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The map label for this gene is arsR [H]

Identifier: 59712968

GI number: 59712968

Start: 2649539

End: 2649868

Strand: Reverse

Name: arsR [H]

Synonym: VF_2361

Alternate gene names: 59712968

Gene position: 2649868-2649539 (Counterclockwise)

Preceding gene: 59712970

Following gene: 59712967

Centisome position: 91.45

GC content: 38.79

Gene sequence:

>330_bases
ATGTTACCTCATCAATTTTTCAAAATGTTATCAGATGAAACGCGAATGCGTTGTTTATTGCTTATTGCTCGTGAAGGTCG
CTTGTGCGTAAACCAATTAACGGAAGCGCTAGATGAAAGTCAGCCTAAGATTTCACGTCATTTAGCTCAGTTGCGTCAAT
CTGGTGTGTTGGTTGATACCCGTGAAGGTCAGTGGGTGTATTACCAAGTTAGTTCAAATTTACCGGGTTGGCTAAATAAA
ATTATAGAGGGTTTGAAGCAATCGAATTGTTTGCAGGCTCAATATCAAAAAGACACTGATAAATTAAACGCAATGAAAGC
GTGCTGTTAA

Upstream 100 bases:

>100_bases
TTTATTCAACAGCTTGTGTATTAAATTGATTTTTTCCTTGATTTGCATTTTCTTATTGCTAATATATGGAAATGCATATA
TCCATATTTAAGGGCTGAGT

Downstream 100 bases:

>100_bases
AGGATAATTAAGATGAAAATTAAAGTAGGTATTAACGGATTTGGTCGTATTGGACGTTTGGCGCTAAGAGCCGCATTTGA
TTGGCCTGAACTTGAATTTG

Product: DNA-binding transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MLPHQFFKMLSDETRMRCLLLIAREGRLCVNQLTEALDESQPKISRHLAQLRQSGVLVDTREGQWVYYQVSSNLPGWLNK
IIEGLKQSNCLQAQYQKDTDKLNAMKACC

Sequences:

>Translated_109_residues
MLPHQFFKMLSDETRMRCLLLIAREGRLCVNQLTEALDESQPKISRHLAQLRQSGVLVDTREGQWVYYQVSSNLPGWLNK
IIEGLKQSNCLQAQYQKDTDKLNAMKACC
>Mature_109_residues
MLPHQFFKMLSDETRMRCLLLIAREGRLCVNQLTEALDESQPKISRHLAQLRQSGVLVDTREGQWVYYQVSSNLPGWLNK
IIEGLKQSNCLQAQYQKDTDKLNAMKACC

Specific function: Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arse

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789916, Length=83, Percent_Identity=55.421686746988, Blast_Score=102, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 12586; Mature: 12586

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPHQFFKMLSDETRMRCLLLIAREGRLCVNQLTEALDESQPKISRHLAQLRQSGVLVDT
CCHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEC
REGQWVYYQVSSNLPGWLNKIIEGLKQSNCLQAQYQKDTDKLNAMKACC
CCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPHQFFKMLSDETRMRCLLLIAREGRLCVNQLTEALDESQPKISRHLAQLRQSGVLVDT
CCHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEC
REGQWVYYQVSSNLPGWLNKIIEGLKQSNCLQAQYQKDTDKLNAMKACC
CCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721697; 8041620; 9278503 [H]