Click here to switch to the map view.

The map label for this gene is tcpI [H]

Identifier: 59712385

GI number: 59712385

Start: 2006633

End: 2008252

Strand: Direct

Name: tcpI [H]

Synonym: VF_1778

Alternate gene names: 59712385

Gene position: 2006633-2008252 (Clockwise)

Preceding gene: 172087727

Following gene: 59712390

Centisome position: 69.25

GC content: 33.46

Gene sequence:

>1620_bases
ATGTTTACTTTTCTAAAAAACGTTAAATTAAAAACACAATTACTAGGTTTAAGTTGGATCACTATTAGCTTTTTCTTTTT
AGTCATTTATATCTCATTTAAATATTTTGAAACTGCACAAAAAGAATCAAGTCTTCAAATATCAAATGCAGTAAATACAA
TCAATTTTGTGAATGACCAAGAAGTAACTCAACTGTGGGTTATACGTGTTCATTATTTTCGTTCACTTCAAGATAATAAA
TACCGTCAAACCTATACAAACGCATTAAATACTTGGTATGCCGACGTTAACAAATCATTTAAAGATGACGGTCAACAATC
AACTAAAGAACGAAAAATGGCGTTTGATGCTTACTATCAACACATGACACAAACAGAAACCGTACTAGACAATTACGCTA
ATGGCTTAATATCAAAAAACGAACTTAGACAATGGCAAGACAAAGCAAGTATGTTAGGCATGGATGTGGTCGATAAATTA
AATTTATTTACTACTGAGCTTTCTAATCGTGTTGATGATTCGATATCAAATTCTGAAGAAAAGTTTTCTTCCTTAATTAC
CATGTTCAGTATGATTAGTTTTCTTTTCTCTGTATTAATGCTTGCTATTTCATTTGTATTATCAAACTCAATTGTTAATC
CAATTATTTCTATAAAAGATGCAATGCTGAAAATTGCAGAGGGTGATTTATCATCAAAGCAACCAGAAGATAATGGTTCA
AATGAACTCGCTCAATTAACTTATAGTATGAATCAAACCGTTGATAAATTAGCTACCATAGCTCAAGGCTCCCATTCTAT
TGCAGAAAATGTATCTTCAGCTTCACTAGCATTAACAAACGTGATGGAAGAATCAACAGTCAATGTCCAAATTGAATTAG
AGCAAATTGAGCAAGTTGCGACAGCCGTAAATGAATTATCTCAAACCGCAACAGAAGTTAGCCTTAATGCTTCTAATGCA
GAAAAAGCAACCGTCAATGCAAATAATAGCATTTCAGAAGGTTACGATGCATTAGAGCGTTCAAAACACATTGCTGAAAA
AATTAATGATTCGGTAAAAGAATCAGCAACGATAGTAAATCAATTGCGTGAATATTCTTCTGATATTGGTTCAGTCGTTG
AAGTGATTAATAACATTTCTGAACAAACGAATTTATTAGCACTTAATGCTGCTATTGAAGCAGCGAGAGCTGGTGAACAA
GGAAGAGGATTTGCGGTTGTTGCAGATGAAGTTCGAGCATTAGCGGCAAAAACTCAACATTCAACGGTTAGTATTCAAGA
GATTATTTCCAAATTACAAGAACAAGCTGAGAAGGCAGATCAGCATATGACTGAAAACTCACATTTAGTCGGAGAATCTC
AATTCATCGCAGAAGAGGTGAATACGACGTTCAATCAAATCTCGAACGCTGTACTTCATATTTCAGAAATGAATACACTT
GTTGCAACAGCTTCTGAAGAGCAGGCGTGTGTAACTCAAGAAATAACAAAAAATATCATGTTAACTTCAGAAATGGTTAA
TCAAAATGCTGAGAGCATCAAAAAGAATGCTCAGGAAAGTGAAGTATTAGCTCAACAGTCTGAAGAACAAAAACACCTTC
TATCTTTCTTTAAAATCTAA

Upstream 100 bases:

>100_bases
CTTTTAGTGCAAACACTCTAAATAATTAAAGGGGTAATATTCCCTTTTCATTTTTTATAAATACAATCCGCATCTCATTT
TTCAGCCTCTTACATTTTAT

Downstream 100 bases:

>100_bases
TACATACTCGATACAAAAGTATAAGCTATTTCGTATTGAACATTTTTTTACCGCTTTTATCTTGATCAGACCAAAAATTA
ATATTGAATTGAGCATCGTC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: TCP pilus biosynthesis protein tcpI [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MFTFLKNVKLKTQLLGLSWITISFFFLVIYISFKYFETAQKESSLQISNAVNTINFVNDQEVTQLWVIRVHYFRSLQDNK
YRQTYTNALNTWYADVNKSFKDDGQQSTKERKMAFDAYYQHMTQTETVLDNYANGLISKNELRQWQDKASMLGMDVVDKL
NLFTTELSNRVDDSISNSEEKFSSLITMFSMISFLFSVLMLAISFVLSNSIVNPIISIKDAMLKIAEGDLSSKQPEDNGS
NELAQLTYSMNQTVDKLATIAQGSHSIAENVSSASLALTNVMEESTVNVQIELEQIEQVATAVNELSQTATEVSLNASNA
EKATVNANNSISEGYDALERSKHIAEKINDSVKESATIVNQLREYSSDIGSVVEVINNISEQTNLLALNAAIEAARAGEQ
GRGFAVVADEVRALAAKTQHSTVSIQEIISKLQEQAEKADQHMTENSHLVGESQFIAEEVNTTFNQISNAVLHISEMNTL
VATASEEQACVTQEITKNIMLTSEMVNQNAESIKKNAQESEVLAQQSEEQKHLLSFFKI

Sequences:

>Translated_539_residues
MFTFLKNVKLKTQLLGLSWITISFFFLVIYISFKYFETAQKESSLQISNAVNTINFVNDQEVTQLWVIRVHYFRSLQDNK
YRQTYTNALNTWYADVNKSFKDDGQQSTKERKMAFDAYYQHMTQTETVLDNYANGLISKNELRQWQDKASMLGMDVVDKL
NLFTTELSNRVDDSISNSEEKFSSLITMFSMISFLFSVLMLAISFVLSNSIVNPIISIKDAMLKIAEGDLSSKQPEDNGS
NELAQLTYSMNQTVDKLATIAQGSHSIAENVSSASLALTNVMEESTVNVQIELEQIEQVATAVNELSQTATEVSLNASNA
EKATVNANNSISEGYDALERSKHIAEKINDSVKESATIVNQLREYSSDIGSVVEVINNISEQTNLLALNAAIEAARAGEQ
GRGFAVVADEVRALAAKTQHSTVSIQEIISKLQEQAEKADQHMTENSHLVGESQFIAEEVNTTFNQISNAVLHISEMNTL
VATASEEQACVTQEITKNIMLTSEMVNQNAESIKKNAQESEVLAQQSEEQKHLLSFFKI
>Mature_539_residues
MFTFLKNVKLKTQLLGLSWITISFFFLVIYISFKYFETAQKESSLQISNAVNTINFVNDQEVTQLWVIRVHYFRSLQDNK
YRQTYTNALNTWYADVNKSFKDDGQQSTKERKMAFDAYYQHMTQTETVLDNYANGLISKNELRQWQDKASMLGMDVVDKL
NLFTTELSNRVDDSISNSEEKFSSLITMFSMISFLFSVLMLAISFVLSNSIVNPIISIKDAMLKIAEGDLSSKQPEDNGS
NELAQLTYSMNQTVDKLATIAQGSHSIAENVSSASLALTNVMEESTVNVQIELEQIEQVATAVNELSQTATEVSLNASNA
EKATVNANNSISEGYDALERSKHIAEKINDSVKESATIVNQLREYSSDIGSVVEVINNISEQTNLLALNAAIEAARAGEQ
GRGFAVVADEVRALAAKTQHSTVSIQEIISKLQEQAEKADQHMTENSHLVGESQFIAEEVNTTFNQISNAVLHISEMNTL
VATASEEQACVTQEITKNIMLTSEMVNQNAESIKKNAQESEVLAQQSEEQKHLLSFFKI

Specific function: May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (tcpA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=368, Percent_Identity=29.0760869565217, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI2367378, Length=415, Percent_Identity=27.4698795180723, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1789453, Length=345, Percent_Identity=26.0869565217391, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788195, Length=312, Percent_Identity=28.525641025641, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788194, Length=251, Percent_Identity=29.8804780876494, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004089 [H]

Pfam domain/function: PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 60142; Mature: 60142

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8005659 [H]