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The map label for this gene is czcR [H]

Identifier: 59713449

GI number: 59713449

Start: 297807

End: 298472

Strand: Reverse

Name: czcR [H]

Synonym: VF_A0266

Alternate gene names: 59713449

Gene position: 298472-297807 (Counterclockwise)

Preceding gene: 59713452

Following gene: 59713448

Centisome position: 22.44

GC content: 36.64

Gene sequence:

>666_bases
ATGAAAGTATTGATTGTTGAAGATAATCACCATGTAGCAGAAACCATTGCTGATTATTTAGAACTTGTTGGAATTGACAT
TGACTGTGCTTATCACGGTGCAGCGGCCATCGAAATATTAAAAGAAGAAACCTTTGATGTTATTGTCATGGATATCATGA
TGCCCAAGCTCGACGGTATTAGTACCGTTGAAGTTCTGCGTAATGATTATGCTTGTAGCACGCCTATTCTTTTTTTAACC
GCTAAAGATACATTAGAAGATAAGATTCATGCTTTTGAAGTCGGTGGTGATGATTATTTAGTTAAACCGTTTGCCATGGA
AGAACTTCACGTACGCTTATTAGCTTTATCTAAACGAGGCAGAAGAACTGACATAGGTAAACTGACCTTTGAAGACATGG
AAATGGATGTAAAAGCAGGCACGTTATATCGCCAACAAAAACTCATTAAATTAGCGCCGATACAATTAAAAATCATTGCG
TTATTAATGAAAAAAGCACCTGATATTGTTAGTAAAAATGAAGTCATTGAACACGTTTGGGGTGATGAATCACCATCAAG
TGATGCCCTAAGAAGCCACTTGTACACCATAAGAAACGCCATTGATAAAGATTTTGATATTCCAAGACTAGAGACCATTC
ATGGAAAAGGCTACCGACTTAAATAA

Upstream 100 bases:

>100_bases
AAACAGCAACTTTCTTCATTTTTTAACCTAATTATTATATTTAATGCAATTTATGAGGGTAAAATAGCGTACAGAGTGTG
AAGGATTCGTGAAGAAGAAG

Downstream 100 bases:

>100_bases
AGGCTCGCAACAACCAAGCTTTTTTAAAAAAATCCGTTGGACATTTGGCATCCTCACTTTTTTGATGTTCGGATTATTCT
GGGCGGTTATTTATATTGCA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKVLIVEDNHHVAETIADYLELVGIDIDCAYHGAAAIEILKEETFDVIVMDIMMPKLDGISTVEVLRNDYACSTPILFLT
AKDTLEDKIHAFEVGGDDYLVKPFAMEELHVRLLALSKRGRRTDIGKLTFEDMEMDVKAGTLYRQQKLIKLAPIQLKIIA
LLMKKAPDIVSKNEVIEHVWGDESPSSDALRSHLYTIRNAIDKDFDIPRLETIHGKGYRLK

Sequences:

>Translated_221_residues
MKVLIVEDNHHVAETIADYLELVGIDIDCAYHGAAAIEILKEETFDVIVMDIMMPKLDGISTVEVLRNDYACSTPILFLT
AKDTLEDKIHAFEVGGDDYLVKPFAMEELHVRLLALSKRGRRTDIGKLTFEDMEMDVKAGTLYRQQKLIKLAPIQLKIIA
LLMKKAPDIVSKNEVIEHVWGDESPSSDALRSHLYTIRNAIDKDFDIPRLETIHGKGYRLK
>Mature_221_residues
MKVLIVEDNHHVAETIADYLELVGIDIDCAYHGAAAIEILKEETFDVIVMDIMMPKLDGISTVEVLRNDYACSTPILFLT
AKDTLEDKIHAFEVGGDDYLVKPFAMEELHVRLLALSKRGRRTDIGKLTFEDMEMDVKAGTLYRQQKLIKLAPIQLKIIA
LLMKKAPDIVSKNEVIEHVWGDESPSSDALRSHLYTIRNAIDKDFDIPRLETIHGKGYRLK

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=30.4932735426009, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=28.8288288288288, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=28.310502283105, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=30.4932735426009, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=26.1261261261261, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.82096069869, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=24.7787610619469, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=24.8888888888889, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=24.1071428571429, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=32.7272727272727, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=24.6696035242291, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=28.8288288288288, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=115, Percent_Identity=34.7826086956522, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=119, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=112, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25034; Mature: 25034

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIVEDNHHVAETIADYLELVGIDIDCAYHGAAAIEILKEETFDVIVMDIMMPKLDGI
CEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCHHEEEEEHHHCCCCCC
STVEVLRNDYACSTPILFLTAKDTLEDKIHAFEVGGDDYLVKPFAMEELHVRLLALSKRG
HHHHHHHCCCCCCCCEEEEEECHHHHCCEEEEEECCCCEEECCHHHHHHHHHHHHHHCCC
RRTDIGKLTFEDMEMDVKAGTLYRQQKLIKLAPIQLKIIALLMKKAPDIVSKNEVIEHVW
CCCCCCCEEHHHHEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHC
GDESPSSDALRSHLYTIRNAIDKDFDIPRLETIHGKGYRLK
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEECC
>Mature Secondary Structure
MKVLIVEDNHHVAETIADYLELVGIDIDCAYHGAAAIEILKEETFDVIVMDIMMPKLDGI
CEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCHHEEEEEHHHCCCCCC
STVEVLRNDYACSTPILFLTAKDTLEDKIHAFEVGGDDYLVKPFAMEELHVRLLALSKRG
HHHHHHHCCCCCCCCEEEEEECHHHHCCEEEEEECCCCEEECCHHHHHHHHHHHHHHCCC
RRTDIGKLTFEDMEMDVKAGTLYRQQKLIKLAPIQLKIIALLMKKAPDIVSKNEVIEHVW
CCCCCCCEEHHHHEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHC
GDESPSSDALRSHLYTIRNAIDKDFDIPRLETIHGKGYRLK
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]