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The map label for this gene is arcA [H]

Identifier: 59712727

GI number: 59712727

Start: 2356436

End: 2357155

Strand: Direct

Name: arcA [H]

Synonym: VF_2120

Alternate gene names: 59712727

Gene position: 2356436-2357155 (Clockwise)

Preceding gene: 59712722

Following gene: 59712731

Centisome position: 81.33

GC content: 42.36

Gene sequence:

>720_bases
ATGCAAACCCCACAGATCCTAATCGTTGAAGATGAACACGTAACTCGTAATACGTTAAAAAGCATTTTTGAAGCTGAAGG
CTACAATGTTTTTGAAGCTAGCGATGGCGAAGAAATGCATAAAGTGCTTTCTGAACAGCAGCTTAATCTTGTGATTATGG
ATATTAACCTGCCAGGTAAAAATGGCCTTCTTCTTGCTCGCGAACTTCGTGAACGAGGCGATATGGCATTAATGTTCCTA
ACAGGCCGTGATAATGAAGTTGATAAGATTTTAGGTTTAGAAATTGGCGCTGATGATTACATCACAAAACCATTCAACCC
ACGTGAACTGACTATTCGTGCACGTAACTTATTAACTCGTTCAATGAACCAAAACACAGTTGTTGAAGATAAGAAAATGG
TTGAGCGCTATGTGTTCAACGGTTGGACTGTAGAAATCAACAGCCGTTCTCTTGTTAGCCCAAGCGGTGAGAGCTACAAG
CTTCCACGTTCTGAATTCCGTGCTCTGCTTCACTTCTGTGAAAACCCAGGCAAAATCCAGACTCGTGCAGATCTACTGAA
AAAAATGACTGGTCGTGAGCTTAAACCACACGATCGTACAGTAGACGTAACTATCCGTCGCATCCGTAAGCACTTTGAAT
CTGTAACTGATACACCAGAGATCATCGCTACAATTCACGGTGAAGGCTACCGCTTCTGTGGTGACCTAGAAGAGCTATAA

Upstream 100 bases:

>100_bases
ACTATTGAAGAATCTATTTTCCTATTTGTAAATTTTTTATTATAGAATTAAAATTTGTTAATTCTACTTTTGACTTTAAC
CAGTTAGTTAGGTACCGCCC

Downstream 100 bases:

>100_bases
GAATCTCTTCTATCTGACTTTAAATAAAATGCCCAGCTAGTGATAGCTGGGCATTTTTTATCTATATAACATAGTATTAA
TATACTGTATCAACACTCAC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHKVLSEQQLNLVIMDINLPGKNGLLLARELRERGDMALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRSMNQNTVVEDKKMVERYVFNGWTVEINSRSLVSPSGESYK
LPRSEFRALLHFCENPGKIQTRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL

Sequences:

>Translated_239_residues
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHKVLSEQQLNLVIMDINLPGKNGLLLARELRERGDMALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRSMNQNTVVEDKKMVERYVFNGWTVEINSRSLVSPSGESYK
LPRSEFRALLHFCENPGKIQTRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL
>Mature_239_residues
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHKVLSEQQLNLVIMDINLPGKNGLLLARELRERGDMALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRSMNQNTVVEDKKMVERYVFNGWTVEINSRSLVSPSGESYK
LPRSEFRALLHFCENPGKIQTRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=84.0336134453782, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=40.343347639485, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.4763948497854, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=241, Percent_Identity=31.1203319502075, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.4561403508772, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=31.7596566523605, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=29.6943231441048, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=30.3964757709251, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.9661016949153, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=26.8722466960352, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=30.3418803418803, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27490; Mature: 27490

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHKVLSEQQLNLVIMDINLPGK
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCC
NGLLLARELRERGDMALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEEHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
SMNQNTVVEDKKMVERYVFNGWTVEINSRSLVSPSGESYKLPRSEFRALLHFCENPGKIQ
CCCCCCCHHHHHHHHHHHHCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCH
TRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHKVLSEQQLNLVIMDINLPGK
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCC
NGLLLARELRERGDMALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEEHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
SMNQNTVVEDKKMVERYVFNGWTVEINSRSLVSPSGESYKLPRSEFRALLHFCENPGKIQ
CCCCCCCHHHHHHHHHHHHCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCH
TRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]