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The map label for this gene is uhpC [H]

Identifier: 59713222

GI number: 59713222

Start: 42109

End: 43449

Strand: Reverse

Name: uhpC [H]

Synonym: VF_A0039

Alternate gene names: 59713222

Gene position: 43449-42109 (Counterclockwise)

Preceding gene: 172087792

Following gene: 59713220

Centisome position: 3.27

GC content: 42.21

Gene sequence:

>1341_bases
ATGTTTGGATTTTTACGCTCAACCACATCAAATGACAACACACTTAGTGATACTCAAGTAAACGAAAGTTATCGCTATTG
GCGTTTACATATCATGATCGGCATGTACATTGGTTATGCTGGTTTTTACTTTACTCGTAAAACCTTTAACTATGCCGCTC
CTGCTATGATCACAGATTTAGGGCTTGATAAAGGTGATCTCGGTTTAATCGGCACTCTTTTCTATATCTCGTACGGCTTA
TCAAAATTTCTTTCAGGCACCATTTCTGATCGCTCTAACCCTCGTTATTTTATGGGGCTAGGATTAATTGCCACCGGACT
GATTAATATTGCTTTTGGCTTCTCTAGTTCATTAGCGGCTTTTATCTCTCTGTGGGTACTTAATGCATGGTTTCAAGGAT
GGGGTTGGCCTTCATGTTCAAAGCTCCTCACCACTTGGTACTCTCGATCTGAAAGAGGGTTCCGTTGGGCAATATGGAAC
ACAGCACACAACATCGGTGGAGCGCTAATCCCTATTCTTGTGGGCTATTTAACCCTTCATTACAGTTGGCGAGAAGGTTT
TATCTTACCGGGTATTATTGGTGTCGCAATTGGACTTATTGTATGTTGGCGTCTACGTGATAAACCCACCACCATGGGCT
TACCTAGTGTAGGAAAATGGCGTAATGATCCACTAGAGCTCGCACAAGAAAACCATGGCCAAGGATTAAGCTATCGAGAG
ATTTTAAAAACCTATGTGTTTAGTAATAAGTACATTTGGTTACTCGCTTTTAGCTATGTATTGGTTTACATCGTAAGAAC
CGCAGTCAATGACTGGGGAAACCTGTATCTCACAGAAGAACACAACTACAGCTTAATTAATGCAAATGCCGCATTATCCC
TATTTGAAATTGGCGGTTTTGTGGGCTCTCTTGTTGCTGGATGGGGTTCTGACAAGCTCTTTGGGGGCAATCGTGGACCT
ATGAATATTTTGTTCGCTATTGGTATTTTTCTTTCCGTTTCAGCGTTATGGCTTATGCCGTTAACCAATTTTGTGTTTCA
AGCTGCTGGGCTATTTTCTGTTGGTTTCTTTGTTTTTGGACCACAAATGTTAATTGGTATGGCTGCGGCTGAATGCTCAC
ACAAAGACTCGGCAGGCGCCGCTACAGGGTTTGTTGGATTATTTGCTTATATGGGGGCAGCGCTTTCAGGCTACCCATTA
GCGGTGATTTTAGAAACCTATGGATGGACAGGGTTCTTTATCACCATTTCGACTTGTGCTGCTGTCATAGGGTTACTGCT
TCTGCCCTTTTTACAAGCTCAATCACCTCAAAAACCGATTGAAACAAGAGTACGCTTATAA

Upstream 100 bases:

>100_bases
AGCGAGTTCAAGCACTCGGTGGGAAAATGGCCATCAATTCCAATACCTCGATTCCTGGCACTCAAATTAGCATTGCACTA
CCAAAAATGTGAGTATGACT

Downstream 100 bases:

>100_bases
CAGCAGTTATTTTCATTTCAAATATGAAGACGAAACGCTTACCCTACATTAGGGGCAATAATTAAAACAGCGATAATAGT
GGCAATTAATGTACGAGGAA

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFGFLRSTTSNDNTLSDTQVNESYRYWRLHIMIGMYIGYAGFYFTRKTFNYAAPAMITDLGLDKGDLGLIGTLFYISYGL
SKFLSGTISDRSNPRYFMGLGLIATGLINIAFGFSSSLAAFISLWVLNAWFQGWGWPSCSKLLTTWYSRSERGFRWAIWN
TAHNIGGALIPILVGYLTLHYSWREGFILPGIIGVAIGLIVCWRLRDKPTTMGLPSVGKWRNDPLELAQENHGQGLSYRE
ILKTYVFSNKYIWLLAFSYVLVYIVRTAVNDWGNLYLTEEHNYSLINANAALSLFEIGGFVGSLVAGWGSDKLFGGNRGP
MNILFAIGIFLSVSALWLMPLTNFVFQAAGLFSVGFFVFGPQMLIGMAAAECSHKDSAGAATGFVGLFAYMGAALSGYPL
AVILETYGWTGFFITISTCAAVIGLLLLPFLQAQSPQKPIETRVRL

Sequences:

>Translated_446_residues
MFGFLRSTTSNDNTLSDTQVNESYRYWRLHIMIGMYIGYAGFYFTRKTFNYAAPAMITDLGLDKGDLGLIGTLFYISYGL
SKFLSGTISDRSNPRYFMGLGLIATGLINIAFGFSSSLAAFISLWVLNAWFQGWGWPSCSKLLTTWYSRSERGFRWAIWN
TAHNIGGALIPILVGYLTLHYSWREGFILPGIIGVAIGLIVCWRLRDKPTTMGLPSVGKWRNDPLELAQENHGQGLSYRE
ILKTYVFSNKYIWLLAFSYVLVYIVRTAVNDWGNLYLTEEHNYSLINANAALSLFEIGGFVGSLVAGWGSDKLFGGNRGP
MNILFAIGIFLSVSALWLMPLTNFVFQAAGLFSVGFFVFGPQMLIGMAAAECSHKDSAGAATGFVGLFAYMGAALSGYPL
AVILETYGWTGFFITISTCAAVIGLLLLPFLQAQSPQKPIETRVRL
>Mature_446_residues
MFGFLRSTTSNDNTLSDTQVNESYRYWRLHIMIGMYIGYAGFYFTRKTFNYAAPAMITDLGLDKGDLGLIGTLFYISYGL
SKFLSGTISDRSNPRYFMGLGLIATGLINIAFGFSSSLAAFISLWVLNAWFQGWGWPSCSKLLTTWYSRSERGFRWAIWN
TAHNIGGALIPILVGYLTLHYSWREGFILPGIIGVAIGLIVCWRLRDKPTTMGLPSVGKWRNDPLELAQENHGQGLSYRE
ILKTYVFSNKYIWLLAFSYVLVYIVRTAVNDWGNLYLTEEHNYSLINANAALSLFEIGGFVGSLVAGWGSDKLFGGNRGP
MNILFAIGIFLSVSALWLMPLTNFVFQAAGLFSVGFFVFGPQMLIGMAAAECSHKDSAGAATGFVGLFAYMGAALSGYPL
AVILETYGWTGFFITISTCAAVIGLLLLPFLQAQSPQKPIETRVRL

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=421, Percent_Identity=33.729216152019, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4503847, Length=421, Percent_Identity=33.729216152019, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI256219483, Length=421, Percent_Identity=33.729216152019, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI256219543, Length=434, Percent_Identity=32.9493087557604, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI256219564, Length=350, Percent_Identity=32.2857142857143, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI46361976, Length=391, Percent_Identity=24.8081841432225, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI49619231, Length=391, Percent_Identity=25.5754475703325, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI223717983, Length=407, Percent_Identity=27.5184275184275, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38093649, Length=407, Percent_Identity=27.5184275184275, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI14150047, Length=162, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI87082310, Length=438, Percent_Identity=60.7305936073059, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1788573, Length=445, Percent_Identity=33.2584269662921, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI2367259, Length=431, Percent_Identity=31.0904872389791, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI2367379, Length=456, Percent_Identity=22.5877192982456, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789152, Length=425, Percent_Identity=24.7058823529412, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561094, Length=401, Percent_Identity=25.9351620947631, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI133930953, Length=465, Percent_Identity=22.5806451612903, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17542316, Length=437, Percent_Identity=21.2814645308924, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI133901854, Length=475, Percent_Identity=21.0526315789474, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI133901856, Length=475, Percent_Identity=21.0526315789474, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539138, Length=318, Percent_Identity=22.6415094339623, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656861, Length=472, Percent_Identity=24.364406779661, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656866, Length=472, Percent_Identity=24.364406779661, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550478, Length=472, Percent_Identity=24.364406779661, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49356; Mature: 49356

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGFLRSTTSNDNTLSDTQVNESYRYWRLHIMIGMYIGYAGFYFTRKTFNYAAPAMITDL
CCCCCCCCCCCCCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
GLDKGDLGLIGTLFYISYGLSKFLSGTISDRSNPRYFMGLGLIATGLINIAFGFSSSLAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHH
FISLWVLNAWFQGWGWPSCSKLLTTWYSRSERGFRWAIWNTAHNIGGALIPILVGYLTLH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHE
YSWREGFILPGIIGVAIGLIVCWRLRDKPTTMGLPSVGKWRNDPLELAQENHGQGLSYRE
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHH
ILKTYVFSNKYIWLLAFSYVLVYIVRTAVNDWGNLYLTEEHNYSLINANAALSLFEIGGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHHHHHHHH
VGSLVAGWGSDKLFGGNRGPMNILFAIGIFLSVSALWLMPLTNFVFQAAGLFSVGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKDSAGAATGFVGLFAYMGAALSGYPLAVILETYGWTGFFITISTCA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHHHH
AVIGLLLLPFLQAQSPQKPIETRVRL
HHHHHHHHHHHHCCCCCCCHHHCCCC
>Mature Secondary Structure
MFGFLRSTTSNDNTLSDTQVNESYRYWRLHIMIGMYIGYAGFYFTRKTFNYAAPAMITDL
CCCCCCCCCCCCCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
GLDKGDLGLIGTLFYISYGLSKFLSGTISDRSNPRYFMGLGLIATGLINIAFGFSSSLAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHH
FISLWVLNAWFQGWGWPSCSKLLTTWYSRSERGFRWAIWNTAHNIGGALIPILVGYLTLH
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHE
YSWREGFILPGIIGVAIGLIVCWRLRDKPTTMGLPSVGKWRNDPLELAQENHGQGLSYRE
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHH
ILKTYVFSNKYIWLLAFSYVLVYIVRTAVNDWGNLYLTEEHNYSLINANAALSLFEIGGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHHHHHHHH
VGSLVAGWGSDKLFGGNRGPMNILFAIGIFLSVSALWLMPLTNFVFQAAGLFSVGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKDSAGAATGFVGLFAYMGAALSGYPLAVILETYGWTGFFITISTCA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHHHH
AVIGLLLLPFLQAQSPQKPIETRVRL
HHHHHHHHHHHHCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]