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The map label for this gene is murC [H]

Identifier: 59712807

GI number: 59712807

Start: 2471166

End: 2472629

Strand: Reverse

Name: murC [H]

Synonym: VF_2200

Alternate gene names: 59712807

Gene position: 2472629-2471166 (Counterclockwise)

Preceding gene: 59712808

Following gene: 172087760

Centisome position: 85.34

GC content: 40.64

Gene sequence:

>1464_bases
ATGACAAAAGAACAGAAACTGCAATTAGCTGAAATAAGAACCATGATCCCTGAAATGCGTCGTGTGGAGTGCATTCACTT
CGTTGGTATTGGTGGCGCAGGAATGAGTGGTATTGCGGAAGTACTTTTAAATGAAGGTTATCACATTAGTGGTTCCGATA
TGGCTGAGAACACAGTCACTGTTCGTTTAGCACAAAAAGGTGCTGAGATCTTCTTTGGACACCAAGCAAGTAATGTTGCA
AAAGCGAGTGTTGTAGTTGTATCTACTGCCATTGATCCAAGTAATCCTGAAATTGTAGCGGCGAAAGAAAATCGTATTCC
AGTGATTCGTCGTGCAGAAATGTTAGCTGAATTGATGCGTTACCGTCATGGTATTGCTGTCGCTGGTACTCACGGTAAAA
CCACAACAACAGCGTTAACTACGCAGATTTATTCTGAAGCAGGATTAGATCCAACATTTGTAAATGGTGGGTTAGTTAAG
AATGCAGGTACAAATGCACGTTTAGGCTCGAGCCGATTCTTAATTGCTGAAGCGGATGAAAGTGATGCGTCATTCTTACA
CCTACAACCTATGGTTAGTATTGTTACGAATATCGAAGCAGACCATATGGACACGTATGGTGGTGATTTTGAAACGTTAA
AACAAACGTTTATCGATTTTTTACATAACCTTCCATTTTATGGTCAAGCGGTAATGTGTGTTGATGATCCGGTTGTTCGA
GAATTATTACCGCAAGTGAGCCGTCAGGTGATTACTTATGGTTTCTCTGATGATGCAGATGTACGTTTAATTAATTATCG
TCAAGTTGGTCAGCAAAGTTTCTTTACGGTTCAAAGAAAAGATCGTACTGATTTGGATATTGTTTTGAATATCCCTGGCA
AACATAATGCCTTGAATGCTACCGCTGCAATTGCAGTAGCAACAGAAGAAGATGTTGAAGATGAAGCAATTCTTACTGCG
CTATTAAACTTTGAAGGCGCGGGTCGTCGTTTCGATCAACTTGGTGAATTTGAAACTGGCAATGGCTCAGCAATGTTAGT
AGATGATTACGGTCATCACCCAACAGAAGTTGACGTAACCATTAAAGCAGCTCGTGCTGGCTGGGCAGAGAAGCGTTTGG
TTATGATTTTCCAACCACACCGTTATAGCCGAACTCGTGATTTATATGACGACTTTGCTAATGTATTAGATAATGTTGAT
GTATTAATCATGCTTGATGTTTATTCAGCGGGTGAAACGCCAATTGCAGGTGCTGATGGGCGAGCGTTATGTCGTACTAT
CCGTGGTCGTGGAAAAATAGATCCGGTATTTGTACCGACAATAGAGGCATTACCACCTGTTTTAGCGAATATAATTCAAG
AAGGTGACTTAATCCTGACGCAAGGCGCTGGAGATGTTGGTAAATTAGCTAAGCAATTGGCTTCAATGGAATTAAATATT
GAAACAATGAAAAAGTTAGGATAA

Upstream 100 bases:

>100_bases
CGAAATGGCATGTAATGCTCGAGACGCAGCAATTATCGATGCTGATGTGCGTGTTGCTAATGCAATAAAAAGCCTCGCTA
AATAAGAATTGAGATTAAGA

Downstream 100 bases:

>100_bases
TTATTGTTTAATTAGTTAGAACTTCTAATAAAAAAACGAATAATGGGATAGAATCCTCATTGTATTAATAATATGCTATC
AGAGTTTGGATAGAGGGTTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTKEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDMAENTVTVRLAQKGAEIFFGHQASNVA
KASVVVVSTAIDPSNPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVK
NAGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
ELLPQVSRQVITYGFSDDADVRLINYRQVGQQSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDEAILTA
LLNFEGAGRRFDQLGEFETGNGSAMLVDDYGHHPTEVDVTIKAARAGWAEKRLVMIFQPHRYSRTRDLYDDFANVLDNVD
VLIMLDVYSAGETPIAGADGRALCRTIRGRGKIDPVFVPTIEALPPVLANIIQEGDLILTQGAGDVGKLAKQLASMELNI
ETMKKLG

Sequences:

>Translated_487_residues
MTKEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDMAENTVTVRLAQKGAEIFFGHQASNVA
KASVVVVSTAIDPSNPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVK
NAGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
ELLPQVSRQVITYGFSDDADVRLINYRQVGQQSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDEAILTA
LLNFEGAGRRFDQLGEFETGNGSAMLVDDYGHHPTEVDVTIKAARAGWAEKRLVMIFQPHRYSRTRDLYDDFANVLDNVD
VLIMLDVYSAGETPIAGADGRALCRTIRGRGKIDPVFVPTIEALPPVLANIIQEGDLILTQGAGDVGKLAKQLASMELNI
ETMKKLG
>Mature_486_residues
TKEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDMAENTVTVRLAQKGAEIFFGHQASNVAK
ASVVVVSTAIDPSNPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKN
AGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVRE
LLPQVSRQVITYGFSDDADVRLINYRQVGQQSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDEAILTAL
LNFEGAGRRFDQLGEFETGNGSAMLVDDYGHHPTEVDVTIKAARAGWAEKRLVMIFQPHRYSRTRDLYDDFANVLDNVDV
LIMLDVYSAGETPIAGADGRALCRTIRGRGKIDPVFVPTIEALPPVLANIIQEGDLILTQGAGDVGKLAKQLASMELNIE
TMKKLG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=480, Percent_Identity=70.4166666666667, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=474, Percent_Identity=27.2151898734177, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53147; Mature: 53016

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDMAENTVT
CCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCEEE
VRLAQKGAEIFFGHQASNVAKASVVVVSTAIDPSNPEIVAAKENRIPVIRRAEMLAELMR
EEEECCCCEEEECCCCCCCCEEEEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKNAGTNARLGSSRFLIAEADE
HHCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELLPQVSRQVITYGFSDDADVRLINYRQVGQQSFFTVQRKDRTDLDIVLNIPGKHNALNA
HHHHHHHHHHEEECCCCCCCEEEEEHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
TAAIAVATEEDVEDEAILTALLNFEGAGRRFDQLGEFETGNGSAMLVDDYGHHPTEVDVT
EEEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHCCCEECCCCCEEEEECCCCCCCEEEEE
IKAARAGWAEKRLVMIFQPHRYSRTRDLYDDFANVLDNVDVLIMLDVYSAGETPIAGADG
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCH
RALCRTIRGRGKIDPVFVPTIEALPPVLANIIQEGDLILTQGAGDVGKLAKQLASMELNI
HHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCH
ETMKKLG
HHHHHCC
>Mature Secondary Structure 
TKEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDMAENTVT
CHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCCCEEE
VRLAQKGAEIFFGHQASNVAKASVVVVSTAIDPSNPEIVAAKENRIPVIRRAEMLAELMR
EEEECCCCEEEECCCCCCCCEEEEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKNAGTNARLGSSRFLIAEADE
HHCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVSIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAVMCVDDPVVR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELLPQVSRQVITYGFSDDADVRLINYRQVGQQSFFTVQRKDRTDLDIVLNIPGKHNALNA
HHHHHHHHHHEEECCCCCCCEEEEEHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
TAAIAVATEEDVEDEAILTALLNFEGAGRRFDQLGEFETGNGSAMLVDDYGHHPTEVDVT
EEEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHCCCEECCCCCEEEEECCCCCCCEEEEE
IKAARAGWAEKRLVMIFQPHRYSRTRDLYDDFANVLDNVDVLIMLDVYSAGETPIAGADG
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCH
RALCRTIRGRGKIDPVFVPTIEALPPVLANIIQEGDLILTQGAGDVGKLAKQLASMELNI
HHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCH
ETMKKLG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA