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The map label for this gene is grxC [C]

Identifier: 59712907

GI number: 59712907

Start: 2583847

End: 2584575

Strand: Direct

Name: grxC [C]

Synonym: VF_2300

Alternate gene names: 59712907

Gene position: 2583847-2584575 (Clockwise)

Preceding gene: 59712905

Following gene: 59712908

Centisome position: 89.17

GC content: 41.15

Gene sequence:

>729_bases
ATGTTTACATCTAAAGAAGGTCAATCAGTTCCTCAAGTAACTTTCCCTACTCGTCAAGGTGATGCTTGGGTTAACGTAAC
AACAGAAGAACTATTTAAAGACAAAACAGTTATCGTATTCAGTCTTCCTGGTGCTTTTACACCAACATGTTCTTCAAGCC
ACCTACCTCGCTACAACGAGTTACACTCTGTATTTAAAGAGAATGGCGTTGATGACATCCTATGTGTATCAGTAAACGAT
ACTTTCGTAATGAACGCATGGAAAGCAGACCAAGAAGCAGAAAACATCACTTTCATCCCTGATGGTAATGGTGAATTCAC
AGACGGCATGGGTATGCTAGTTGAGAAAAACGACCTTGGTTTTGGTAAACGTTCATGGCGTTACAGCATGCTAGTTAAAA
ATGGCGTAGTTGAAAAAATGTTCATCGAAGAAGACGTACCAGGCGACCCGTTCAAAGTATCTGATGCAGACACTATGCTA
AACTACCTTGCTCCTGAACATAAAGAACAAGAGTCAATTACAGTATTCACAAAACCAGGTTGTCCTTTCTGTATGAAAGC
GAAACAAAACCTAATCGACAAAGGCCTAAACTACGAAGAAGTGGTACTAGGTAAAGATGCAACCACAGTAAGTCTACGAG
CTATCACTGGTCGCACTACGGTTCCTCAAGTATTCATCGGCGGTAAACACATCGGTGGTAGCGAAGAACTAGAAGCTTTC
CTAGCTTAA

Upstream 100 bases:

>100_bases
AACGATTAGAACTATCAAGTCAGCTTTTGCATAATAGCTACATCAAACGGGCAGGCCCCGAAAAAGAAATTCAAAATTAT
TTAAATTAAAGGACATCATT

Downstream 100 bases:

>100_bases
TCGTTAACTTAACCGTTAATGAAAAGTAGCCCACAAACCGTGGGCTACCATTTCAAACTCTTCTTCTAAAATAAATCTAC
GTGAGATATGAATTATGAAA

Product: glutaredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFTSKEGQSVPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNELHSVFKENGVDDILCVSVND
TFVMNAWKADQEAENITFIPDGNGEFTDGMGMLVEKNDLGFGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTML
NYLAPEHKEQESITVFTKPGCPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAITGRTTVPQVFIGGKHIGGSEELEAF
LA

Sequences:

>Translated_242_residues
MFTSKEGQSVPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNELHSVFKENGVDDILCVSVND
TFVMNAWKADQEAENITFIPDGNGEFTDGMGMLVEKNDLGFGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTML
NYLAPEHKEQESITVFTKPGCPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAITGRTTVPQVFIGGKHIGGSEELEAF
LA
>Mature_242_residues
MFTSKEGQSVPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNELHSVFKENGVDDILCVSVND
TFVMNAWKADQEAENITFIPDGNGEFTDGMGMLVEKNDLGFGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTML
NYLAPEHKEQESITVFTKPGCPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAITGRTTVPQVFIGGKHIGGSEELEAF
LA

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=151, Percent_Identity=35.7615894039735, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1790039, Length=72, Percent_Identity=40.2777777777778, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323138, Length=137, Percent_Identity=32.8467153284672, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI78706776, Length=150, Percent_Identity=42.6666666666667, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI78709078, Length=150, Percent_Identity=42.6666666666667, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26808; Mature: 26808

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTSKEGQSVPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEECCCCCCCEEEEEEHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHH
LHSVFKENGVDDILCVSVNDTFVMNAWKADQEAENITFIPDGNGEFTDGMGMLVEKNDLG
HHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCC
FGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTMLNYLAPEHKEQESITVFTKPG
CCCCCEEEEEEHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECCC
CPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAITGRTTVPQVFIGGKHIGGSEELEAF
CCHHHHHHHHHHHCCCCHHEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCHHHHHHH
LA
CC
>Mature Secondary Structure
MFTSKEGQSVPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEECCCCCCCEEEEEEHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHH
LHSVFKENGVDDILCVSVNDTFVMNAWKADQEAENITFIPDGNGEFTDGMGMLVEKNDLG
HHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCC
FGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTMLNYLAPEHKEQESITVFTKPG
CCCCCEEEEEEHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECCC
CPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAITGRTTVPQVFIGGKHIGGSEELEAF
CCHHHHHHHHHHHCCCCHHEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCHHHHHHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]