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The map label for this gene is hlyB [H]

Identifier: 59712843

GI number: 59712843

Start: 2511077

End: 2512678

Strand: Reverse

Name: hlyB [H]

Synonym: VF_2236

Alternate gene names: 59712843

Gene position: 2512678-2511077 (Counterclockwise)

Preceding gene: 59712845

Following gene: 59712842

Centisome position: 86.72

GC content: 39.89

Gene sequence:

>1602_bases
ATGTCAGTAATAACGTTTAAGCCATGGGAAAGGCTAGTCACCGATATTAAACTGGTACCAAAGTTGGTCATGTTAATGGT
ATTTAGTACTATATTGTTGGTAACGAAACAGTTATGGGATGCAAACACATTTTATCAATCCGTTATTACTATTCAGAAAG
AGCGAGCACAAGAATCAGCAATGGCGAATGCTGAACTTGTTAATCGTCTACTTAATTATAACGCTGAAGGAAAAGAGTTA
GCTGCAGAAGCCATCACAATTCAAGCTAAGGGCTGGAAAGATGGTAACTACATTTATGTTATTGATCGTGATAGTGGTAA
AGTCTTTGGGCACCAATCAGCGACAGCACTGTCATCTTTGACTCAATCGCTAGACGACGGTGGGTCATTGCAAAAAGTAT
TTGAACAACTCGCTTCTAATAAAACCTATTCATTACTTGATCACACTCGATATGAGTCAGCCGTTAAAGTTCCAGATCAT
AACTGGGTTGTTGTGGCCTCTCAATCAGCCAGTGTTGCAGAGCAATATTATCAAGATTATCTCACACAAGTGATCTGGCA
AACCTTGGCAATGATTGTGTCATTCATGGTTATTTTACTTGGTGCTTCAAGCATTATGTTGAGACAAATGAAATATTTGA
ATACGTCAATGAAGCAGATCGCGGAGCAAAATTTATCAGAGCCAGTAGAGATGAACTGTAAAGATGAATTTGGTGATTTA
GCAAGAGAGTTGAATAAAACACGATTACAACTAAAGAGTGTTGTTGAGACTCAGTTATCAGCTTCTCAAGAGCTAGCGGG
TTTAACTGAAATCATGACTATTAGTATGGAAGGTACAAAGGAAGCGGCTCAAGAGGAGTTTGCAGAAATTGACCAGCTAG
CAACAGCGATGAGTGAAATGAACTCAACGGTTCAAAATGTGGCTGAGAATGCACGTAATGCTTCAATTGGAACTGAACAA
GCTCAATCTCAAGCGAATATTGGTCAAGAGTTTGTAGAAGGTACGATTGTTAAGATCCAAGCATTGTCTGGCGATATTGC
AGCGTCAGCTGAAGTGGTCAATCAAGTTGAAGAACGAGTGGTTTCTATTAGCTCTGTTGTTGAAACCATTCGTGGTATTT
CAGAACAAACTAACTTACTTGCTCTTAATGCGGCAATTGAAGCTGCTCGTGCTGGTGATGCTGGTCGTGGTTTTGCAGTT
GTTGCCGATGAAGTGAGAAATCTTGCTCAAAGCACTCAAGGAGCAACAGTCGAAATTCAAGATATGATCACGCAACTTCA
AAATAGTGCTAATCAAGCAGTAGAGTTGATGGAAAAAAGCGTAGTTGAAGCGGCGGAAGGCGTTGAACTTGTTACGAATG
CAGGATCTGAACTCGATCGCATTGTTGAGCAAGTAAATAAAATCAACGAAATGAATTTCCAGATCGCAAGTGCGGCTGAT
CAACAAAGCAGCGTAGCAGAAGAAATGGATCAAAACCTAACCAATGTGAGAGAGTTGGTTGATGCTTCTGTTGTGGTGAT
GACTGAATTAACGGAAACCTCAGAAGAAATGCAGAAAAATGCAGAAGAGTTAGAGTCAAAAATGAAGGTTTTTAAAATCT
AG

Upstream 100 bases:

>100_bases
TTATGCATTTCCGTTAAAAACAAAAGTGATGTGTGTATCTGCATGAAGCATTTTTATCATGCACTAAAAAATTTAATTCT
GAAAGGTTGCGGGAGAAACT

Downstream 100 bases:

>100_bases
CTTATCCGACTTTAAAATTAATAACGCCTACACTCCAGTTGTAGGCGTTTTTGTTTGCGGCTAAAACTAAAATTTGGCAC
AGTGTTATTTGCTCTATGTA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MSVITFKPWERLVTDIKLVPKLVMLMVFSTILLVTKQLWDANTFYQSVITIQKERAQESAMANAELVNRLLNYNAEGKEL
AAEAITIQAKGWKDGNYIYVIDRDSGKVFGHQSATALSSLTQSLDDGGSLQKVFEQLASNKTYSLLDHTRYESAVKVPDH
NWVVVASQSASVAEQYYQDYLTQVIWQTLAMIVSFMVILLGASSIMLRQMKYLNTSMKQIAEQNLSEPVEMNCKDEFGDL
ARELNKTRLQLKSVVETQLSASQELAGLTEIMTISMEGTKEAAQEEFAEIDQLATAMSEMNSTVQNVAENARNASIGTEQ
AQSQANIGQEFVEGTIVKIQALSGDIAASAEVVNQVEERVVSISSVVETIRGISEQTNLLALNAAIEAARAGDAGRGFAV
VADEVRNLAQSTQGATVEIQDMITQLQNSANQAVELMEKSVVEAAEGVELVTNAGSELDRIVEQVNKINEMNFQIASAAD
QQSSVAEEMDQNLTNVRELVDASVVVMTELTETSEEMQKNAEELESKMKVFKI

Sequences:

>Translated_533_residues
MSVITFKPWERLVTDIKLVPKLVMLMVFSTILLVTKQLWDANTFYQSVITIQKERAQESAMANAELVNRLLNYNAEGKEL
AAEAITIQAKGWKDGNYIYVIDRDSGKVFGHQSATALSSLTQSLDDGGSLQKVFEQLASNKTYSLLDHTRYESAVKVPDH
NWVVVASQSASVAEQYYQDYLTQVIWQTLAMIVSFMVILLGASSIMLRQMKYLNTSMKQIAEQNLSEPVEMNCKDEFGDL
ARELNKTRLQLKSVVETQLSASQELAGLTEIMTISMEGTKEAAQEEFAEIDQLATAMSEMNSTVQNVAENARNASIGTEQ
AQSQANIGQEFVEGTIVKIQALSGDIAASAEVVNQVEERVVSISSVVETIRGISEQTNLLALNAAIEAARAGDAGRGFAV
VADEVRNLAQSTQGATVEIQDMITQLQNSANQAVELMEKSVVEAAEGVELVTNAGSELDRIVEQVNKINEMNFQIASAAD
QQSSVAEEMDQNLTNVRELVDASVVVMTELTETSEEMQKNAEELESKMKVFKI
>Mature_532_residues
SVITFKPWERLVTDIKLVPKLVMLMVFSTILLVTKQLWDANTFYQSVITIQKERAQESAMANAELVNRLLNYNAEGKELA
AEAITIQAKGWKDGNYIYVIDRDSGKVFGHQSATALSSLTQSLDDGGSLQKVFEQLASNKTYSLLDHTRYESAVKVPDHN
WVVVASQSASVAEQYYQDYLTQVIWQTLAMIVSFMVILLGASSIMLRQMKYLNTSMKQIAEQNLSEPVEMNCKDEFGDLA
RELNKTRLQLKSVVETQLSASQELAGLTEIMTISMEGTKEAAQEEFAEIDQLATAMSEMNSTVQNVAENARNASIGTEQA
QSQANIGQEFVEGTIVKIQALSGDIAASAEVVNQVEERVVSISSVVETIRGISEQTNLLALNAAIEAARAGDAGRGFAVV
ADEVRNLAQSTQGATVEIQDMITQLQNSANQAVELMEKSVVEAAEGVELVTNAGSELDRIVEQVNKINEMNFQIASAADQ
QSSVAEEMDQNLTNVRELVDASVVVMTELTETSEEMQKNAEELESKMKVFKI

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=307, Percent_Identity=33.8762214983713, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788194, Length=355, Percent_Identity=29.8591549295775, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788195, Length=284, Percent_Identity=31.6901408450704, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1787690, Length=342, Percent_Identity=28.3625730994152, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1789453, Length=322, Percent_Identity=26.7080745341615, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 58588; Mature: 58457

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVITFKPWERLVTDIKLVPKLVMLMVFSTILLVTKQLWDANTFYQSVITIQKERAQESA
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
MANAELVNRLLNYNAEGKELAAEAITIQAKGWKDGNYIYVIDRDSGKVFGHQSATALSSL
HHHHHHHHHHHCCCCCCHHHHHHHEEEEECCCCCCCEEEEEECCCCCEECCHHHHHHHHH
TQSLDDGGSLQKVFEQLASNKTYSLLDHTRYESAVKVPDHNWVVVASQSASVAEQYYQDY
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCEEECCCCCEEEEECCCHHHHHHHHHHH
LTQVIWQTLAMIVSFMVILLGASSIMLRQMKYLNTSMKQIAEQNLSEPVEMNCKDEFGDL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ARELNKTRLQLKSVVETQLSASQELAGLTEIMTISMEGTKEAAQEEFAEIDQLATAMSEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHH
NSTVQNVAENARNASIGTEQAQSQANIGQEFVEGTIVKIQALSGDIAASAEVVNQVEERV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHH
VSISSVVETIRGISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRNLAQSTQGATVEIQ
HHHHHHHHHHHCCHHHCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEHH
DMITQLQNSANQAVELMEKSVVEAAEGVELVTNAGSELDRIVEQVNKINEMNFQIASAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHCC
QQSSVAEEMDQNLTNVRELVDASVVVMTELTETSEEMQKNAEELESKMKVFKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVITFKPWERLVTDIKLVPKLVMLMVFSTILLVTKQLWDANTFYQSVITIQKERAQESA
CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
MANAELVNRLLNYNAEGKELAAEAITIQAKGWKDGNYIYVIDRDSGKVFGHQSATALSSL
HHHHHHHHHHHCCCCCCHHHHHHHEEEEECCCCCCCEEEEEECCCCCEECCHHHHHHHHH
TQSLDDGGSLQKVFEQLASNKTYSLLDHTRYESAVKVPDHNWVVVASQSASVAEQYYQDY
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCEEECCCCCEEEEECCCHHHHHHHHHHH
LTQVIWQTLAMIVSFMVILLGASSIMLRQMKYLNTSMKQIAEQNLSEPVEMNCKDEFGDL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ARELNKTRLQLKSVVETQLSASQELAGLTEIMTISMEGTKEAAQEEFAEIDQLATAMSEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHH
NSTVQNVAENARNASIGTEQAQSQANIGQEFVEGTIVKIQALSGDIAASAEVVNQVEERV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHH
VSISSVVETIRGISEQTNLLALNAAIEAARAGDAGRGFAVVADEVRNLAQSTQGATVEIQ
HHHHHHHHHHHCCHHHCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEHH
DMITQLQNSANQAVELMEKSVVEAAEGVELVTNAGSELDRIVEQVNKINEMNFQIASAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHCC
QQSSVAEEMDQNLTNVRELVDASVVVMTELTETSEEMQKNAEELESKMKVFKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]