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The map label for this gene is rnd [H]

Identifier: 59712314

GI number: 59712314

Start: 1922957

End: 1924078

Strand: Reverse

Name: rnd [H]

Synonym: VF_1707

Alternate gene names: 59712314

Gene position: 1924078-1922957 (Counterclockwise)

Preceding gene: 59712315

Following gene: 59712310

Centisome position: 66.4

GC content: 38.41

Gene sequence:

>1122_bases
GTGGAATTTGAAATCGTTACCCAGAGTCAGCGTTTAGCTGAGATCTGTCAGCAGGCAAGCACGAAACCATTTTTAATGTT
GGATACTGAGTTTGTAAGAACGCGAACGTTATATGCACGTTTAGGTTTAATTCAAATGTTTGATGGTGAGACATTAGCGC
TTGTTGATCCGGTTGAGATTGATGATTTAACGCCTCTTTGGGATTTATTGAAAAACGAATCAGTGACAAAAGTACTTCAT
GCATGTGGTGAAGATTTAGAGGTATTCCAACATTACGCTGGTTGTATGCCAACACCTATGATTGATACACAAATCATGGC
GGCATTTTTAGGTTATGGACTTTCTACGGGATTCGCTAAGCTGGTTTCTGACTACCTAGGTATTGAATTAGATAAAGGCG
AAGCAAGAACGGATTGGATGGCACGTCCATTATCCGATAAGCAACTTCACTATGCAGCGGCAGATGTGCATTATTTATTG
CCATTATTTGAAAAACTTCAAGCTGAGTTATCTCAAACTCAATGGGAAGATGCGGCTTATCAAGAGTCAGCACTTGCAGT
AAAAAAACGTGAAAAGCAACCGGATGCAGAAAAGGCTTATCTAGATATTAAAAATGCATGGCAACTCAATCCTAAGCAGT
TAGCTATTTTAAAAATGGCAGCAAAGTGGCGTTTAGAAGAAGCGAGAAAGCGTGATTTAGCGGTTAACTTTGTTGTAAAA
GAGCTGAGTCTTTGGAAACTGGCTCGATTTGGGCTTCGTAGTAAAGATCAAATGCTTAAAGAAGAATTTGATCCAAGAGA
AGTTCAACGTCATGGTGGTAAATTATTACGTTTTACTTACTTAGCCGATGATTTGAATCCCAATGAATACCCTGAACCAG
TAACACGTTTAATGGATTACCCAGGCTATAAGCAAATCTTTAAATTACTAAAAGATGAAGTGAAAATAGCTTCGGATAAA
TCGGGTTTAATGCCTGAGTTTTTAGCATCGAAAAAACAGCTAAATCAATTATTGTCTTGGAAATGGAAAAAGAACGCAGC
ACCAGAGTTAAAACCTGATGTATTAAAAGGGTGGCGTGGTGAATTATTAGAAGCGCGCTTTATGTCTGTGATTGAAAAGT
AG

Upstream 100 bases:

>100_bases
GCCAGCCTAATCGCTGGCATTATTTTTATTTATAGAGACAAGATAGCTTAGTTTTACTGAAATTAAGCTATCTTGCCTTG
GCATCTATTAAGGAAATACT

Downstream 100 bases:

>100_bases
CAGTTCAAAAATAAAAAAAGGTGACTCATGAGTCACCTTTTTAATGCACGTTTAAAACTGTATTGTCAGTTTAATGATCG
TCTTCGTCAGGAAGAGTAAC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MEFEIVTQSQRLAEICQQASTKPFLMLDTEFVRTRTLYARLGLIQMFDGETLALVDPVEIDDLTPLWDLLKNESVTKVLH
ACGEDLEVFQHYAGCMPTPMIDTQIMAAFLGYGLSTGFAKLVSDYLGIELDKGEARTDWMARPLSDKQLHYAAADVHYLL
PLFEKLQAELSQTQWEDAAYQESALAVKKREKQPDAEKAYLDIKNAWQLNPKQLAILKMAAKWRLEEARKRDLAVNFVVK
ELSLWKLARFGLRSKDQMLKEEFDPREVQRHGGKLLRFTYLADDLNPNEYPEPVTRLMDYPGYKQIFKLLKDEVKIASDK
SGLMPEFLASKKQLNQLLSWKWKKNAAPELKPDVLKGWRGELLEARFMSVIEK

Sequences:

>Translated_373_residues
MEFEIVTQSQRLAEICQQASTKPFLMLDTEFVRTRTLYARLGLIQMFDGETLALVDPVEIDDLTPLWDLLKNESVTKVLH
ACGEDLEVFQHYAGCMPTPMIDTQIMAAFLGYGLSTGFAKLVSDYLGIELDKGEARTDWMARPLSDKQLHYAAADVHYLL
PLFEKLQAELSQTQWEDAAYQESALAVKKREKQPDAEKAYLDIKNAWQLNPKQLAILKMAAKWRLEEARKRDLAVNFVVK
ELSLWKLARFGLRSKDQMLKEEFDPREVQRHGGKLLRFTYLADDLNPNEYPEPVTRLMDYPGYKQIFKLLKDEVKIASDK
SGLMPEFLASKKQLNQLLSWKWKKNAAPELKPDVLKGWRGELLEARFMSVIEK
>Mature_373_residues
MEFEIVTQSQRLAEICQQASTKPFLMLDTEFVRTRTLYARLGLIQMFDGETLALVDPVEIDDLTPLWDLLKNESVTKVLH
ACGEDLEVFQHYAGCMPTPMIDTQIMAAFLGYGLSTGFAKLVSDYLGIELDKGEARTDWMARPLSDKQLHYAAADVHYLL
PLFEKLQAELSQTQWEDAAYQESALAVKKREKQPDAEKAYLDIKNAWQLNPKQLAILKMAAKWRLEEARKRDLAVNFVVK
ELSLWKLARFGLRSKDQMLKEEFDPREVQRHGGKLLRFTYLADDLNPNEYPEPVTRLMDYPGYKQIFKLLKDEVKIASDK
SGLMPEFLASKKQLNQLLSWKWKKNAAPELKPDVLKGWRGELLEARFMSVIEK

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=235, Percent_Identity=27.2340425531915, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI50301240, Length=235, Percent_Identity=27.2340425531915, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788105, Length=373, Percent_Identity=46.112600536193, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17531757, Length=249, Percent_Identity=27.710843373494, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI161078302, Length=255, Percent_Identity=25.8823529411765, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43010; Mature: 43010

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEIVTQSQRLAEICQQASTKPFLMLDTEFVRTRTLYARLGLIQMFDGETLALVDPVEI
CCCEEECCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHEEECCCEEEEECCCCC
DDLTPLWDLLKNESVTKVLHACGEDLEVFQHYAGCMPTPMIDTQIMAAFLGYGLSTGFAK
CCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
LVSDYLGIELDKGEARTDWMARPLSDKQLHYAAADVHYLLPLFEKLQAELSQTQWEDAAY
HHHHHHCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QESALAVKKREKQPDAEKAYLDIKNAWQLNPKQLAILKMAAKWRLEEARKRDLAVNFVVK
HHHHHHHHHHCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELSLWKLARFGLRSKDQMLKEEFDPREVQRHGGKLLRFTYLADDLNPNEYPEPVTRLMDY
HHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHCC
PGYKQIFKLLKDEVKIASDKSGLMPEFLASKKQLNQLLSWKWKKNAAPELKPDVLKGWRG
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ELLEARFMSVIEK
HHHHHHHHHHHCC
>Mature Secondary Structure
MEFEIVTQSQRLAEICQQASTKPFLMLDTEFVRTRTLYARLGLIQMFDGETLALVDPVEI
CCCEEECCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHEEECCCEEEEECCCCC
DDLTPLWDLLKNESVTKVLHACGEDLEVFQHYAGCMPTPMIDTQIMAAFLGYGLSTGFAK
CCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
LVSDYLGIELDKGEARTDWMARPLSDKQLHYAAADVHYLLPLFEKLQAELSQTQWEDAAY
HHHHHHCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QESALAVKKREKQPDAEKAYLDIKNAWQLNPKQLAILKMAAKWRLEEARKRDLAVNFVVK
HHHHHHHHHHCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELSLWKLARFGLRSKDQMLKEEFDPREVQRHGGKLLRFTYLADDLNPNEYPEPVTRLMDY
HHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHCC
PGYKQIFKLLKDEVKIASDKSGLMPEFLASKKQLNQLLSWKWKKNAAPELKPDVLKGWRG
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ELLEARFMSVIEK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]