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The map label for this gene is fhs

Identifier: 59712400

GI number: 59712400

Start: 2024546

End: 2026294

Strand: Direct

Name: fhs

Synonym: VF_1793

Alternate gene names: 59712400

Gene position: 2024546-2026294 (Clockwise)

Preceding gene: 59712397

Following gene: 59712401

Centisome position: 69.87

GC content: 40.65

Gene sequence:

>1749_bases
ATGAAAAGCGATATTGAAATCTGCCAAACTGCGACACTTACACGAATGAAAACGATTGCGTCAAACTTAGGACTGCATGA
TGATGACATTACTCCGCAAGGTCCATTTAAGGCAAAAGTAAATATCGACGCCTTAAAACGATTAAAATCAGAACCAAATG
GTAAATTAATTTTAGTCAGCGCCATCACTCCAACACCACTTGGTGAAGGTAAAACGGTAACCACTATTGGCCTTGCTCAA
GGGCTAGCTAAATTAGGTGAATCCGTCAGTGCTTGTATTCGACAGCCATCAATGGGGCCGGTTTTTGGTGTAAAAGGAGG
TGCCGCTGGCGGTGGTTATAGCCAAGTAGCTCCAATGGAAGAGTTAAACCTACACTTAACTGGTGACATTCATGCCATCA
CCGCAGCCCATAACCTAGCTTCTGCTGCCATTGATGCTCGTATCTATCATGAACAGCGTTTAGGTTATGATGTTTTCTCA
GAAAAGAATGAGTTACCCGCTTTGCGTATTGACCCTCAACACGTGGTCTGGAAACGTGTAATGGATCACAACGATCGTGC
TCTTCGCATGGTAACCATTGGCAAAAATGAAGACGGCAAAACCATTAATGGCTATGAGCGTGAAGATGGGTTTGATATTA
CTGCAGCTTCAGAATTAATGGCTATCTTAGCACTTGCAACCGATTTACAAGACTTACGCCAACGAATTGGTCGTATTGTT
GTTGCTTATAATTTAGATGGTGAACCAGTAACGACTGAAGATTTACAAGTCGCTGGTGCAATGACGGTAACCATGAAGTT
TGCGATTAATCCAACATTGATGCAGACATTGGAAGGTGTACCTACCTTTGTTCACTCTGGACCATTTGCAAATATTGCCC
ACGGTAACTCATCAATCATTGCTGATAACATCGCTTTAAAATTAACGGATTATACCGTTACCGAAGGTGGCTTTGGTTCA
GATATGGGATTCGAAAAAGCCTGTAATATCAAAGCACCGTTATCAGAAAAATCACCAGATTGTGCGGTTCTAGTCGCAAC
ATTACGTGGTATTAAAGCCAATTCAGGCCTATTCCCTCTATCACCAGGCCAATCGCTACCTAAAGAATTATTTGCTCCAA
ATAAAGAAGCATTAGATGCGGGTCTTGATAACTTATTATGGCACATCAATAACTGTGCTAAATACGGTTTGCCTGTCGTT
GTCGCTATTAACCGATTCCCGGAAGACACTCAAGAAGAACTAGATTCATTATTAAATTGGGTTTCTAATTTAGACATGAA
TGTCGATGTAGCAATTAGCGAAGCGTTTGTTAAAGGCGGGAACGGCACATTAGAGTTAGCTGAAAAAGTAATTAAAGCGT
GTCAACAAGAGACACAATTTACTCCTTTATATACTTCTGAGATGAGCCTATTCGATAAACTTAATGCTGTAGCAATAAAA
GGTTATGGCGCTGAACGAATTGAATTATCAGAAAAAGCCCAACAACAATTAGCGACATTTGAAAAATTAGGTTACCAATC
ATTATCTGTCTGTATGGCAAAAACACCTGCTTCTATTTCTACAGATGGAAATATCAAAGGTGCGCCAACGGATTTTATTG
TGCCTATCAGAGAATTAAAACTCTGTGCAGGTGCTGGCTTTATCTATGCATTATGCGGAAATGTAATGACAATGCCAGGG
TTACCAGAAAAGCCAGCATTCATGAATTTGGACATTGATGGCGATGGTAACATCGTTGGATTAAGCTAA

Upstream 100 bases:

>100_bases
TATTTTTATGGAATAGATTCTGTATCACCTCAATTATGTGGTATAAAAAGCACGCTTTCTTTTCTGATGTTTTAACTACT
TCCTATAGGTTCCCGTTATT

Downstream 100 bases:

>100_bases
GATCACATAACTTAATGTAGATCATGTTCTATGTGTTACATTTACTGTTAATCTAGCTTCAACTTTTTATACAATTTTAA
TTATAATTTTTGAGGTTATC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 582; Mature: 582

Protein sequence:

>582_residues
MKSDIEICQTATLTRMKTIASNLGLHDDDITPQGPFKAKVNIDALKRLKSEPNGKLILVSAITPTPLGEGKTVTTIGLAQ
GLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYDVFS
EKNELPALRIDPQHVVWKRVMDHNDRALRMVTIGKNEDGKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
VAYNLDGEPVTTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVTEGGFGS
DMGFEKACNIKAPLSEKSPDCAVLVATLRGIKANSGLFPLSPGQSLPKELFAPNKEALDAGLDNLLWHINNCAKYGLPVV
VAINRFPEDTQEELDSLLNWVSNLDMNVDVAISEAFVKGGNGTLELAEKVIKACQQETQFTPLYTSEMSLFDKLNAVAIK
GYGAERIELSEKAQQQLATFEKLGYQSLSVCMAKTPASISTDGNIKGAPTDFIVPIRELKLCAGAGFIYALCGNVMTMPG
LPEKPAFMNLDIDGDGNIVGLS

Sequences:

>Translated_582_residues
MKSDIEICQTATLTRMKTIASNLGLHDDDITPQGPFKAKVNIDALKRLKSEPNGKLILVSAITPTPLGEGKTVTTIGLAQ
GLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYDVFS
EKNELPALRIDPQHVVWKRVMDHNDRALRMVTIGKNEDGKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
VAYNLDGEPVTTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVTEGGFGS
DMGFEKACNIKAPLSEKSPDCAVLVATLRGIKANSGLFPLSPGQSLPKELFAPNKEALDAGLDNLLWHINNCAKYGLPVV
VAINRFPEDTQEELDSLLNWVSNLDMNVDVAISEAFVKGGNGTLELAEKVIKACQQETQFTPLYTSEMSLFDKLNAVAIK
GYGAERIELSEKAQQQLATFEKLGYQSLSVCMAKTPASISTDGNIKGAPTDFIVPIRELKLCAGAGFIYALCGNVMTMPG
LPEKPAFMNLDIDGDGNIVGLS
>Mature_582_residues
MKSDIEICQTATLTRMKTIASNLGLHDDDITPQGPFKAKVNIDALKRLKSEPNGKLILVSAITPTPLGEGKTVTTIGLAQ
GLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYDVFS
EKNELPALRIDPQHVVWKRVMDHNDRALRMVTIGKNEDGKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
VAYNLDGEPVTTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVTEGGFGS
DMGFEKACNIKAPLSEKSPDCAVLVATLRGIKANSGLFPLSPGQSLPKELFAPNKEALDAGLDNLLWHINNCAKYGLPVV
VAINRFPEDTQEELDSLLNWVSNLDMNVDVAISEAFVKGGNGTLELAEKVIKACQQETQFTPLYTSEMSLFDKLNAVAIK
GYGAERIELSEKAQQQLATFEKLGYQSLSVCMAKTPASISTDGNIKGAPTDFIVPIRELKLCAGAGFIYALCGNVMTMPG
LPEKPAFMNLDIDGDGNIVGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=612, Percent_Identity=48.202614379085, Blast_Score=514, Evalue=1e-145,
Organism=Homo sapiens, GI36796743, Length=612, Percent_Identity=46.7320261437908, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=41.8604651162791, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=616, Percent_Identity=46.1038961038961, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17568739, Length=616, Percent_Identity=46.1038961038961, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=43.4439178515008, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321643, Length=629, Percent_Identity=43.879173290938, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI62472483, Length=622, Percent_Identity=43.4083601286174, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45551871, Length=622, Percent_Identity=43.4083601286174, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24645718, Length=622, Percent_Identity=43.4083601286174, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137370, Length=622, Percent_Identity=43.4083601286174, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_VIBF1 (Q5E3V8)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205176.1
- ProteinModelPortal:   Q5E3V8
- SMR:   Q5E3V8
- STRING:   Q5E3V8
- GeneID:   3277682
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1793
- NMPDR:   fig|312309.3.peg.1793
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   AIKPNIM
- PhylomeDB:   Q5E3V8
- ProtClustDB:   PRK13506
- BioCyc:   VFIS312309:VF1793-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 62388; Mature: 62388

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2; PS00173 XYLOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEICQTATLTRMKTIASNLGLHDDDITPQGPFKAKVNIDALKRLKSEPNGKLILVS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCEEEEE
AITPTPLGEGKTVTTIGLAQGLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPME
ECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHH
ELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYDVFSEKNELPALRIDPQHVVWKRV
HCCEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEECHHHHHHHHH
MDHNDRALRMVTIGKNEDGKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCEEE
VAYNLDGEPVTTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSII
EEEECCCCCCCHHHHEEEEEEEEEEEEECCHHHHHHHCCCCHHHHCCCCCEECCCCCCEE
ADNIALKLTDYTVTEGGFGSDMGFEKACNIKAPLSEKSPDCAVLVATLRGIKANSGLFPL
ECCEEEEEEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCC
SPGQSLPKELFAPNKEALDAGLDNLLWHINNCAKYGLPVVVAINRFPEDTQEELDSLLNW
CCCCCCCHHHHCCCHHHHHHCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHH
VSNLDMNVDVAISEAFVKGGNGTLELAEKVIKACQQETQFTPLYTSEMSLFDKLNAVAIK
HHCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCEEEEE
GYGAERIELSEKAQQQLATFEKLGYQSLSVCMAKTPASISTDGNIKGAPTDFIVPIRELK
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCHHEEEHHHHH
LCAGAGFIYALCGNVMTMPGLPEKPAFMNLDIDGDGNIVGLS
HHHCCCHHHHHHCCCEECCCCCCCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MKSDIEICQTATLTRMKTIASNLGLHDDDITPQGPFKAKVNIDALKRLKSEPNGKLILVS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCEEEEE
AITPTPLGEGKTVTTIGLAQGLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPME
ECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHH
ELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYDVFSEKNELPALRIDPQHVVWKRV
HCCEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEECHHHHHHHHH
MDHNDRALRMVTIGKNEDGKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCEEE
VAYNLDGEPVTTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSII
EEEECCCCCCCHHHHEEEEEEEEEEEEECCHHHHHHHCCCCHHHHCCCCCEECCCCCCEE
ADNIALKLTDYTVTEGGFGSDMGFEKACNIKAPLSEKSPDCAVLVATLRGIKANSGLFPL
ECCEEEEEEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCC
SPGQSLPKELFAPNKEALDAGLDNLLWHINNCAKYGLPVVVAINRFPEDTQEELDSLLNW
CCCCCCCHHHHCCCHHHHHHCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHH
VSNLDMNVDVAISEAFVKGGNGTLELAEKVIKACQQETQFTPLYTSEMSLFDKLNAVAIK
HHCCCCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCEEEEE
GYGAERIELSEKAQQQLATFEKLGYQSLSVCMAKTPASISTDGNIKGAPTDFIVPIRELK
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCHHEEEHHHHH
LCAGAGFIYALCGNVMTMPGLPEKPAFMNLDIDGDGNIVGLS
HHHCCCHHHHHHCCCEECCCCCCCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA