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The map label for this gene is exo I [H]

Identifier: 59712753

GI number: 59712753

Start: 2399691

End: 2401598

Strand: Direct

Name: exo I [H]

Synonym: VF_2146

Alternate gene names: 59712753

Gene position: 2399691-2401598 (Clockwise)

Preceding gene: 59712752

Following gene: 59712754

Centisome position: 82.82

GC content: 38.26

Gene sequence:

>1908_bases
ATGATGGATTATCGTGTAGACCTTGTTGTCTTATCAGACAAAGAAAAGTTAAACCGTTTTGGCTTAACCTTACATAATTT
AAGCGATGTGGATCTTCATCATTGGCAATTACAATTTACTATTGATCGTTTTATTGCACCTGAAAGTAATTCCCAAGGAA
CATTAGAACAAGTCGGTAGTTTTTGTAAATTAACTCCAGATGCCAACCAAGTACTAAAAGCAAATAATCACTATTATGTT
GAATTTAGTATTGGTACCGCACCTTTTCGCTTTATCACCGATGGTTTAGATGATGCCGCTATTTTTGTTGATGATGGCAA
AAATACTCATTTTTTAGATGTATCGATCTCACCGATTGTTTTGGCTTCACCATACTCAGAGAGAACGTCTATCCCTAGAG
TTGCTCCTTCTGAACTGTCTCTTATTCCAAAACCAGAATCAGTACAACGTTTTGATGGCCAATTTAATCTAAAAGATAAA
ATCTCTCTAGAAACACAAACCCATTTAGCACAAGGTGCCGCCCAGTGGTTAAGTGATGAATTAGAAAACATTACTTCTTT
AAAGTATCCGATTAAATCACAAGGTCAGATCCAATTCATTGCTAATCCAACATTAGATAAAGGTGCATATCAACTTTCAG
TATCTGAAGATATCATCACTCTTACTGCAGGCTCTAATGAGGGATTCGTTCACGCATCTGCGACGCTTTTGCAATTAATA
AATGAAAGAACACACTTAATCCCGTGTGCAAAAATCAAAGACCAACCACGCTTTCACTATCGTGGAATGATGCTAGATTG
TGCAAGACACTTCCATCCACTAGAGCGTGTAAAACGTTTAATTAATCAATTAGCTCATTATAAATTTAACACTTTCCATT
GGCATTTAACGGATGACGAAGGATGGCGAGTAGAAATAAAAGCCTTTCCTGAATTAACGCAAATTGGTGCATGGCGTGGG
CCAGAAGAAGTGATTGAGCCACAATACACTCATATAGCAGAAAAGCATGGTGGTTATTATTCTCAAGAAGAGATTAAAGA
CGTCATTGCTTATGCAGAACAGCGTGGAATAACAGTAATACCTGAAATCGATATTCCAGGCCATTGCCGTGCAGCTATTA
AATCACTACCTCATTTGTTAATTGATTCTGACGATAATTCGGTTTATCGCAGTATTCAACACTACACAGATAATGTGCTA
TCACCGGCAATCGAAGGTACCTATCAATTTATTGATACTGTGCTCGAAGAAATTGCAGATCTTTTCCCTGCACCATACGT
TCATATTGGTGCAGATGAAGTTCCAAAAGGGGTTTGGACTGATAGTGAAAAATGTCAAAAATTAATGGAAGAGCAAGGTT
ATAGCGACCCTGTTGAATTGCAAGGTCACCTACTTCGTCATGCTGAAAACAAATTAAAACAACTAGGCAAACAGATGCTT
GGTTGGGAAGAAGCTCAGCATGGTAATAAAGTCAGCAAAGATACCGTTATTTACTCTTGGTTAAGTGAAGAAGCAGCATT
AAATTGTGCCAAACAAGGTTTTGATGTCGTACTCCAACCCGGTCAAACCACCTATTTAGATATGGCACAAGATTATGCTC
CTGAAGAGCCTGGAGTAGATTGGGCAAATGTTCTTCCTCTTGAAGAGGCTTATAACTACGAACCTCTTGCTGAATTAGCT
GATAACGACCCTATTCGTAAACGCATTCTCGGAATTCAATGTGCACTTTGGTGTGAAATCATCAATAACCAAGAGCGCAT
GGATTACATGATTTTCCCACGTCTTTTAGCAATATCTGAAGGAATGTGGACACAAAAACAACACAGAAACTGGACAGACT
TTTTAGCAAGGTTAAATGGACGATTACCAACCCTAACACGTCAGGGTATTAATTTCCGTCAACCATAA

Upstream 100 bases:

>100_bases
GTCAATATTTAGTACAGCCGCAATTTGATGCCATTGAAGGTGGCATTATGATGGCAAGAAACAAAGAACATAACCTGTTC
TAGTCTTTTATAAGGAAAAG

Downstream 100 bases:

>100_bases
GTCACCCATTTATTAGTATTTTAGTTAAGGATAAAAAAATGAAATACGGTTTTTTCGATAACGACAATCGTGAATATGTC
ATCACACGCCCTGACGTACC

Product: beta-hexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MMDYRVDLVVLSDKEKLNRFGLTLHNLSDVDLHHWQLQFTIDRFIAPESNSQGTLEQVGSFCKLTPDANQVLKANNHYYV
EFSIGTAPFRFITDGLDDAAIFVDDGKNTHFLDVSISPIVLASPYSERTSIPRVAPSELSLIPKPESVQRFDGQFNLKDK
ISLETQTHLAQGAAQWLSDELENITSLKYPIKSQGQIQFIANPTLDKGAYQLSVSEDIITLTAGSNEGFVHASATLLQLI
NERTHLIPCAKIKDQPRFHYRGMMLDCARHFHPLERVKRLINQLAHYKFNTFHWHLTDDEGWRVEIKAFPELTQIGAWRG
PEEVIEPQYTHIAEKHGGYYSQEEIKDVIAYAEQRGITVIPEIDIPGHCRAAIKSLPHLLIDSDDNSVYRSIQHYTDNVL
SPAIEGTYQFIDTVLEEIADLFPAPYVHIGADEVPKGVWTDSEKCQKLMEEQGYSDPVELQGHLLRHAENKLKQLGKQML
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVDWANVLPLEEAYNYEPLAELA
DNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAISEGMWTQKQHRNWTDFLARLNGRLPTLTRQGINFRQP

Sequences:

>Translated_635_residues
MMDYRVDLVVLSDKEKLNRFGLTLHNLSDVDLHHWQLQFTIDRFIAPESNSQGTLEQVGSFCKLTPDANQVLKANNHYYV
EFSIGTAPFRFITDGLDDAAIFVDDGKNTHFLDVSISPIVLASPYSERTSIPRVAPSELSLIPKPESVQRFDGQFNLKDK
ISLETQTHLAQGAAQWLSDELENITSLKYPIKSQGQIQFIANPTLDKGAYQLSVSEDIITLTAGSNEGFVHASATLLQLI
NERTHLIPCAKIKDQPRFHYRGMMLDCARHFHPLERVKRLINQLAHYKFNTFHWHLTDDEGWRVEIKAFPELTQIGAWRG
PEEVIEPQYTHIAEKHGGYYSQEEIKDVIAYAEQRGITVIPEIDIPGHCRAAIKSLPHLLIDSDDNSVYRSIQHYTDNVL
SPAIEGTYQFIDTVLEEIADLFPAPYVHIGADEVPKGVWTDSEKCQKLMEEQGYSDPVELQGHLLRHAENKLKQLGKQML
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVDWANVLPLEEAYNYEPLAELA
DNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAISEGMWTQKQHRNWTDFLARLNGRLPTLTRQGINFRQP
>Mature_635_residues
MMDYRVDLVVLSDKEKLNRFGLTLHNLSDVDLHHWQLQFTIDRFIAPESNSQGTLEQVGSFCKLTPDANQVLKANNHYYV
EFSIGTAPFRFITDGLDDAAIFVDDGKNTHFLDVSISPIVLASPYSERTSIPRVAPSELSLIPKPESVQRFDGQFNLKDK
ISLETQTHLAQGAAQWLSDELENITSLKYPIKSQGQIQFIANPTLDKGAYQLSVSEDIITLTAGSNEGFVHASATLLQLI
NERTHLIPCAKIKDQPRFHYRGMMLDCARHFHPLERVKRLINQLAHYKFNTFHWHLTDDEGWRVEIKAFPELTQIGAWRG
PEEVIEPQYTHIAEKHGGYYSQEEIKDVIAYAEQRGITVIPEIDIPGHCRAAIKSLPHLLIDSDDNSVYRSIQHYTDNVL
SPAIEGTYQFIDTVLEEIADLFPAPYVHIGADEVPKGVWTDSEKCQKLMEEQGYSDPVELQGHLLRHAENKLKQLGKQML
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVDWANVLPLEEAYNYEPLAELA
DNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAISEGMWTQKQHRNWTDFLARLNGRLPTLTRQGINFRQP

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI189181666, Length=435, Percent_Identity=29.1954022988506, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI4504373, Length=457, Percent_Identity=26.6958424507659, Blast_Score=166, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17569815, Length=471, Percent_Identity=27.3885350318471, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24653074, Length=454, Percent_Identity=27.0925110132159, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551090, Length=454, Percent_Identity=27.0925110132159, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281365639, Length=439, Percent_Identity=23.9179954441913, Blast_Score=123, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24657474, Length=439, Percent_Identity=23.9179954441913, Blast_Score=123, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24657468, Length=439, Percent_Identity=23.9179954441913, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17647501, Length=439, Percent_Identity=23.9179954441913, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17933586, Length=445, Percent_Identity=22.4719101123595, Blast_Score=110, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 72408; Mature: 72408

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDYRVDLVVLSDKEKLNRFGLTLHNLSDVDLHHWQLQFTIDRFIAPESNSQGTLEQVGS
CCCEEEEEEEECCHHHHHHHCCEEECCCCCCEEEEEEEEEEEHHCCCCCCCCCCHHHHCC
FCKLTPDANQVLKANNHYYVEFSIGTAPFRFITDGLDDAAIFVDDGKNTHFLDVSISPIV
CEECCCCHHHHEECCCEEEEEEEECCCCHHHHHCCCCCEEEEEECCCCEEEEEEECCCEE
LASPYSERTSIPRVAPSELSLIPKPESVQRFDGQFNLKDKISLETQTHLAQGAAQWLSDE
EECCCHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHH
LENITSLKYPIKSQGQIQFIANPTLDKGAYQLSVSEDIITLTAGSNEGFVHASATLLQLI
HHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCCCEEEHHHHHHHHH
NERTHLIPCAKIKDQPRFHYRGMMLDCARHFHPLERVKRLINQLAHYKFNTFHWHLTDDE
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEECEEEEEEECCC
GWRVEIKAFPELTQIGAWRGPEEVIEPQYTHIAEKHGGYYSQEEIKDVIAYAEQRGITVI
CCEEEEEECCCHHHHCCCCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEE
PEIDIPGHCRAAIKSLPHLLIDSDDNSVYRSIQHYTDNVLSPAIEGTYQFIDTVLEEIAD
ECCCCCCHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFPAPYVHIGADEVPKGVWTDSEKCQKLMEEQGYSDPVELQGHLLRHAENKLKQLGKQML
HCCCCEEEECHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVD
CCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHCCCCCCCCC
WANVLPLEEAYNYEPLAELADNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAISE
HHHCCCHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
GMWTQKQHRNWTDFLARLNGRLPTLTRQGINFRQP
CCCCHHHCCCHHHHHHHHCCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MMDYRVDLVVLSDKEKLNRFGLTLHNLSDVDLHHWQLQFTIDRFIAPESNSQGTLEQVGS
CCCEEEEEEEECCHHHHHHHCCEEECCCCCCEEEEEEEEEEEHHCCCCCCCCCCHHHHCC
FCKLTPDANQVLKANNHYYVEFSIGTAPFRFITDGLDDAAIFVDDGKNTHFLDVSISPIV
CEECCCCHHHHEECCCEEEEEEEECCCCHHHHHCCCCCEEEEEECCCCEEEEEEECCCEE
LASPYSERTSIPRVAPSELSLIPKPESVQRFDGQFNLKDKISLETQTHLAQGAAQWLSDE
EECCCHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHH
LENITSLKYPIKSQGQIQFIANPTLDKGAYQLSVSEDIITLTAGSNEGFVHASATLLQLI
HHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCCCEEEHHHHHHHHH
NERTHLIPCAKIKDQPRFHYRGMMLDCARHFHPLERVKRLINQLAHYKFNTFHWHLTDDE
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEECEEEEEEECCC
GWRVEIKAFPELTQIGAWRGPEEVIEPQYTHIAEKHGGYYSQEEIKDVIAYAEQRGITVI
CCEEEEEECCCHHHHCCCCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEE
PEIDIPGHCRAAIKSLPHLLIDSDDNSVYRSIQHYTDNVLSPAIEGTYQFIDTVLEEIAD
ECCCCCCHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFPAPYVHIGADEVPKGVWTDSEKCQKLMEEQGYSDPVELQGHLLRHAENKLKQLGKQML
HCCCCEEEECHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVD
CCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHCCCCCCCCC
WANVLPLEEAYNYEPLAELADNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAISE
HHHCCCHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
GMWTQKQHRNWTDFLARLNGRLPTLTRQGINFRQP
CCCCHHHCCCHHHHHHHHCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]