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The map label for this gene is hisQ [H]

Identifier: 59712193

GI number: 59712193

Start: 1776801

End: 1777541

Strand: Reverse

Name: hisQ [H]

Synonym: VF_1586

Alternate gene names: 59712193

Gene position: 1777541-1776801 (Counterclockwise)

Preceding gene: 59712194

Following gene: 59712192

Centisome position: 61.35

GC content: 39.41

Gene sequence:

>741_bases
ATGTTAGATTTACAAGGATATGAATCCTCCATTTTAGATGGAGCATTGGTCACGCTGCAGGTTGCGCTCCTATCTCTTCT
CTTAGCCGTATTTCTTGGCTTACTTGGTGCTTTGGCGAAAATGGCTCCATATCGTTGGGCTCGATCTATTGCCACACTTT
ATACAACTATTGTTCGAGGGATCCCTGATTTAGTATTAATGATGCTACTGTTTTTTGGCGGACAAATGCTATTAAACAAT
GGGCTGTATGCGAGTAATGAATGGATAAATGAGTGGATGACAAACTCAAACCCAGATCATGAATGGATTTCTTATCTTCC
TGATTATATAGAAATTAGTCCTTTTATCGCAGGTGTCCTAACCATTGGTTTTATTTTTGGCGCGTATATGGCTGAGACAT
TTCGTGGTGCAATCATGGCGGTAGATCGTGGTGAAATGGAAGCAGCAAAAGCCTATGGTATGAGTGGCATGATGGCATTT
CGTCGTATTTTGTTTCCGCAAATGATCCGTCATGCGTTACCTGGTTTTGGTAACAATTGGTTAGTTCTACTTAAAACCAC
CGCTTTGGTTTCGATTATTGGTTTAGAAGATATGGTTCGTGTTAGCTCAATGGCTGCTGGAACAACTAAGATGCCATTTA
CTTTTTATATGACAGTTGCTTGTATTTTCTTATTTTTCACAGCAGTTTCAACTGGTGCGTTAAAACTTATTGAACGTAAA
TTTAGTATTCACATGAGGTAG

Upstream 100 bases:

>100_bases
GGTGGAATATACCTCTTTCATTCTAATAGTTATAACAACGTCAATGAAGCGTTCTTGATATTTATTGGCGTTGTTATTAA
AGCGAAAGCTTGGAAGTAGT

Downstream 100 bases:

>100_bases
ATATGGATTTTTCAATTATCATTGAGAGCTTTCCTGTTTATCTTGAAGGCTTATGGACAACGGTGTGGTTAGTAGCGGTA
TCTTTGGTGATTGGTTTGTG

Product: histidine/lysine/arginine/ornithine transporter subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLDLQGYESSILDGALVTLQVALLSLLLAVFLGLLGALAKMAPYRWARSIATLYTTIVRGIPDLVLMMLLFFGGQMLLNN
GLYASNEWINEWMTNSNPDHEWISYLPDYIEISPFIAGVLTIGFIFGAYMAETFRGAIMAVDRGEMEAAKAYGMSGMMAF
RRILFPQMIRHALPGFGNNWLVLLKTTALVSIIGLEDMVRVSSMAAGTTKMPFTFYMTVACIFLFFTAVSTGALKLIERK
FSIHMR

Sequences:

>Translated_246_residues
MLDLQGYESSILDGALVTLQVALLSLLLAVFLGLLGALAKMAPYRWARSIATLYTTIVRGIPDLVLMMLLFFGGQMLLNN
GLYASNEWINEWMTNSNPDHEWISYLPDYIEISPFIAGVLTIGFIFGAYMAETFRGAIMAVDRGEMEAAKAYGMSGMMAF
RRILFPQMIRHALPGFGNNWLVLLKTTALVSIIGLEDMVRVSSMAAGTTKMPFTFYMTVACIFLFFTAVSTGALKLIERK
FSIHMR
>Mature_246_residues
MLDLQGYESSILDGALVTLQVALLSLLLAVFLGLLGALAKMAPYRWARSIATLYTTIVRGIPDLVLMMLLFFGGQMLLNN
GLYASNEWINEWMTNSNPDHEWISYLPDYIEISPFIAGVLTIGFIFGAYMAETFRGAIMAVDRGEMEAAKAYGMSGMMAF
RRILFPQMIRHALPGFGNNWLVLLKTTALVSIIGLEDMVRVSSMAAGTTKMPFTFYMTVACIFLFFTAVSTGALKLIERK
FSIHMR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=243, Percent_Identity=46.5020576131687, Blast_Score=217, Evalue=6e-58,
Organism=Escherichia coli, GI1787087, Length=229, Percent_Identity=35.3711790393013, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787030, Length=233, Percent_Identity=27.4678111587983, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788226, Length=237, Percent_Identity=26.1603375527426, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788645, Length=233, Percent_Identity=27.0386266094421, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1786874, Length=235, Percent_Identity=23.8297872340426, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27375; Mature: 27375

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.3 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
7.3 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLQGYESSILDGALVTLQVALLSLLLAVFLGLLGALAKMAPYRWARSIATLYTTIVRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPDLVLMMLLFFGGQMLLNNGLYASNEWINEWMTNSNPDHEWISYLPDYIEISPFIAGVL
CHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHH
TIGFIFGAYMAETFRGAIMAVDRGEMEAAKAYGMSGMMAFRRILFPQMIRHALPGFGNNW
HHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCC
LVLLKTTALVSIIGLEDMVRVSSMAAGTTKMPFTFYMTVACIFLFFTAVSTGALKLIERK
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSIHMR
HHHCCC
>Mature Secondary Structure
MLDLQGYESSILDGALVTLQVALLSLLLAVFLGLLGALAKMAPYRWARSIATLYTTIVRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPDLVLMMLLFFGGQMLLNNGLYASNEWINEWMTNSNPDHEWISYLPDYIEISPFIAGVL
CHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHH
TIGFIFGAYMAETFRGAIMAVDRGEMEAAKAYGMSGMMAFRRILFPQMIRHALPGFGNNW
HHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCC
LVLLKTTALVSIIGLEDMVRVSSMAAGTTKMPFTFYMTVACIFLFFTAVSTGALKLIERK
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSIHMR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]