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The map label for this gene is metA [H]

Identifier: 59712670

GI number: 59712670

Start: 2298357

End: 2299301

Strand: Direct

Name: metA [H]

Synonym: VF_2063

Alternate gene names: 59712670

Gene position: 2298357-2299301 (Clockwise)

Preceding gene: 59712666

Following gene: 59712671

Centisome position: 79.32

GC content: 38.62

Gene sequence:

>945_bases
TTGTGCCGATCAAAATACCTGACCAACTCCCTGACAACTGAAGTATTACGTGAAGAGAATATCTTTTTCATGCAGGAATC
TCGTGCCACCACACAAGCGATTCGACCTCTTAAAGTCATTATTTTAAATTTAATGCCAAAAAAGATTGAGACAGAAACTC
AATTTTTACGCCTACTATCTAATAGCCCATTACAAGTGGATGTAGAGCTATTACGTATTGATAATCGCACTAGTAAAAAT
ACACCAACCGAGCATTTAGATACTTTTTATCGTCAGTTTGAAGGCATTAAAGATCGTAACTTTGATGGCCTAATCATAAC
AGGTGCACCACTAGGATTAGTGCAGTTTGAAGATGTTATTTATTGGGATCATCTACAAACCATCATGACATGGGCAAAAG
ATCACGTCACTTCTAGCTTATATGTATGCTGGGCAGCACAAGCTGGTTTAAAGCTACTTTATGATTTGCCAAAACGAACA
CGTAAAGAAAAGCTTTCTGGGGTTTATAAACATACTAACCTTAACCAACACCATCCTATTTTGCGTGGCTTTGATGATCA
ATTTTTAGCACCTCATTCTCGTTACGCTGATTTCTCTGCTGATTACTTAAAATCGCATACCGATTTAGATATTCTTGCTA
CCTCCAAAGAAGCCGGTGTCTATTTGGCTGCAACCAAAGATAAGCGAAATGTCTTTGTCACTGGTCATCCAGAATATGAT
TCATTCACATTACATAATGAATACGTTAGAGACTTGGGGGAAGGAATGGAGCCAACGATTCCTGTTAATTACTATCCTGA
CGACAACCCAGATATCACGCCTAAAGCAACATGGCGTAGTCATGGCCACTTGCTCTTTTCTAATTGGCTCAACTACTGTG
TTTACCAACAAACACCGTATGATCTTGAGCATTTCTCAGAGCAAAATTTCACAAGAGATGAGTAA

Upstream 100 bases:

>100_bases
CTTAAATAGCTTCAAAGGAAATAATGAACCTCGACACTCTGACCATTATGAGGTAAGTTTAGAAGTATAGACGTATGGAA
ACCCAAAACTTAAGGATAAG

Downstream 100 bases:

>100_bases
CCTTAACTCATTTTGATTAGCGGGTATTATTCTTCATAAATACCCGCTATAAGCACAAAACCACCACCACAATCTGATAA
ATAGAGCACATTTTGTCCTT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MCRSKYLTNSLTTEVLREENIFFMQESRATTQAIRPLKVIILNLMPKKIETETQFLRLLSNSPLQVDVELLRIDNRTSKN
TPTEHLDTFYRQFEGIKDRNFDGLIITGAPLGLVQFEDVIYWDHLQTIMTWAKDHVTSSLYVCWAAQAGLKLLYDLPKRT
RKEKLSGVYKHTNLNQHHPILRGFDDQFLAPHSRYADFSADYLKSHTDLDILATSKEAGVYLAATKDKRNVFVTGHPEYD
SFTLHNEYVRDLGEGMEPTIPVNYYPDDNPDITPKATWRSHGHLLFSNWLNYCVYQQTPYDLEHFSEQNFTRDE

Sequences:

>Translated_314_residues
MCRSKYLTNSLTTEVLREENIFFMQESRATTQAIRPLKVIILNLMPKKIETETQFLRLLSNSPLQVDVELLRIDNRTSKN
TPTEHLDTFYRQFEGIKDRNFDGLIITGAPLGLVQFEDVIYWDHLQTIMTWAKDHVTSSLYVCWAAQAGLKLLYDLPKRT
RKEKLSGVYKHTNLNQHHPILRGFDDQFLAPHSRYADFSADYLKSHTDLDILATSKEAGVYLAATKDKRNVFVTGHPEYD
SFTLHNEYVRDLGEGMEPTIPVNYYPDDNPDITPKATWRSHGHLLFSNWLNYCVYQQTPYDLEHFSEQNFTRDE
>Mature_314_residues
MCRSKYLTNSLTTEVLREENIFFMQESRATTQAIRPLKVIILNLMPKKIETETQFLRLLSNSPLQVDVELLRIDNRTSKN
TPTEHLDTFYRQFEGIKDRNFDGLIITGAPLGLVQFEDVIYWDHLQTIMTWAKDHVTSSLYVCWAAQAGLKLLYDLPKRT
RKEKLSGVYKHTNLNQHHPILRGFDDQFLAPHSRYADFSADYLKSHTDLDILATSKEAGVYLAATKDKRNVFVTGHPEYD
SFTLHNEYVRDLGEGMEPTIPVNYYPDDNPDITPKATWRSHGHLLFSNWLNYCVYQQTPYDLEHFSEQNFTRDE

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=291, Percent_Identity=64.9484536082474, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 36618; Mature: 36618

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCRSKYLTNSLTTEVLREENIFFMQESRATTQAIRPLKVIILNLMPKKIETETQFLRLLS
CCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
NSPLQVDVELLRIDNRTSKNTPTEHLDTFYRQFEGIKDRNFDGLIITGAPLGLVQFEDVI
CCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEHHHHH
YWDHLQTIMTWAKDHVTSSLYVCWAAQAGLKLLYDLPKRTRKEKLSGVYKHTNLNQHHPI
HHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
LRGFDDQFLAPHSRYADFSADYLKSHTDLDILATSKEAGVYLAATKDKRNVFVTGHPEYD
HCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEEECCCCEEEEECCCCCC
SFTLHNEYVRDLGEGMEPTIPVNYYPDDNPDITPKATWRSHGHLLFSNWLNYCVYQQTPY
CEEECHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCC
DLEHFSEQNFTRDE
CHHHHCCCCCCCCC
>Mature Secondary Structure
MCRSKYLTNSLTTEVLREENIFFMQESRATTQAIRPLKVIILNLMPKKIETETQFLRLLS
CCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
NSPLQVDVELLRIDNRTSKNTPTEHLDTFYRQFEGIKDRNFDGLIITGAPLGLVQFEDVI
CCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEHHHHH
YWDHLQTIMTWAKDHVTSSLYVCWAAQAGLKLLYDLPKRTRKEKLSGVYKHTNLNQHHPI
HHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
LRGFDDQFLAPHSRYADFSADYLKSHTDLDILATSKEAGVYLAATKDKRNVFVTGHPEYD
HCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEEECCCCEEEEECCCCCC
SFTLHNEYVRDLGEGMEPTIPVNYYPDDNPDITPKATWRSHGHLLFSNWLNYCVYQQTPY
CEEECHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCC
DLEHFSEQNFTRDE
CHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA