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The map label for this gene is cusR [H]

Identifier: 59713619

GI number: 59713619

Start: 499648

End: 500325

Strand: Reverse

Name: cusR [H]

Synonym: VF_A0436

Alternate gene names: 59713619

Gene position: 500325-499648 (Counterclockwise)

Preceding gene: 59713621

Following gene: 59713618

Centisome position: 37.61

GC content: 36.14

Gene sequence:

>678_bases
ATGAAAATATTGGTTATTGAAGACGACCAAACAACTCGAGATTTTGTGACTAAAGCGCTAGAACAAGAAGGCTTCATTGT
TGATAGTTCTGATGATGGCAAAGAAGGTTTAATGATGGCGATAAGTTGTGATTATCAATTAATCATTCTTGACCGCATGC
TACCTAATCTTGATGGGTTAAAAATCCTATCAGCAATTCGTGCTACAGGAAATAATACCCCTGTGCTTATTCTTAGTGCA
TTAGATAGCGTCGATCAAAGGGTTGAAGGACTTACTGCAGGTAGTGACGATTACCTAACCAAACCTTTTGCTTTAGCTGA
GCTATTAGCTCGTATCAATATCATATTACGTCGAAATAGACCGATTGAAAGTGCTTCTAACGAACTGAAAATTAAGAATT
TAAACATCAATTTACGTTCGCAAAAAGTCACGATCAATGACAACATTGTTCCATTACAAAATAAAGAATTTATTTTATTA
CGTTATCTTGCGGAAAATGCTGATGAAGTGGTTTCTCGAATGCGATTATTTGAAGCTGCATGGGATTATCACTTTGATCC
AAAAACCAATGTTATTGATGTTCATATTGCTAAGTTACGCAAAAAATTAGATAACTCTGGAGCTGTGGATCTCATCGAAA
CCGTACGTGGAGCTGGTTATGTTCTTAGAACAACGTGA

Upstream 100 bases:

>100_bases
CTAGTCCTTAGAATTGAGAGTCATTACTTAGTTTTTTCTATAATTGTGAATCAACACTTTTTTCTTGTTATAATAAAATC
TCTAAATAAGAGAGTAAGTT

Downstream 100 bases:

>100_bases
TGAGCTTTACCGTTCCTCCATTTTAAAATTATTAATATGGTTTGCTATCGGGTTATTTTTAGTTATGGGGTTGATTATTT
ACCAACTCTATTCAACTTCT

Product: putative transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILVIEDDQTTRDFVTKALEQEGFIVDSSDDGKEGLMMAISCDYQLIILDRMLPNLDGLKILSAIRATGNNTPVLILSA
LDSVDQRVEGLTAGSDDYLTKPFALAELLARINIILRRNRPIESASNELKIKNLNINLRSQKVTINDNIVPLQNKEFILL
RYLAENADEVVSRMRLFEAAWDYHFDPKTNVIDVHIAKLRKKLDNSGAVDLIETVRGAGYVLRTT

Sequences:

>Translated_225_residues
MKILVIEDDQTTRDFVTKALEQEGFIVDSSDDGKEGLMMAISCDYQLIILDRMLPNLDGLKILSAIRATGNNTPVLILSA
LDSVDQRVEGLTAGSDDYLTKPFALAELLARINIILRRNRPIESASNELKIKNLNINLRSQKVTINDNIVPLQNKEFILL
RYLAENADEVVSRMRLFEAAWDYHFDPKTNVIDVHIAKLRKKLDNSGAVDLIETVRGAGYVLRTT
>Mature_225_residues
MKILVIEDDQTTRDFVTKALEQEGFIVDSSDDGKEGLMMAISCDYQLIILDRMLPNLDGLKILSAIRATGNNTPVLILSA
LDSVDQRVEGLTAGSDDYLTKPFALAELLARINIILRRNRPIESASNELKIKNLNINLRSQKVTINDNIVPLQNKEFILL
RYLAENADEVVSRMRLFEAAWDYHFDPKTNVIDVHIAKLRKKLDNSGAVDLIETVRGAGYVLRTT

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=43.2432432432432, Blast_Score=195, Evalue=2e-51,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=44.5454545454545, Blast_Score=187, Evalue=4e-49,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=40.5405405405405, Blast_Score=154, Evalue=3e-39,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=37.8378378378378, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.4444444444444, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.981981981982, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.9649122807018, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.4324324324324, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786911, Length=206, Percent_Identity=31.5533980582524, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=29.5454545454545, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.0748898678414, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.1310043668122, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=129, Percent_Identity=29.4573643410853, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.8842975206612, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=135, Percent_Identity=27.4074074074074, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25284; Mature: 25284

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVIEDDQTTRDFVTKALEQEGFIVDSSDDGKEGLMMAISCDYQLIILDRMLPNLDGL
CEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCEEEEEEEHHCCCCCHH
KILSAIRATGNNTPVLILSALDSVDQRVEGLTAGSDDYLTKPFALAELLARINIILRRNR
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCC
PIESASNELKIKNLNINLRSQKVTINDNIVPLQNKEFILLRYLAENADEVVSRMRLFEAA
CCCCCCCCEEEEEEEEEEEEEEEEECCCEEECCCCCEEEEHHHHCCHHHHHHHHHHHHHH
WDYHFDPKTNVIDVHIAKLRKKLDNSGAVDLIETVRGAGYVLRTT
HCCCCCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKILVIEDDQTTRDFVTKALEQEGFIVDSSDDGKEGLMMAISCDYQLIILDRMLPNLDGL
CEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCEEEEEEEHHCCCCCHH
KILSAIRATGNNTPVLILSALDSVDQRVEGLTAGSDDYLTKPFALAELLARINIILRRNR
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCC
PIESASNELKIKNLNINLRSQKVTINDNIVPLQNKEFILLRYLAENADEVVSRMRLFEAA
CCCCCCCCEEEEEEEEEEEEEEEEECCCEEECCCCCEEEEHHHHCCHHHHHHHHHHHHHH
WDYHFDPKTNVIDVHIAKLRKKLDNSGAVDLIETVRGAGYVLRTT
HCCCCCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]