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The map label for this gene is kefC [H]

Identifier: 59713443

GI number: 59713443

Start: 291668

End: 293584

Strand: Reverse

Name: kefC [H]

Synonym: VF_A0260

Alternate gene names: 59713443

Gene position: 293584-291668 (Counterclockwise)

Preceding gene: 59713444

Following gene: 59713442

Centisome position: 22.07

GC content: 39.8

Gene sequence:

>1917_bases
ATGACTGGATATTTTTTACAAGCTTTTATCTACCTTGTTGCTGCTGTTATTGCTGTACCAATCGCTAAACGTCTAGGACT
TGGTTCTGTTCTTGGTTACTTAATTGCAGGGGTGGTTATAGGACCAATCATTGGTCTTGTTGGCGAAGAAACAACGACTA
TTCAACATTTTGCCGAATTTGGCGTTGTTATGATGCTATTTCTTGTCGGTTTAGAACTTGAACCTAAAATGCTATGGAAT
ATGCGTAACCGTCTCATGGGATTAGGAGGACTGCAAGTGGTCGGCACTACAGCGGTCGTAATGGGTCTTGCTATGTTCTT
CGGCCAATCATGGACTATTGCACTGACCATTGGCCTAATCTTTGCCCTATCATCCACAGCGATAGTATTGCAAACATTCA
ATGAAAAAGGATTGGCCAAAACAGAAGGCGGCCAAAATGCTTTCTCGGTATTACTTTTTCAAGATATTGCTGTGATCCCA
ATGCTAGCTTTTATTCCACTATTAGCTTTACCTGAATTAGTAGCAAAAGCGCAATTGGCAGCCGCAACCGCTGCTGAGCA
TCATGAAGAATTAACCCTCGTTGCAGGTCTTCCTGGTTGGGCATATGGGCTAGTGATTACCGCATCCATCGCATTAGTTG
TCGTTGGCGGTCATTATTTAAGTCGTCCTCTATTTCGCTTTGTAGCAAGCTCTGGACTTAGAGAAATATTCACAGCAACA
GCACTCATGCTTGTTATTGGTATTGCAGCCTTAATGAGTTTAGTCGGCCTATCTCCAGCTCTAGGTACTTTCCTTGCTGG
TGTTGTTTTAGCAAACTCAGAATTTAGACATGAACTTGAATCCAACATAGATCCATTTAAAGGGCTTTTATTGGGATTAT
TCTTCATTACCGTAGGTGCAGGAATCGATTTTGGTATTCTATTTAATGATTTCTTCTTAATCATCGGTTTAACAATCGGT
GTCATGGTACTAAAAGCGGCTGTTTTATATATATTAGCTCTGATCTTTAAGATCAAAAACAGTAACCGTTGGTTATTTAC
GCTTAGCCTAGCGCAAGCAGGGGAATTTGGGTTTGTTTTATTAAGTTTTACCGTTCAAAACCATGTATTACCACAAGAAG
TCGCTCAACCATTGTCATTGGTTGTTGCTCTTTCTATGTTCTTTACCCCAGGTTTATTTATCTTATTTGATAAAGTAATT
CTGCCTAAATTTGAACAACAATCAAATGAAAGAGAAAGTGACACAATTGAAGAAAAAGGCACGGTAATTATTGCTGGTGG
CGGTCGGTTCGGCCAAGTCGTCAACCGTTTCTTAGTATCTAATCATGTAAATACTGTTGTACTCGATCATCAAGCAGATC
AAGTCGATTCTTTAAGAAAAGTAAATACCAAAAGTTACTTTGGCGATGCAACTCGCCCTGATTTACTTCACACAGCAGGA
ATTGAGCACGCTGCCATGCTTGTTGTAGCTATTGATAATCAAGAAAGCAGTATAGAACTGGTTAAATACGTCAAGCACAC
GTATCCAAAAGTAAAAATACTCGCACGTGCTTTTGATAGAGGCCACTCATATATGCTTCGTTGTGCTGGTGCTGATTTCA
TTGAATCAGAAACCACCCGCTCAGCACTTGAAATGGGTGCTGAAGCCATGCGTAATCTAGGACAACACCCGTTTCATGTA
GAGCAACAAAAAATAGCATACAAAAAAGTAGAAAATCAAAGTTCAGATAAACTTTATCAAGCATGGTTAGACGATTCTGA
AGGTGAGCGTTTTGATAATAACTACCGTAAGCTTTTCATTGAATTAGAAGGAACGATTAAACACGCAATGAGTAAGGATC
GCTCAGATAAACACAATCAATCTGAACGAGCTTGGACTCCGCCACCAAAAGGTTATGCAGATGATATTGATGAATAA

Upstream 100 bases:

>100_bases
CTGTCCGCATTAATTGAAAATCGTGTTGATACTGAGGTAGCAAAAACGTTACCCAAACTAAACCACTCATTCGATAAATT
TATTAAGGAATAAAAGCATT

Downstream 100 bases:

>100_bases
AACCAACCTTTAATTAAATTAATAATGGTACTTATATTTTCATCTCATACTAAATCATAATATAAGTGCCATTTTCATTT
ATCTTAACACCTCATACACA

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MTGYFLQAFIYLVAAVIAVPIAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEFGVVMMLFLVGLELEPKMLWN
MRNRLMGLGGLQVVGTTAVVMGLAMFFGQSWTIALTIGLIFALSSTAIVLQTFNEKGLAKTEGGQNAFSVLLFQDIAVIP
MLAFIPLLALPELVAKAQLAAATAAEHHEELTLVAGLPGWAYGLVITASIALVVVGGHYLSRPLFRFVASSGLREIFTAT
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIDPFKGLLLGLFFITVGAGIDFGILFNDFFLIIGLTIG
VMVLKAAVLYILALIFKIKNSNRWLFTLSLAQAGEFGFVLLSFTVQNHVLPQEVAQPLSLVVALSMFFTPGLFILFDKVI
LPKFEQQSNERESDTIEEKGTVIIAGGGRFGQVVNRFLVSNHVNTVVLDHQADQVDSLRKVNTKSYFGDATRPDLLHTAG
IEHAAMLVVAIDNQESSIELVKYVKHTYPKVKILARAFDRGHSYMLRCAGADFIESETTRSALEMGAEAMRNLGQHPFHV
EQQKIAYKKVENQSSDKLYQAWLDDSEGERFDNNYRKLFIELEGTIKHAMSKDRSDKHNQSERAWTPPPKGYADDIDE

Sequences:

>Translated_638_residues
MTGYFLQAFIYLVAAVIAVPIAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEFGVVMMLFLVGLELEPKMLWN
MRNRLMGLGGLQVVGTTAVVMGLAMFFGQSWTIALTIGLIFALSSTAIVLQTFNEKGLAKTEGGQNAFSVLLFQDIAVIP
MLAFIPLLALPELVAKAQLAAATAAEHHEELTLVAGLPGWAYGLVITASIALVVVGGHYLSRPLFRFVASSGLREIFTAT
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIDPFKGLLLGLFFITVGAGIDFGILFNDFFLIIGLTIG
VMVLKAAVLYILALIFKIKNSNRWLFTLSLAQAGEFGFVLLSFTVQNHVLPQEVAQPLSLVVALSMFFTPGLFILFDKVI
LPKFEQQSNERESDTIEEKGTVIIAGGGRFGQVVNRFLVSNHVNTVVLDHQADQVDSLRKVNTKSYFGDATRPDLLHTAG
IEHAAMLVVAIDNQESSIELVKYVKHTYPKVKILARAFDRGHSYMLRCAGADFIESETTRSALEMGAEAMRNLGQHPFHV
EQQKIAYKKVENQSSDKLYQAWLDDSEGERFDNNYRKLFIELEGTIKHAMSKDRSDKHNQSERAWTPPPKGYADDIDE
>Mature_637_residues
TGYFLQAFIYLVAAVIAVPIAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEFGVVMMLFLVGLELEPKMLWNM
RNRLMGLGGLQVVGTTAVVMGLAMFFGQSWTIALTIGLIFALSSTAIVLQTFNEKGLAKTEGGQNAFSVLLFQDIAVIPM
LAFIPLLALPELVAKAQLAAATAAEHHEELTLVAGLPGWAYGLVITASIALVVVGGHYLSRPLFRFVASSGLREIFTATA
LMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIDPFKGLLLGLFFITVGAGIDFGILFNDFFLIIGLTIGV
MVLKAAVLYILALIFKIKNSNRWLFTLSLAQAGEFGFVLLSFTVQNHVLPQEVAQPLSLVVALSMFFTPGLFILFDKVIL
PKFEQQSNERESDTIEEKGTVIIAGGGRFGQVVNRFLVSNHVNTVVLDHQADQVDSLRKVNTKSYFGDATRPDLLHTAGI
EHAAMLVVAIDNQESSIELVKYVKHTYPKVKILARAFDRGHSYMLRCAGADFIESETTRSALEMGAEAMRNLGQHPFHVE
QQKIAYKKVENQSSDKLYQAWLDDSEGERFDNNYRKLFIELEGTIKHAMSKDRSDKHNQSERAWTPPPKGYADDIDE

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=411, Percent_Identity=26.5206812652068, Blast_Score=88, Evalue=3e-17,
Organism=Escherichia coli, GI1786232, Length=577, Percent_Identity=45.580589254766, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789749, Length=623, Percent_Identity=39.4863563402889, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1786685, Length=547, Percent_Identity=28.3363802559415, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 69788; Mature: 69657

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYFLQAFIYLVAAVIAVPIAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEF
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLVGLELEPKMLWNMRNRLMGLGGLQVVGTTAVVMGLAMFFGQSWTIALTIGLI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FALSSTAIVLQTFNEKGLAKTEGGQNAFSVLLFQDIAVIPMLAFIPLLALPELVAKAQLA
HHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AATAAEHHEELTLVAGLPGWAYGLVITASIALVVVGGHYLSRPLFRFVASSGLREIFTAT
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIDPFKGLLLGLFFITVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GIDFGILFNDFFLIIGLTIGVMVLKAAVLYILALIFKIKNSNRWLFTLSLAQAGEFGFVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEE
LSFTVQNHVLPQEVAQPLSLVVALSMFFTPGLFILFDKVILPKFEQQSNERESDTIEEKG
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCHHHHHHHCC
TVIIAGGGRFGQVVNRFLVSNHVNTVVLDHQADQVDSLRKVNTKSYFGDATRPDLLHTAG
EEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCHHHCCCCCCCCHHHHCC
IEHAAMLVVAIDNQESSIELVKYVKHTYPKVKILARAFDRGHSYMLRCAGADFIESETTR
CCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
SALEMGAEAMRNLGQHPFHVEQQKIAYKKVENQSSDKLYQAWLDDSEGERFDNNYRKLFI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCEEEEEE
ELEGTIKHAMSKDRSDKHNQSERAWTPPPKGYADDIDE
EEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGYFLQAFIYLVAAVIAVPIAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEF
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLVGLELEPKMLWNMRNRLMGLGGLQVVGTTAVVMGLAMFFGQSWTIALTIGLI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FALSSTAIVLQTFNEKGLAKTEGGQNAFSVLLFQDIAVIPMLAFIPLLALPELVAKAQLA
HHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AATAAEHHEELTLVAGLPGWAYGLVITASIALVVVGGHYLSRPLFRFVASSGLREIFTAT
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALMLVIGIAALMSLVGLSPALGTFLAGVVLANSEFRHELESNIDPFKGLLLGLFFITVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GIDFGILFNDFFLIIGLTIGVMVLKAAVLYILALIFKIKNSNRWLFTLSLAQAGEFGFVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEE
LSFTVQNHVLPQEVAQPLSLVVALSMFFTPGLFILFDKVILPKFEQQSNERESDTIEEKG
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCHHHHHHHCC
TVIIAGGGRFGQVVNRFLVSNHVNTVVLDHQADQVDSLRKVNTKSYFGDATRPDLLHTAG
EEEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCHHHCCCCCCCCHHHHCC
IEHAAMLVVAIDNQESSIELVKYVKHTYPKVKILARAFDRGHSYMLRCAGADFIESETTR
CCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
SALEMGAEAMRNLGQHPFHVEQQKIAYKKVENQSSDKLYQAWLDDSEGERFDNNYRKLFI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCEEEEEE
ELEGTIKHAMSKDRSDKHNQSERAWTPPPKGYADDIDE
EEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA