTATCGAGGTGAAGTAATCACAGGAAAAACAGCATTAGAAATAGCTGGGTTAACTCCAATAACACTGGC
ACCAAAAGAAGGACTAGCCCTACTTAATGGCACCCAAGCCTCTACAGCATTTGCACTTGAAGGTTTATTTGCGGCTGAAG
ACCTTTACGCTTCAGCCACTGTTTGTGGTGCCATGTCTGTAGAAGCCGCTCTTGGTAGTCGTAAACCATTTGATCCACGA
ATTCATCGTGTGCGTGGTCATCGCAGCCAAATGGATGCCGCACTTGCTTATCGACACCTTTTAGCTCAAAGCAGTGACAT
AGGCCTGTCTCACCAATGTTGTGAACGAGTACAAGATCCCTATTCACTTCGATGCCAACCACAGGTAATGGGAGCATGTT
TACAGCAGATCCGAAACTCTGCTGATATATTAGAGATTGAAGCCAATTCAGTCTCTGACAATCCGCTTGTCTTTGCGGAT
GATGGCGACATTATTTCTGGTGGTAATTTCCATGCAGAGCCAGTCGCCATGGCCGCAGATAATCTTGCTTTAGCCATTTC
AGAAATAGGCAGTTTATCAGAGCGTAGAATGGCGCTTTTAATTGACAGTGGATTAAGCAAATTACCTCCATTTTTGGTGG
ATAATGGTGGTGTAAATTCTGGCTTTATGATTGCACAAGTAACCGCTGCAGCATTAGCTAGTGAAAACAAGACGCTAGCA
CACCCCGCCTCAATTGATAGTTTACCAACTTCAGCAAACCAAGAAGATCATGTCTCTATGGCGACATTTGCAGGACGTCG
ATTAGGCGATATGGCAGAAAACACACGTGGTATTTTGGCCGTTGAACTATTAGCCGCAGCTCAAGGTCTCGATTTTAGAG
CGCCAAACAAAAGCTCAAATAGAATAGAAAAAGCAAAAGAACTGCTACGTGAACGTGTTGATTTTTATGATAAAGATCGT
TACTTCGCACCAGATATCGCAAAAGCCAACTCGTTATTAAAAGAAGCCGTATATAATCATTTAATGCCCGATACCTTACT
TCCTAGTATATAA

Upstream 100 bases:

>100_bases
TCAATTGTGCAAAAGAACAAAACCTAGATTTACCTATGTTATCCATACCTAACAAATAAATTAATACTAATAAAAATAAA
ACTATAATGAGAAGAAAACT

Downstream 100 bases:

>100_bases
AAACTCATACCCTTGGAGATAATACTATCTCTAAGGGTATTCTTTCCCAATTTGAGTCTTCATTTTTTATCAGTACAATA
TCAATACATTCAATAAATCA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MYSLEIIPGKLSLKQLREVSRHPTKLSLDPNALPDMLISADVVAQVIEEGKTVYGINTGFGLLANTRIAEKDLETLQRSI
VLSHAAGIGEFMDDATVRLMMVLKINSLARGYSGIRPLVIDALIQLVNSEVYPCIPKKGSVGASGDLAPLAHMSTVLLGE
GEARYRGEVITGKTALEIAGLTPITLAPKEGLALLNGTQASTAFALEGLFAAEDLYASATVCGAMSVEAALGSRKPFDPR
IHRVRGHRSQMDAALAYRHLLAQSSDIGLSHQCCERVQDPYSLRCQPQVMGACLQQIRNSADILEIEANSVSDNPLVFAD
DGDIISGGNFHAEPVAMAADNLALAISEIGSLSERRMALLIDSGLSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLA
HPASIDSLPTSANQEDHVSMATFAGRRLGDMAENTRGILAVELLAAAQGLDFRAPNKSSNRIEKAKELLRERVDFYDKDR
YFAPDIAKANSLLKEAVYNHLMPDTLLPSI

Sequences:

>Translated_510_residues
MYSLEIIPGKLSLKQLREVSRHPTKLSLDPNALPDMLISADVVAQVIEEGKTVYGINTGFGLLANTRIAEKDLETLQRSI
VLSHAAGIGEFMDDATVRLMMVLKINSLARGYSGIRPLVIDALIQLVNSEVYPCIPKKGSVGASGDLAPLAHMSTVLLGE
GEARYRGEVITGKTALEIAGLTPITLAPKEGLALLNGTQASTAFALEGLFAAEDLYASATVCGAMSVEAALGSRKPFDPR
IHRVRGHRSQMDAALAYRHLLAQSSDIGLSHQCCERVQDPYSLRCQPQVMGACLQQIRNSADILEIEANSVSDNPLVFAD
DGDIISGGNFHAEPVAMAADNLALAISEIGSLSERRMALLIDSGLSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLA
HPASIDSLPTSANQEDHVSMATFAGRRLGDMAENTRGILAVELLAAAQGLDFRAPNKSSNRIEKAKELLRERVDFYDKDR
YFAPDIAKANSLLKEAVYNHLMPDTLLPSI
>Mature_510_residues
MYSLEIIPGKLSLKQLREVSRHPTKLSLDPNALPDMLISADVVAQVIEEGKTVYGINTGFGLLANTRIAEKDLETLQRSI
VLSHAAGIGEFMDDATVRLMMVLKINSLARGYSGIRPLVIDALIQLVNSEVYPCIPKKGSVGASGDLAPLAHMSTVLLGE
GEARYRGEVITGKTALEIAGLTPITLAPKEGLALLNGTQASTAFALEGLFAAEDLYASATVCGAMSVEAALGSRKPFDPR
IHRVRGHRSQMDAALAYRHLLAQSSDIGLSHQCCERVQDPYSLRCQPQVMGACLQQIRNSADILEIEANSVSDNPLVFAD
DGDIISGGNFHAEPVAMAADNLALAISEIGSLSERRMALLIDSGLSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLA
HPASIDSLPTSANQEDHVSMATFAGRRLGDMAENTRGILAVELLAAAQGLDFRAPNKSSNRIEKAKELLRERVDFYDKDR
YFAPDIAKANSLLKEAVYNHLMPDTLLPSI

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=496, Percent_Identity=44.3548387096774, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567831, Length=469, Percent_Identity=42.8571428571429, Blast_Score=357, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_VIBF1 (Q5E0C6)

Other databases:

- EMBL:   CP000021
- RefSeq:   YP_206408.1
- ProteinModelPortal:   Q5E0C6
- SMR:   Q5E0C6
- STRING:   Q5E0C6
- GeneID:   3279917
- GenomeReviews:   CP000021_GR
- KEGG:   vfi:VF_A0450
- NMPDR:   fig|312309.3.peg.2769
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   VFIS312309:VFA0450-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54610; Mature: 54610

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLEIIPGKLSLKQLREVSRHPTKLSLDPNALPDMLISADVVAQVIEEGKTVYGINTGF
CCEEEEECCCCCHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
GLLANTRIAEKDLETLQRSIVLSHAAGIGEFMDDATVRLMMVLKINSLARGYSGIRPLVI
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
DALIQLVNSEVYPCIPKKGSVGASGDLAPLAHMSTVLLGEGEARYRGEVITGKTALEIAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCEEEECCCEEEECC
LTPITLAPKEGLALLNGTQASTAFALEGLFAAEDLYASATVCGAMSVEAALGSRKPFDPR
CCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHRVRGHRSQMDAALAYRHLLAQSSDIGLSHQCCERVQDPYSLRCQPQVMGACLQQIRNS
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
ADILEIEANSVSDNPLVFADDGDIISGGNFHAEPVAMAADNLALAISEIGSLSERRMALL
CCEEEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHHHHHHE
IDSGLSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLAHPASIDSLPTSANQEDHVSM
ECCCHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAGRRLGDMAENTRGILAVELLAAAQGLDFRAPNKSSNRIEKAKELLRERVDFYDKDR
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHCCCC
YFAPDIAKANSLLKEAVYNHLMPDTLLPSI
CCCCCHHHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MYSLEIIPGKLSLKQLREVSRHPTKLSLDPNALPDMLISADVVAQVIEEGKTVYGINTGF
CCEEEEECCCCCHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
GLLANTRIAEKDLETLQRSIVLSHAAGIGEFMDDATVRLMMVLKINSLARGYSGIRPLVI
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
DALIQLVNSEVYPCIPKKGSVGASGDLAPLAHMSTVLLGEGEARYRGEVITGKTALEIAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCEEEECCCEEEECC
LTPITLAPKEGLALLNGTQASTAFALEGLFAAEDLYASATVCGAMSVEAALGSRKPFDPR
CCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHRVRGHRSQMDAALAYRHLLAQSSDIGLSHQCCERVQDPYSLRCQPQVMGACLQQIRNS
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
ADILEIEANSVSDNPLVFADDGDIISGGNFHAEPVAMAADNLALAISEIGSLSERRMALL
CCEEEEECCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHHHHHHE
IDSGLSKLPPFLVDNGGVNSGFMIAQVTAAALASENKTLAHPASIDSLPTSANQEDHVSM
ECCCHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAGRRLGDMAENTRGILAVELLAAAQGLDFRAPNKSSNRIEKAKELLRERVDFYDKDR
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHCCCC
YFAPDIAKANSLLKEAVYNHLMPDTLLPSI
CCCCCHHHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA