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The map label for this gene is orn

Identifier: 59712936

GI number: 59712936

Start: 2618730

End: 2619275

Strand: Reverse

Name: orn

Synonym: VF_2329

Alternate gene names: 59712936

Gene position: 2619275-2618730 (Counterclockwise)

Preceding gene: 59712940

Following gene: 59712934

Centisome position: 90.4

GC content: 37.18

Gene sequence:

>546_bases
ATGGCAATTAATGATCAAAACCTGATTTGGGTGGATTTAGAGATGACAGGATTGGATCCTGAAACTCATAAAATCATCGA
AATTGCATCTATTGTGACAGATGCACAACTGAATATTTTAGCAGAAGGTCCAGTAATTGCGATCCATCAGCCAGAAGAAG
AGTTGGCTAAAATGGACAATTGGTGTACCAATACTCATACAAATAGCGGATTAGTCGCTCGAGTACAAGAAAGTAAATAC
GATGAAGAAGCGGCAATTGCAGAAACTATTGCTTTCCTTGAGCAATGGGTTCCAAAAGGCGTATCACCAATTTGTGGTAA
TAGTATTGGACAAGATCGTCGTTTTTTATATAAGCACATGCCAAGATTAGAAGAGTATTTTCATTACCGCTATGTTGATG
TAAGTACAATTAAAGAGCTAGCTCGTCGATGGAAACCTGAAGTTTTAGATGGTTTTACCAAAGCAGGCACACATTTAGCG
TTAGATGATATTCGCGAATCTATTGCAGAATTGAAGTATTATCGCCAACATATTTTCACAATTTAA

Upstream 100 bases:

>100_bases
ACGAAATTAATTCACTTGTTGGTTGGCTTTCAGTTTTATGTTGAAAGATAAATCGGCCCGAGTATCATACCCTTTTTAGT
TACAAAATAGGCAACTCTCT

Downstream 100 bases:

>100_bases
TTTCATTTGATGATTTGTTGAGCGGAAAAACGCGATTTTGAAAAAAAATCGCATTTTTTTTCAAAATACGCTTGCATCAT
CACAGTTTACTCGTATAATT

Product: oligoribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MAINDQNLIWVDLEMTGLDPETHKIIEIASIVTDAQLNILAEGPVIAIHQPEEELAKMDNWCTNTHTNSGLVARVQESKY
DEEAAIAETIAFLEQWVPKGVSPICGNSIGQDRRFLYKHMPRLEEYFHYRYVDVSTIKELARRWKPEVLDGFTKAGTHLA
LDDIRESIAELKYYRQHIFTI

Sequences:

>Translated_181_residues
MAINDQNLIWVDLEMTGLDPETHKIIEIASIVTDAQLNILAEGPVIAIHQPEEELAKMDNWCTNTHTNSGLVARVQESKY
DEEAAIAETIAFLEQWVPKGVSPICGNSIGQDRRFLYKHMPRLEEYFHYRYVDVSTIKELARRWKPEVLDGFTKAGTHLA
LDDIRESIAELKYYRQHIFTI
>Mature_180_residues
AINDQNLIWVDLEMTGLDPETHKIIEIASIVTDAQLNILAEGPVIAIHQPEEELAKMDNWCTNTHTNSGLVARVQESKYD
EEAAIAETIAFLEQWVPKGVSPICGNSIGQDRRFLYKHMPRLEEYFHYRYVDVSTIKELARRWKPEVLDGFTKAGTHLAL
DDIRESIAELKYYRQHIFTI

Specific function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides

COG id: COG1949

COG function: function code A; Oligoribonuclease (3'->5' exoribonuclease)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain

Homologues:

Organism=Homo sapiens, GI224496106, Length=175, Percent_Identity=50.8571428571429, Blast_Score=187, Evalue=6e-48,
Organism=Escherichia coli, GI87082382, Length=181, Percent_Identity=69.060773480663, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17557752, Length=175, Percent_Identity=51.4285714285714, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323088, Length=181, Percent_Identity=38.121546961326, Blast_Score=118, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21355135, Length=176, Percent_Identity=50, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ORN_VIBF1 (Q5E2C2)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205712.1
- ProteinModelPortal:   Q5E2C2
- SMR:   Q5E2C2
- STRING:   Q5E2C2
- GeneID:   3277738
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2329
- NMPDR:   fig|312309.3.peg.2329
- eggNOG:   COG1949
- HOGENOM:   HBG448545
- OMA:   WNKGTHG
- PhylomeDB:   Q5E2C2
- ProtClustDB:   PRK05359
- BioCyc:   VFIS312309:VF2329-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00045
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR022894
- InterPro:   IPR012337
- SMART:   SM00479

Pfam domain/function: PF00929 Exonuc_X-T; SSF53098 RNaseH_fold

EC number: 3.1.-.- [C]

Molecular weight: Translated: 20827; Mature: 20696

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINDQNLIWVDLEMTGLDPETHKIIEIASIVTDAQLNILAEGPVIAIHQPEEELAKMDN
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEECCCEEEEECCHHHHHHHHH
WCTNTHTNSGLVARVQESKYDEEAAIAETIAFLEQWVPKGVSPICGNSIGQDRRFLYKHM
HHCCCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
PRLEEYFHYRYVDVSTIKELARRWKPEVLDGFTKAGTHLALDDIRESIAELKYYRQHIFT
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
I
C
>Mature Secondary Structure 
AINDQNLIWVDLEMTGLDPETHKIIEIASIVTDAQLNILAEGPVIAIHQPEEELAKMDN
CCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHEEEECCCEEEEECCHHHHHHHHH
WCTNTHTNSGLVARVQESKYDEEAAIAETIAFLEQWVPKGVSPICGNSIGQDRRFLYKHM
HHCCCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
PRLEEYFHYRYVDVSTIKELARRWKPEVLDGFTKAGTHLALDDIRESIAELKYYRQHIFT
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA