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The map label for this gene is ubiA [H]

Identifier: 59713051

GI number: 59713051

Start: 2746171

End: 2747028

Strand: Reverse

Name: ubiA [H]

Synonym: VF_2444

Alternate gene names: 59713051

Gene position: 2747028-2746171 (Counterclockwise)

Preceding gene: 59713052

Following gene: 59713049

Centisome position: 94.81

GC content: 39.63

Gene sequence:

>858_bases
ATGAACATGTCAAAAGCAGAGGCGTTTTGGCAACTGACCCGAATGAATCGTCCAATTGGTTCTCTATTACTTTTATGGCC
AACATTGTGGGCTTTATTTTTAGCAGCCGATGGATTACCTGATTGGCATGTACTGATTGTATTTGTATTAGGTGTGGTTT
TTATGCGCTCTGCGGGGTGCGTGATTAATGATTTTGCGGACCGTAAAGTGGATGGTCATGTAAAACGAACGGCTAATCGT
CCATTGCCTTCTGGACTTATCTCTTCAAAAGAAGCGTTGTCTCTTTTTGCTGTTTTGGTTGTGTGTTCTTTTCTTCTTGT
TTTAACCATGAACACCTTAACCATTATGCTATCGGGTATCGGTATTGTTCTTGCCATAGCTTACCCTTTTATGAAACGAG
TGACGTATCTCCCTCAGTTTGTACTTGGACTAGCATTTAGCTGGGCAATTCCAATGGCATACGCAGCAGAATCAAATCAG
GTACCACCTGAAGCGTGGTTACTGTTTGTGATTAATGCATTGTGGACGATCGCCTACGATACACAGTATGCAATGGTGGA
CAGAGATGATGATGTAAAGATTGGTATTAAATCAACAGCCATTTTGTTTGGACGCTATGATAAAACGATTATCGGTTTAT
TGCAGTTATCGGTATTGGCATTATTGATCGTATTAGGCTCTCAATTAGCGCTTTCTGGTATTTATTATTGGGGAATATTA
GCGGCTGCTGGATTTTTTGTGTATCAGCAATGGTTAATAAAAGGACGTGAAAGGGAAGCTTGCTTTAAAGCGTTTTTAAA
TAATAACTATGTCGGTGGACTGATTTTTATTGCTATCAGTGCAAGCGTTTTAATTTAA

Upstream 100 bases:

>100_bases
TGTTTGCTCGTCGTTCTCGATTATGGATGAATAATAAACCTATGCTAGTTGCAGAGTTATTTTTACCAGAAGCACCCATT
TATTCAAAGGAAGTGGAATC

Downstream 100 bases:

>100_bases
CGTGTTGTTTTAAAAGAAAAGCCAGTATGACTAATATCATACTGGCTTTTTTTGTATTTAAAGAAAGGGACGTTAAATTA
GTCTTCTTTTGTCATTACTG

Product: 4-hydroxybenzoate octaprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNMSKAEAFWQLTRMNRPIGSLLLLWPTLWALFLAADGLPDWHVLIVFVLGVVFMRSAGCVINDFADRKVDGHVKRTANR
PLPSGLISSKEALSLFAVLVVCSFLLVLTMNTLTIMLSGIGIVLAIAYPFMKRVTYLPQFVLGLAFSWAIPMAYAAESNQ
VPPEAWLLFVINALWTIAYDTQYAMVDRDDDVKIGIKSTAILFGRYDKTIIGLLQLSVLALLIVLGSQLALSGIYYWGIL
AAAGFFVYQQWLIKGREREACFKAFLNNNYVGGLIFIAISASVLI

Sequences:

>Translated_285_residues
MNMSKAEAFWQLTRMNRPIGSLLLLWPTLWALFLAADGLPDWHVLIVFVLGVVFMRSAGCVINDFADRKVDGHVKRTANR
PLPSGLISSKEALSLFAVLVVCSFLLVLTMNTLTIMLSGIGIVLAIAYPFMKRVTYLPQFVLGLAFSWAIPMAYAAESNQ
VPPEAWLLFVINALWTIAYDTQYAMVDRDDDVKIGIKSTAILFGRYDKTIIGLLQLSVLALLIVLGSQLALSGIYYWGIL
AAAGFFVYQQWLIKGREREACFKAFLNNNYVGGLIFIAISASVLI
>Mature_285_residues
MNMSKAEAFWQLTRMNRPIGSLLLLWPTLWALFLAADGLPDWHVLIVFVLGVVFMRSAGCVINDFADRKVDGHVKRTANR
PLPSGLISSKEALSLFAVLVVCSFLLVLTMNTLTIMLSGIGIVLAIAYPFMKRVTYLPQFVLGLAFSWAIPMAYAAESNQ
VPPEAWLLFVINALWTIAYDTQYAMVDRDDDVKIGIKSTAILFGRYDKTIIGLLQLSVLALLIVLGSQLALSGIYYWGIL
AAAGFFVYQQWLIKGREREACFKAFLNNNYVGGLIFIAISASVLI

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=276, Percent_Identity=34.4202898550725, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1790473, Length=282, Percent_Identity=64.1843971631206, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1786631, Length=187, Percent_Identity=26.2032085561497, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17553718, Length=278, Percent_Identity=35.6115107913669, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32565247, Length=282, Percent_Identity=34.0425531914894, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17553720, Length=335, Percent_Identity=28.0597014925373, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565245, Length=139, Percent_Identity=41.726618705036, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32565243, Length=138, Percent_Identity=41.304347826087, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=277, Percent_Identity=34.6570397111913, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI21355567, Length=280, Percent_Identity=37.5, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 31611; Mature: 31611

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSKAEAFWQLTRMNRPIGSLLLLWPTLWALFLAADGLPDWHVLIVFVLGVVFMRSAGC
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VINDFADRKVDGHVKRTANRPLPSGLISSKEALSLFAVLVVCSFLLVLTMNTLTIMLSGI
EEEHHHCCCCCCHHHHHCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVLAIAYPFMKRVTYLPQFVLGLAFSWAIPMAYAAESNQVPPEAWLLFVINALWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
TQYAMVDRDDDVKIGIKSTAILFGRYDKTIIGLLQLSVLALLIVLGSQLALSGIYYWGIL
CEEEEECCCCCCEEEEEHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAAGFFVYQQWLIKGREREACFKAFLNNNYVGGLIFIAISASVLI
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNMSKAEAFWQLTRMNRPIGSLLLLWPTLWALFLAADGLPDWHVLIVFVLGVVFMRSAGC
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VINDFADRKVDGHVKRTANRPLPSGLISSKEALSLFAVLVVCSFLLVLTMNTLTIMLSGI
EEEHHHCCCCCCHHHHHCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVLAIAYPFMKRVTYLPQFVLGLAFSWAIPMAYAAESNQVPPEAWLLFVINALWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
TQYAMVDRDDDVKIGIKSTAILFGRYDKTIIGLLQLSVLALLIVLGSQLALSGIYYWGIL
CEEEEECCCCCCEEEEEHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAAGFFVYQQWLIKGREREACFKAFLNNNYVGGLIFIAISASVLI
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA