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The map label for this gene is gor [H]

Identifier: 59713096

GI number: 59713096

Start: 2790267

End: 2791622

Strand: Direct

Name: gor [H]

Synonym: VF_2489

Alternate gene names: 59713096

Gene position: 2790267-2791622 (Clockwise)

Preceding gene: 59713095

Following gene: 59713097

Centisome position: 96.3

GC content: 43.58

Gene sequence:

>1356_bases
ATGACTACACATTTTGATTATATCTGTATTGGCGGTGGTTCAGGCGGTATCGCATCAGCAAACCGTGCATCAATGTACGG
TGCAAAAGTGGCACTGATCGAAGCTCAAGATCTTGGCGGTACGTGTGTAAACGTAGGGTGTGTACCTAAAAAAGTAATGT
GGCATGGCGCTCAAGTTGCTGAAGCCATTAATCTATACGCTGAAGATTACGGCTTTGATGTAGAGCTAAAAGAATTCAAA
TGGAACAAGATGATTGAAAGCCGCCAAGCTTACATTGGCCGCATTCATGAATCTTACGATCGCGTACTTGGTAATAACAA
AGTAAACGTAATCAAAGGCTTTGCTAAGTTTGTTGATGCAAAAACCGTTGAAGTAAACGGTGAGCACTACACAGCGGATC
ATATTCTTATTGCCGTTGGCGGTCGTCCAACAATTCCAAATATCCCTGGTGCAGAATACGGTATTGATTCAAACGGTTTC
TTTGAACTGACTGAACAACCAAAACGCGTTGCGGTTATTGGTGCAGGTTACATTGCAGTAGAAATCGCAGGCGTTCTTCA
TTCTCTAGGTACAGAAACTCACCTATTCTGCCGTAAAGAATCACCACTACGTAGCTTTGACCCAATGATCATCGATACGC
TAGTTGAAGTAATGAATACCGAAGGCCCAACACTTCATACTCACTCGGTACCAAAAGAAGTAGTTAAAGAAGCAGACGGC
AGCCTAACGCTTCACCTAGAAAACGGTAATACACAAAACGTTGATACGCTAATTTGGGCTATCGGTCGTCACCCAGCAAC
GGATGCTATCAATCTTGATAAAACCGGTGTTGCAACAAACGATCGCGGTTACATCAAAGTGGATGAATACCAAGAAACAA
ACGTGAAAGGCATCTACTGTGTTGGTGACATCATGGAAGGCGGTATTGAGCTGACTCCTGTTGCGGTTAAAGCAGGTCGT
CAACTTTCAGAGCGTCTATTTAATGGCAAAACCAATGCAAAAATGGACTACGATTTAGTTCCTACTGTTGTATTTAGCCA
CCCACCAATTGGTACGATTGGCTTAACAGAACAAGAAGCTGACGAACAATACGGCAAAGAGAACGTGAAAGTGTACACAT
CAGGCTTTACTGCAATGTACACAGCAGTAACTAAGCACCGTCAACCTTGTAAGATGAAGCTAGTCTGTGCGGGCGAAGAT
GAAAAAGTTGTTGGCCTACACGGTATCGGTTTCACGGTTGATGAAATGATCCAAGGTTTTGCAGTTGCAATGAAGATGGG
CGCAACTAAGGCTGATTTCGATGCCGTTGTGGCTATTCACCCAACAGGTTCAGAAGAATTTGTAACGATGCGATAG

Upstream 100 bases:

>100_bases
TCGCATTTCATACATAGTAAATAAAAAGAATTAATACCAATGTTATAAATTAGATGAAGATAATTATTAGAATTGGTTAA
CACTTATTGGAGAGAAAGTA

Downstream 100 bases:

>100_bases
TCTGATATTAGACTCTCTATTCTAACGATAAAAAACGGGATAATAACTATCCCGTTTTTTATTTTTACGAGATAGGTAAT
AATTCTTATCACCCGATATA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTTHFDYICIGGGSGGIASANRASMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVAEAINLYAEDYGFDVELKEFK
WNKMIESRQAYIGRIHESYDRVLGNNKVNVIKGFAKFVDAKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGF
FELTEQPKRVAVIGAGYIAVEIAGVLHSLGTETHLFCRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
SLTLHLENGNTQNVDTLIWAIGRHPATDAINLDKTGVATNDRGYIKVDEYQETNVKGIYCVGDIMEGGIELTPVAVKAGR
QLSERLFNGKTNAKMDYDLVPTVVFSHPPIGTIGLTEQEADEQYGKENVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGED
EKVVGLHGIGFTVDEMIQGFAVAMKMGATKADFDAVVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MTTHFDYICIGGGSGGIASANRASMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVAEAINLYAEDYGFDVELKEFK
WNKMIESRQAYIGRIHESYDRVLGNNKVNVIKGFAKFVDAKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGF
FELTEQPKRVAVIGAGYIAVEIAGVLHSLGTETHLFCRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
SLTLHLENGNTQNVDTLIWAIGRHPATDAINLDKTGVATNDRGYIKVDEYQETNVKGIYCVGDIMEGGIELTPVAVKAGR
QLSERLFNGKTNAKMDYDLVPTVVFSHPPIGTIGLTEQEADEQYGKENVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGED
EKVVGLHGIGFTVDEMIQGFAVAMKMGATKADFDAVVAIHPTGSEEFVTMR
>Mature_450_residues
TTHFDYICIGGGSGGIASANRASMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVAEAINLYAEDYGFDVELKEFKW
NKMIESRQAYIGRIHESYDRVLGNNKVNVIKGFAKFVDAKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGFF
ELTEQPKRVAVIGAGYIAVEIAGVLHSLGTETHLFCRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADGS
LTLHLENGNTQNVDTLIWAIGRHPATDAINLDKTGVATNDRGYIKVDEYQETNVKGIYCVGDIMEGGIELTPVAVKAGRQ
LSERLFNGKTNAKMDYDLVPTVVFSHPPIGTIGLTEQEADEQYGKENVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEDE
KVVGLHGIGFTVDEMIQGFAVAMKMGATKADFDAVVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=52.9284164859002, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=39.6514161220044, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=36.043956043956, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=36.043956043956, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=36.043956043956, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=36.043956043956, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=36.043956043956, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=33.8427947598253, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI291045268, Length=458, Percent_Identity=30.1310043668122, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=29.3736501079914, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=70.7317073170732, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=444, Percent_Identity=28.6036036036036, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082354, Length=432, Percent_Identity=26.6203703703704, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=25.2747252747253, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787114, Length=202, Percent_Identity=30.1980198019802, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71983419, Length=449, Percent_Identity=56.5701559020045, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71983429, Length=449, Percent_Identity=56.5701559020045, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=35.6540084388186, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=35.5509355509356, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI32565766, Length=475, Percent_Identity=30.3157894736842, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=50.4291845493562, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=26.7241379310345, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=23.7894736842105, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=39.6588486140725, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=39.6588486140725, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=39.6588486140725, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=37.3673036093418, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=29.3361884368308, Blast_Score=155, Evalue=8e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49055; Mature: 48924

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHFDYICIGGGSGGIASANRASMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVA
CCCEEEEEEEECCCCCCCCCCCCHHCCEEEEEEEECCCCCEEEEECCCCHHHHHCCHHHH
EAINLYAEDYGFDVELKEFKWNKMIESRQAYIGRIHESYDRVLGNNKVNVIKGFAKFVDA
HHHHHHHHHCCCCEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
KTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGFFELTEQPKRVAVIGAGYIAV
EEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EIAGVLHSLGTETHLFCRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCC
SLTLHLENGNTQNVDTLIWAIGRHPATDAINLDKTGVATNDRGYIKVDEYQETNVKGIYC
CEEEEECCCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEE
VGDIMEGGIELTPVAVKAGRQLSERLFNGKTNAKMDYDLVPTVVFSHPPIGTIGLTEQEA
EEEHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEECCCCCCEECCCHHHH
DEQYGKENVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEDEKVVGLHGIGFTVDEMIQGF
HHHCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHH
AVAMKMGATKADFDAVVAIHPTGSEEFVTMR
HHHHHCCCCCCCCCEEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TTHFDYICIGGGSGGIASANRASMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVA
CCEEEEEEEECCCCCCCCCCCCHHCCEEEEEEEECCCCCEEEEECCCCHHHHHCCHHHH
EAINLYAEDYGFDVELKEFKWNKMIESRQAYIGRIHESYDRVLGNNKVNVIKGFAKFVDA
HHHHHHHHHCCCCEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
KTVEVNGEHYTADHILIAVGGRPTIPNIPGAEYGIDSNGFFELTEQPKRVAVIGAGYIAV
EEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EIAGVLHSLGTETHLFCRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCC
SLTLHLENGNTQNVDTLIWAIGRHPATDAINLDKTGVATNDRGYIKVDEYQETNVKGIYC
CEEEEECCCCCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEE
VGDIMEGGIELTPVAVKAGRQLSERLFNGKTNAKMDYDLVPTVVFSHPPIGTIGLTEQEA
EEEHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEECCCCCCEECCCHHHH
DEQYGKENVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEDEKVVGLHGIGFTVDEMIQGF
HHHCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHH
AVAMKMGATKADFDAVVAIHPTGSEEFVTMR
HHHHHCCCCCCCCCEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]