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The map label for this gene is dipZ [H]

Identifier: 59712963

GI number: 59712963

Start: 2643857

End: 2645704

Strand: Direct

Name: dipZ [H]

Synonym: VF_2356

Alternate gene names: 59712963

Gene position: 2643857-2645704 (Clockwise)

Preceding gene: 59712961

Following gene: 59712964

Centisome position: 91.25

GC content: 39.66

Gene sequence:

>1848_bases
ATGACGCATTTATACCGCTTTCGAACAGCCCTTTTATCTCTCTTTCTTTTGTTCACAACTTTGGTTCCTAACGCTAATGC
TGCGTTTGATTTAACCAAACTTCAAGGAAGCCAAGATTCATCTTTTGTGACAGTAAATGAGGCTTTTCCTTTCAATTTTA
TGCAACAAGGCGATCGTGTTTATTTAGATTGGCAAGTAAAACCTGATTATTATCTGTATCAACAACGCATCTCAGTAAAA
GCGAACAGTGCCGAAATTGCAGATCTCGTAATGGAAGATGGAACCCCTCATAATGATGAGTTTTTTGGTGATGTGAATAT
CTACACCGAGCCACTAACCATTACTGTTCCACTGGTTTCAGTCGGTGATAACGCAGAATTAATTGTTCGATACCAAGGTT
GTGCAAAAGCTGGATTTTGCTATCCACCTGAAATTCGTAAAATTCCACTATCAGAGCTAAGCGCTCCAAGTAGCTATCAA
AATGAAGTAGCAAAAACAGACGTGGTTGCCAAAAGTGAAAATGCACCGGTTGGAATAAAAACATCAGTTCAGCCAACACC
TGAAACACCAAAAACGCAAACTCAACAACAAGAGTTAGCGACCAATTTAGGTGATGCTTGGTGGACACCTTTCTTATTTC
TAGCATTAGGTATTGGTCTTGCGTTTACGCCTTGCGTACTGCCTATGTACCCTATCTTAACGGGAATTGTTTTAGGTGGC
GGTAAATTGCCTCATGGTAAGGCATTTAAACTCTCTTTTGTTTACGTTCAAGGCATGGCATTAACCTATACCCTACTTGG
ATTAGTGGTTGCTTCAGCTGGTCTTCAGTTCCAAGCGGCATTACAACACCCTTATGTACTTATTGGATTAAGCATTCTAT
TTGTATTACTTGCTCTTTCTATGTTTGGGGCTTACACCATTCAACTACCAAGCAGCATACAGACCAAATTAAATGACATC
AGCAATCAGCAGCAAGGTGGTAACTTAGGTGGCGTATTTGCCATGGGGGCTATCTCAGGCTTAGTTTGTTCTCCATGTAC
AACGGCACCACTCTCTGGCGCCCTGCTTTATGTAGCAAAAAGTGGAGACTTACTAACAGGGGCTATTGCCCTTTATGCTC
TGGCTATTGGTATGGGTATTCCACTGATCTTGGCGGCGGTATTTGGCAATAAATTACTACCAAAAGCCGGTGTTTGGATG
ACGCATGTAAAAACACTATTTGGTTTTATTTTACTTGCCGTTCCTGTGTTTTTATTAGAGCGAATTCTTCCACATGACAT
CACCCCATTTGTTTGGTCTGCGTTAGGTATTGCTGCATTTGGTTGGTTATATCATGTTAAAGCAACCATGCCTCAGTCAT
GGAAGACCAGTATTGTTGGCATTGTGGCCATTTTAGGTATTGTTGGTTCAGCTATTCCGGTAATTGATGCGATTTCTGGA
AAAAGCAATACAGAGATAACAACAAAAACTCAAACTGTGACCTTTAAAAAAATCACTAATATTAATGAGTTAAACCAAGA
ACTAGAAATAGCCAAAGCACAAGGAAAACCAGTCATGCTCGACTTTTATGCTGATTGGTGTGTTGCGTGTAAAGAATTTG
AAAAGTACACCTTCCATAATGAGAAAGTTGAGCCTGTATTATCTGAGTTTGTTTTATTACAAGCAGACGTAACAAAGAAC
AGTCCAACGGATATTGAGCTATTACAGCAGCTAAAAGTTCTTGGGCTACCAACTATCGATTTTTGGAATGCCAACGGAGA
ATATTTATCTGATTCCCGTTTAACTGGTTTTATGAAAGCCGATCCATTTATGGATCATTTAAGTACAAACGTGATCAATG
TTAAATAA

Upstream 100 bases:

>100_bases
GAAGAGATAGATATAAAATCGTGCGAATTGATACTATACTTGTCGAACTCTTGACCGTTTCTATAGTCATACCCGTACCT
ATATTTATAAAGATTTTCAC

Downstream 100 bases:

>100_bases
TAATGTTTCTTTATTGAGCAAAATCATTGGTGATACGTGATAACTTATTTTATAATGCGAATTAATGATTTTTGATTCTA
CGACTTACGTTTTTTTTGAG

Product: thiol:disulfide interchange protein precursor

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MTHLYRFRTALLSLFLLFTTLVPNANAAFDLTKLQGSQDSSFVTVNEAFPFNFMQQGDRVYLDWQVKPDYYLYQQRISVK
ANSAEIADLVMEDGTPHNDEFFGDVNIYTEPLTITVPLVSVGDNAELIVRYQGCAKAGFCYPPEIRKIPLSELSAPSSYQ
NEVAKTDVVAKSENAPVGIKTSVQPTPETPKTQTQQQELATNLGDAWWTPFLFLALGIGLAFTPCVLPMYPILTGIVLGG
GKLPHGKAFKLSFVYVQGMALTYTLLGLVVASAGLQFQAALQHPYVLIGLSILFVLLALSMFGAYTIQLPSSIQTKLNDI
SNQQQGGNLGGVFAMGAISGLVCSPCTTAPLSGALLYVAKSGDLLTGAIALYALAIGMGIPLILAAVFGNKLLPKAGVWM
THVKTLFGFILLAVPVFLLERILPHDITPFVWSALGIAAFGWLYHVKATMPQSWKTSIVGIVAILGIVGSAIPVIDAISG
KSNTEITTKTQTVTFKKITNINELNQELEIAKAQGKPVMLDFYADWCVACKEFEKYTFHNEKVEPVLSEFVLLQADVTKN
SPTDIELLQQLKVLGLPTIDFWNANGEYLSDSRLTGFMKADPFMDHLSTNVINVK

Sequences:

>Translated_615_residues
MTHLYRFRTALLSLFLLFTTLVPNANAAFDLTKLQGSQDSSFVTVNEAFPFNFMQQGDRVYLDWQVKPDYYLYQQRISVK
ANSAEIADLVMEDGTPHNDEFFGDVNIYTEPLTITVPLVSVGDNAELIVRYQGCAKAGFCYPPEIRKIPLSELSAPSSYQ
NEVAKTDVVAKSENAPVGIKTSVQPTPETPKTQTQQQELATNLGDAWWTPFLFLALGIGLAFTPCVLPMYPILTGIVLGG
GKLPHGKAFKLSFVYVQGMALTYTLLGLVVASAGLQFQAALQHPYVLIGLSILFVLLALSMFGAYTIQLPSSIQTKLNDI
SNQQQGGNLGGVFAMGAISGLVCSPCTTAPLSGALLYVAKSGDLLTGAIALYALAIGMGIPLILAAVFGNKLLPKAGVWM
THVKTLFGFILLAVPVFLLERILPHDITPFVWSALGIAAFGWLYHVKATMPQSWKTSIVGIVAILGIVGSAIPVIDAISG
KSNTEITTKTQTVTFKKITNINELNQELEIAKAQGKPVMLDFYADWCVACKEFEKYTFHNEKVEPVLSEFVLLQADVTKN
SPTDIELLQQLKVLGLPTIDFWNANGEYLSDSRLTGFMKADPFMDHLSTNVINVK
>Mature_614_residues
THLYRFRTALLSLFLLFTTLVPNANAAFDLTKLQGSQDSSFVTVNEAFPFNFMQQGDRVYLDWQVKPDYYLYQQRISVKA
NSAEIADLVMEDGTPHNDEFFGDVNIYTEPLTITVPLVSVGDNAELIVRYQGCAKAGFCYPPEIRKIPLSELSAPSSYQN
EVAKTDVVAKSENAPVGIKTSVQPTPETPKTQTQQQELATNLGDAWWTPFLFLALGIGLAFTPCVLPMYPILTGIVLGGG
KLPHGKAFKLSFVYVQGMALTYTLLGLVVASAGLQFQAALQHPYVLIGLSILFVLLALSMFGAYTIQLPSSIQTKLNDIS
NQQQGGNLGGVFAMGAISGLVCSPCTTAPLSGALLYVAKSGDLLTGAIALYALAIGMGIPLILAAVFGNKLLPKAGVWMT
HVKTLFGFILLAVPVFLLERILPHDITPFVWSALGIAAFGWLYHVKATMPQSWKTSIVGIVAILGIVGSAIPVIDAISGK
SNTEITTKTQTVTFKKITNINELNQELEIAKAQGKPVMLDFYADWCVACKEFEKYTFHNEKVEPVLSEFVLLQADVTKNS
PTDIELLQQLKVLGLPTIDFWNANGEYLSDSRLTGFMKADPFMDHLSTNVINVK

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=571, Percent_Identity=50.7880910683012, Blast_Score=553, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 67032; Mature: 66900

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLYRFRTALLSLFLLFTTLVPNANAAFDLTKLQGSQDSSFVTVNEAFPFNFMQQGDRV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCCCCEEEEECCCCCHHHCCCCEE
YLDWQVKPDYYLYQQRISVKANSAEIADLVMEDGTPHNDEFFGDVNIYTEPLTITVPLVS
EEEEEECCCHHEEHHHHEEECCCHHHHHHHHCCCCCCCCCEEECEEEEECCEEEEEEEEE
VGDNAELIVRYQGCAKAGFCYPPEIRKIPLSELSAPSSYQNEVAKTDVVAKSENAPVGIK
ECCCCEEEEEEECCCCCCCCCCCHHCCCCHHHCCCCCHHHHHHHHHHHEECCCCCCCCEE
TSVQPTPETPKTQTQQQELATNLGDAWWTPFLFLALGIGLAFTPCVLPMYPILTGIVLGG
ECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKLPHGKAFKLSFVYVQGMALTYTLLGLVVASAGLQFQAALQHPYVLIGLSILFVLLALS
CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHHHHHHHH
MFGAYTIQLPSSIQTKLNDISNQQQGGNLGGVFAMGAISGLVCSPCTTAPLSGALLYVAK
HHCEEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
SGDLLTGAIALYALAIGMGIPLILAAVFGNKLLPKAGVWMTHVKTLFGFILLAVPVFLLE
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RILPHDITPFVWSALGIAAFGWLYHVKATMPQSWKTSIVGIVAILGIVGSAIPVIDAISG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCC
KSNTEITTKTQTVTFKKITNINELNQELEIAKAQGKPVMLDFYADWCVACKEFEKYTFHN
CCCCEEEEEEEEEEHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCC
EKVEPVLSEFVLLQADVTKNSPTDIELLQQLKVLGLPTIDFWNANGEYLSDSRLTGFMKA
CHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCEEEEC
DPFMDHLSTNVINVK
CHHHHHHCCCEEECC
>Mature Secondary Structure 
THLYRFRTALLSLFLLFTTLVPNANAAFDLTKLQGSQDSSFVTVNEAFPFNFMQQGDRV
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCCCCEEEEECCCCCHHHCCCCEE
YLDWQVKPDYYLYQQRISVKANSAEIADLVMEDGTPHNDEFFGDVNIYTEPLTITVPLVS
EEEEEECCCHHEEHHHHEEECCCHHHHHHHHCCCCCCCCCEEECEEEEECCEEEEEEEEE
VGDNAELIVRYQGCAKAGFCYPPEIRKIPLSELSAPSSYQNEVAKTDVVAKSENAPVGIK
ECCCCEEEEEEECCCCCCCCCCCHHCCCCHHHCCCCCHHHHHHHHHHHEECCCCCCCCEE
TSVQPTPETPKTQTQQQELATNLGDAWWTPFLFLALGIGLAFTPCVLPMYPILTGIVLGG
ECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKLPHGKAFKLSFVYVQGMALTYTLLGLVVASAGLQFQAALQHPYVLIGLSILFVLLALS
CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHHHHHHHH
MFGAYTIQLPSSIQTKLNDISNQQQGGNLGGVFAMGAISGLVCSPCTTAPLSGALLYVAK
HHCEEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
SGDLLTGAIALYALAIGMGIPLILAAVFGNKLLPKAGVWMTHVKTLFGFILLAVPVFLLE
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RILPHDITPFVWSALGIAAFGWLYHVKATMPQSWKTSIVGIVAILGIVGSAIPVIDAISG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCC
KSNTEITTKTQTVTFKKITNINELNQELEIAKAQGKPVMLDFYADWCVACKEFEKYTFHN
CCCCEEEEEEEEEEHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCC
EKVEPVLSEFVLLQADVTKNSPTDIELLQQLKVLGLPTIDFWNANGEYLSDSRLTGFMKA
CHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCEEEEC
DPFMDHLSTNVINVK
CHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]